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Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.8685-8711

2016

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Identification of [1,2,3]Triazolo[4,5‑d]pyrimidin-7(6H)‑ones as Novel Inhibitors of Chikungunya Virus Replication

Journal of medicinal chemistry, 2014-05, Vol.57 (10), p.4000-4008

2014

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High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

Scientific reports, 2018-03, Vol.8 (1), p.4242-17, Article 4242

2018

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Antivirals against (Re)emerging Flaviviruses: Should We Target the Virus or the Host?

ACS medicinal chemistry letters, 2022-01, Vol.13 (1), p.5-10

2022

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Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1

Antiviral research, 2017-08, Vol.144, p.216-222

2017

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Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation

International journal of molecular sciences, 2022-11, Vol.23 (22), p.13935

2022

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Novel Colchicine-Site Binders with a Cyclohexanedione Scaffold Identified through a Ligand-Based Virtual Screening Approach

Journal of medicinal chemistry, 2014-05, Vol.57 (10), p.3924-3938

2014

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Chikungunya virus drug discovery: still a long way to go?

Expert opinion on drug discovery, 2019-09, Vol.14 (9), p.855-866

2019

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Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T‑cell Acute Lymphoblastic Leukemia

ACS medicinal chemistry letters, 2019-04, Vol.10 (4), p.639-643

2019

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Antivascular and antitumor properties of the tubulin-binding chalcone TUB091

Oncotarget, 2017-02, Vol.8 (9), p.14325-14342

2017

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Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity

Molecules (Basel, Switzerland), 2019-11, Vol.24 (23), p.4236

2019

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Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

Pharmaceuticals (Basel, Switzerland), 2022-07, Vol.15 (7), p.835

2022

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Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity

European journal of medicinal chemistry, 2018-03, Vol.148, p.337-348

2018

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Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease

ACS chemical neuroscience, 2022-01, Vol.13 (2), p.275-287

2022

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Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop

European journal of medicinal chemistry, 2019-06, Vol.171, p.195-208

2019

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Inhibition of the Replication of Different Strains of Chikungunya Virus by 3‑Aryl-[1,2,3]triazolo[4,5‑d]pyrimidin-7(6H)‑ones

ACS infectious diseases, 2018-04, Vol.4 (4), p.605-619

2018

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Synthesis and antiproliferative activity of 6-phenylaminopurines

European journal of medicinal chemistry, 2014-11, Vol.87, p.421-428

2014

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Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase

European journal of medicinal chemistry, 2014-07, Vol.82, p.459-465

2014

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Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications

Current pharmaceutical design, 2012, Vol.18 (20), p.2981-2994

2012

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9-Arylpurines as a Novel Class of Enterovirus Inhibitors

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.316-324

2010

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Targeting the colchicine site in tubulin through cyclohexanedione derivatives

RSC advances, 2016-01, Vol.6 (23), p.19492-19506

2016

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Efficient synthesis and anti-enteroviral activity of 9-arylpurines

European journal of medicinal chemistry, 2012-03, Vol.49, p.279-288

2012

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Intramolecular Cation−π Interactions As the Driving Force To Restrict the Conformation of Certain Nucleosides

Journal of organic chemistry, 2010-03, Vol.75 (6), p.1974-1981

2010

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Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): Present and future

Medicinal research reviews, 2008-09, Vol.28 (5), p.797-820

2008

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5‘-O-Tritylinosine and Analogues as Allosteric Inhibitors of Human Thymidine Phosphorylase

Journal of medicinal chemistry, 2006-09, Vol.49 (18), p.5562-5570

2006

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Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

Identification of [1,2,3]Triazolo[4,5‑d]pyrimidin-7(6H)‑ones as Novel Inhibitors of Chikungunya Virus Replication

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

Antivirals against (Re)emerging Flaviviruses: Should We Target the Virus or the Host?

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1

Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation

Novel Colchicine-Site Binders with a Cyclohexanedione Scaffold Identified through a Ligand-Based Virtual Screening Approach

Chikungunya virus drug discovery: still a long way to go?

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T‑cell Acute Lymphoblastic Leukemia

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091

Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity

Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity

Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3‑Aryl-[1,2,3]triazolo[4,5‑d]pyrimidin-7(6H)‑ones

Synthesis and antiproliferative activity of 6-phenylaminopurines

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase

Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications

9-Arylpurines as a Novel Class of Enterovirus Inhibitors

Targeting the colchicine site in tubulin through cyclohexanedione derivatives

Efficient synthesis and anti-enteroviral activity of 9-arylpurines

Intramolecular Cation−π Interactions As the Driving Force To Restrict the Conformation of Certain Nucleosides

Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): Present and future

5‘-O-Tritylinosine and Analogues as Allosteric Inhibitors of Human Thymidine Phosphorylase

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