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Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease

Science translational medicine, 2022-02, Vol.14 (630)

2022

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Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

Scientific reports, 2021-09, Vol.11 (1), p.17977-17977, Article 17977

2021

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Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.312-319

2011

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[ 11 C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12003-12021

2021

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Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1159-1183

2015

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A versatile, non-biomimetic route to the preussomerins: syntheses of (+/-)-preussomerins F, K and L

Organic & biomolecular chemistry, 2004-09, Vol.2 (17), p.2483-2495

2004

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SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease

ACS medicinal chemistry letters, 2012-12, Vol.3 (12), p.1024-1028

2012

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Irreversible 4‑Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease

ACS medicinal chemistry letters, 2012-09, Vol.3 (9), p.731-735

2012

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Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8608-8633

2020

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Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.641-656

2023

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A Novel Route to Preussomerins via 2-Arylacetal Anions

Organic letters, 2000-06, Vol.2 (11), p.1613-1616

2000

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Concise Syntheses of γ-Oxo-β,β-difluorinated Amino Acids via Chelated [3,3]-Rearrangement of Difluoroallylic Alcohols

Journal of organic chemistry, 1998-10, Vol.63 (22), p.8049-8051

1998

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Rearrangement routes to selectively fluorinated compounds

Journal of fluorine chemistry, 1999-12, Vol.100 (1), p.147-156

1999

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Synthesis of α-hydroxy-β,β-difluoro-γ-ketoesters via [3,3]sigmatropic rearrangements

Perkin 1 : an international journal of organic and bio-organic chemistry, 2000 (19), p.3217-3226

2000

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ChemInform Abstract: Rearrangement Routes to Selectively Fluorinated Compounds

ChemInform, 2000-02, Vol.31 (8), p.no-no

2000

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ChemInform Abstract: Concise Syntheses of γ-Oxo-β,β-difluorinated Amino Acids via Chelated [3,3]-Rearrangement of Difluoroallylic Alcohols

ChemInform, 1999-03, Vol.30 (13), p.no-no

1999

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A Versatile, Non-Biomimetic Route to the Preussomerins: Syntheses of (.+-.)-Preussomerins F, K and L

ChemInform, 2005-02, Vol.36 (5), p.no-no

2005

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ChemInform Abstract: Synthesis of α-Hydroxy-β,β-difluoro-γ-ketoesters via [3,3]Sigmatropic Rearrangements

ChemInform, 2001-02, Vol.32 (7), p.no-no

2001

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ChemInform Abstract: A Novel Route to Preussomerins via 2-Arylacetal Anions

ChemInform, 2000-09, Vol.31 (37), p.no-no

2000

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Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2022-07, Vol.328 (2), p.151

2022

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Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo

Emerging infectious diseases, 2014-02, Vol.20 (2), p.232-239

2014

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Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Cell metabolism, 2011-03, Vol.13 (3), p.340-350

2011

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Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

The American journal of gastroenterology, 2012-09, Vol.107 (9), p.1315-1329

2012

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Accelerating the Evolution of Nonhuman Primate Neuroimaging

Neuron (Cambridge, Mass.), 2020-02, Vol.105 (4), p.600-603

2020

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Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase

Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease

[ 11 C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

A versatile, non-biomimetic route to the preussomerins: syntheses of (+/-)-preussomerins F, K and L

SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease

Irreversible 4‑Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates

A Novel Route to Preussomerins via 2-Arylacetal Anions

Concise Syntheses of γ-Oxo-β,β-difluorinated Amino Acids via Chelated [3,3]-Rearrangement of Difluoroallylic Alcohols

Rearrangement routes to selectively fluorinated compounds

Synthesis of α-hydroxy-β,β-difluoro-γ-ketoesters via [3,3]sigmatropic rearrangements

ChemInform Abstract: Rearrangement Routes to Selectively Fluorinated Compounds

ChemInform Abstract: Concise Syntheses of γ-Oxo-β,β-difluorinated Amino Acids via Chelated [3,3]-Rearrangement of Difluoroallylic Alcohols

A Versatile, Non-Biomimetic Route to the Preussomerins: Syntheses of (.+-.)-Preussomerins F, K and L

ChemInform Abstract: Synthesis of α-Hydroxy-β,β-difluoro-γ-ketoesters via [3,3]Sigmatropic Rearrangements

ChemInform Abstract: A Novel Route to Preussomerins via 2-Arylacetal Anions

Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial

Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

Accelerating the Evolution of Nonhuman Primate Neuroimaging

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