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Tissue factor–fVIIa inhibition: update on an unfinished quest for a novel oral antithrombotic

Drug discovery today, 2014-09, Vol.19 (9), p.1440-1444

Priestley, E. Scott

2014

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Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

Science translational medicine, 2017-01, Vol.9 (371)

2017

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Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3571-3589

2024

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Microscale purification in support of high-throughput medicinal chemistry

Chemical communications (Cambridge, England), 2021-10, Vol.57 (84), p.1137-114

2021

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Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.6225-6236

2015

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Atropisomer Control in Macrocyclic Factor VIIa Inhibitors

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.4007-4018

2016

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Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

Journal of medicinal chemistry, 2019-08, Vol.62 (16), p.7400-7416

2019

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Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (8), p.2432-2435

2013

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The Synthesis and evaluation of a novel class of ( E)-3-(1-cyclohexyl-1 H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2869-2872

2011

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Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa–Tissue Factor Complex

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7125-7137

2016

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Correction to “Atropisomer Control in Macrocyclic Factor VIIa Inhibitors”

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3752-3752

2018

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Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2799-2808

2015

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Neutral macrocyclic factor VIIa inhibitors

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (12), p.2650-2654

2017

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Synthesis and P1′ SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (20), p.5051-5057

2016

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BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies

Thrombosis and haemostasis, 2010-08, Vol.104 (2), p.261-269

2010

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Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (6), p.1604-1607

2013

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Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (10), p.2169-2173

2015

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Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1077-1081

2016

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Direct Observation of Aminoglycoside−RNA Interactions by Surface Plasmon Resonance

Journal of the American Chemical Society, 1997-04, Vol.119 (16), p.3641-3648

1997

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Nonbenzamidine acylsulfonamide tissue factor–factor VIIa inhibitors

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (18), p.5244-5248

2013

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Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors

ACS medicinal chemistry letters, 2017-01, Vol.8 (1), p.67-72

2017

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Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

ACS medicinal chemistry letters, 2014-02, Vol.5 (2), p.188-192

2014

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P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3199-3202

2002

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Tissue factor–fVIIa inhibition: update on an unfinished quest for a novel oral antithrombotic

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis

Microscale purification in support of high-throughput medicinal chemistry

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4

Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure

Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors

Atropisomer Control in Macrocyclic Factor VIIa Inhibitors

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

The Synthesis and evaluation of a novel class of ( E)-3-(1-cyclohexyl-1 H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors

Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa–Tissue Factor Complex

Correction to “Atropisomer Control in Macrocyclic Factor VIIa Inhibitors”

Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening

Neutral macrocyclic factor VIIa inhibitors

Synthesis and P1′ SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors

BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies

Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors

Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors

Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

Direct Observation of Aminoglycoside−RNA Interactions by Surface Plasmon Resonance

Nonbenzamidine acylsulfonamide tissue factor–factor VIIa inhibitors

Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors

Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease

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