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Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

Nitric oxide, 2018-08, Vol.78, p.72-80

2018

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PRO 2000 Gel Inhibits HIV and Herpes Simplex Virus Infection Following Vaginal Application: A Double-Blind Placebo-Controlled Trial

The Journal of infectious diseases, 2006-01, Vol.193 (1), p.27-35

2006

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Principal Neutralizing Domain of the Human Immunodeficiency Virus Type 1 Envelope Protein

Proceedings of the National Academy of Sciences - PNAS, 1989-09, Vol.86 (17), p.6768-6772

1989

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Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing Fabs

Structure (London), 1999-02, Vol.7 (2), p.131-142

1999

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Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread

Antimicrobial Agents and Chemotherapy, 2004-06, Vol.48 (6), p.2025-2036

2004

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Crystal Structure of the Principal Neutralization Site of HIV-1

Science (American Association for the Advancement of Science), 1994-04, Vol.264 (5155), p.82-85

1994

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Crystal Structure of a Human Immunodeficiency Virus Type 1 Neutralizing Antibody, 50.1, in Complex with Its V3 Loop Peptide Antigen

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (13), p.6325-6329

1993

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Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities

Antimicrobial Agents and Chemotherapy, 1996-01, Vol.40 (1), p.234-236

1996

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Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant

Science (American Association for the Advancement of Science), 1990-08, Vol.249 (4971), p.932-935

1990

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Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1

Science (American Association for the Advancement of Science), 1990-12, Vol.250 (4987), p.1590-1593

1990

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Predictive Power of an In Vitro System to Assess Drug Interactions of an Antimuscarinic Medication: A Comparison of In Vitro and In Vivo Drug-Drug Interaction Studies of Trospium Chloride With Digoxin

Journal of clinical pharmacology, 2006-07, Vol.46 (7), p.776-784

2006

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The Topical Microbicide PRO 2000 Protects against Genital Herpes Infection in a Mouse Model

The Journal of infectious diseases, 1999-07, Vol.180 (1), p.203-205

1999

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Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop

Virology (New York, N.Y.), 2003-10, Vol.315 (1), p.159-173

2003

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A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women

Sexually transmitted infections, 2000-04, Vol.76 (2), p.126-130

2000

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Direct measurement of in-vivo vaginal microbicide levels of PRO 2000 achieved in a human safety study

AIDS (London), 2006-04, Vol.20 (7), p.1027-1030

2006

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PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity

AIDS (London), 2007-02, Vol.21 (4), p.467-476

2007

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Major antigen-induced domain rearrangements in an antibody

Structure (London), 1993-10, Vol.1 (2), p.83-93

1993

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The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1

Antiviral research, 2009-10, Vol.84 (1), p.38-47

2009

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HPTN 035 phase II/IIb randomised safety and effectiveness study of the vaginal microbicides BufferGel and 0.5% PRO 2000 for the prevention of sexually transmitted infections in women

Sexually transmitted infections, 2014-08, Vol.90 (5), p.363-369

2014

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Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive men

Journal of acquired immune deficiency syndromes (1999), 2003-08, Vol.33 (4), p.476-483

2003

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Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120

Biochemistry (Easton), 1991-09, Vol.30 (38), p.9187-9194

1991

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Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strain

Proceedings of the National Academy of Sciences - PNAS, 1990-11, Vol.87 (21), p.8597-8601

1990

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Epitopes recognized by the neutralizing antibodies of an HIV-1-infected individual

The Journal of immunology (1950), 1990-06, Vol.144 (12), p.4641-4647

1990

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A chemically defined synthetic vaccine model for HIV-1

The Journal of immunology (1950), 1992-02, Vol.148 (3), p.914-920

1992

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ACIDFORM Inactivates Herpes Simplex Virus and Prevents Genital Herpes in a Mouse Model: Optimal Candidate for Microbicide Combinations

The Journal of infectious diseases, 2006-09, Vol.194 (6), p.795-803

2006

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Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

PRO 2000 Gel Inhibits HIV and Herpes Simplex Virus Infection Following Vaginal Application: A Double-Blind Placebo-Controlled Trial

Principal Neutralizing Domain of the Human Immunodeficiency Virus Type 1 Envelope Protein

Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing Fabs

Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread

Crystal Structure of the Principal Neutralization Site of HIV-1

Crystal Structure of a Human Immunodeficiency Virus Type 1 Neutralizing Antibody, 50.1, in Complex with Its V3 Loop Peptide Antigen

Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities

Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant

Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1

Predictive Power of an In Vitro System to Assess Drug Interactions of an Antimuscarinic Medication: A Comparison of In Vitro and In Vivo Drug-Drug Interaction Studies of Trospium Chloride With Digoxin

The Topical Microbicide PRO 2000 Protects against Genital Herpes Infection in a Mouse Model

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop

A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women

Direct measurement of in-vivo vaginal microbicide levels of PRO 2000 achieved in a human safety study

PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity

Major antigen-induced domain rearrangements in an antibody

The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1

HPTN 035 phase II/IIb randomised safety and effectiveness study of the vaginal microbicides BufferGel and 0.5% PRO 2000 for the prevention of sexually transmitted infections in women

Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive men

Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120

Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strain

Epitopes recognized by the neutralizing antibodies of an HIV-1-infected individual

A chemically defined synthetic vaccine model for HIV-1

ACIDFORM Inactivates Herpes Simplex Virus and Prevents Genital Herpes in a Mouse Model: Optimal Candidate for Microbicide Combinations

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