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HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18297-18302

2014

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Mitochondrial electron transport is the cellular target of the oncology drug elesclomol

PloS one, 2012-01, Vol.7 (1), p.e29798-e29798

2012

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Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.475-484

2012

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Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy

Cancer immunology research, 2015-06, Vol.3 (6), p.583-589

2015

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Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer

Cancer discovery, 2013-04, Vol.3 (4), p.430-443

2013

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Reconstruction of human mammary tissues in a mouse model

Nature protocols, 2006-06, Vol.1 (1), p.206-214

2006

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Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer

Cell reports (Cambridge), 2016-07, Vol.16 (3), p.657-671

2016

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The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer

Investigational new drugs, 2014-08, Vol.32 (4), p.577-586

2014

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Ganetespib limits ciliation and cystogenesis in autosomal‐dominant polycystic kidney disease (ADPKD)

The FASEB journal, 2018-05, Vol.32 (5), p.2735-2746

2018

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FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism

Molecular cancer research, 2014-07, Vol.12 (7), p.1042-1054

2014

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Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors

Clinical cancer research, 2018-12, Vol.24 (24), p.6396-6407

2018

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Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling

PloS one, 2011-04, Vol.6 (4), p.e18552

2011

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mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis

Molecular cancer research, 2014-05, Vol.12 (5), p.703-713

2014

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Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (31), p.12786-12791

2013

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Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression

International journal of oncology, 2013-01, Vol.42 (1), p.35-43

2013

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Ganetespib and HSP90: Translating Preclinical Hypotheses into Clinical Promise

Cancer research (Chicago, Ill.), 2014-03, Vol.74 (5), p.1294-1300

2014

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Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice

PloS one, 2014-12, Vol.9 (12), p.e114403

2014

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The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

Cancers, 2015-05, Vol.7 (2), p.876-907

2015

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Stroma: Tumor Agonist or Antagonist

Cell cycle (Georgetown, Tex.), 2005-08, Vol.4 (8), p.1022-1025

2005

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Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib

Molecular cancer therapeutics, 2014-02, Vol.13 (2), p.353-363

2014

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Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib

Molecular cancer therapeutics, 2012-12, Vol.11 (12), p.2633-2643

2012

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Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation

Clinical cancer research, 2016-12, Vol.22 (23), p.5876-5886

2016

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Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

Molecular cancer therapeutics, 2021-08, Vol.20 (8), p.1367-1377

2021

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Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Clinical cancer research, 2014-01, Vol.20 (2), p.413-424

2014

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Dual Roles for the Phosphatase PPM1D in Regulating Progesterone Receptor Function

The Journal of biological chemistry, 2006-03, Vol.281 (11), p.7089-7101

2006

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HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol

Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy

Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy

Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer

Reconstruction of human mammary tissues in a mouse model

Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer

The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer

Ganetespib limits ciliation and cystogenesis in autosomal‐dominant polycystic kidney disease (ADPKD)

FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism

Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors

Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling

mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis

Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease

Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression

Ganetespib and HSP90: Translating Preclinical Hypotheses into Clinical Promise

Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

Stroma: Tumor Agonist or Antagonist

Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib

Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib

Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation

Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Dual Roles for the Phosphatase PPM1D in Regulating Progesterone Receptor Function

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