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Screening out irrelevant cell-based models of disease

Nature reviews. Drug discovery, 2016-11, Vol.15 (11), p.751-769

2016

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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

Archives of toxicology, 2014-05, Vol.88 (5), p.1083-1095

2014

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3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis

SLAS DISCOVERY: Advancing the Science of Drug Discovery, 2019-07, Vol.24 (6), p.615-627

2019

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3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

PloS one, 2020-08, Vol.15 (8), p.e0235319

2020

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Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Scientific reports, 2021-03, Vol.11 (1), p.7259-7259, Article 7259

2021

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Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues

PloS one, 2014-10, Vol.9 (10), p.e109688

2014

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Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

Breast cancer research : BCR, 2011-05, Vol.13 (3), p.R52-R52, Article R52

2011

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High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Archives of toxicology, 2019-10, Vol.93 (10), p.2895-2911

2019

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A 3D human co-culture to model neuron-astrocyte interactions in tauopathies

Biological procedures online, 2023-02, Vol.25 (1), p.4-4, Article 4

2023

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Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility

Antibodies (Basel), 2018-03, Vol.7 (2), p.15

2018

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Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective

Scientific reports, 2020-02, Vol.10 (1), p.1672-1672, Article 1672

2020

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Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Nature cancer, 2022-04, Vol.3 (4), p.418

2022

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Rap1 Regulates E-cadherin-mediated Cell-Cell Adhesion

The Journal of biological chemistry, 2004-08, Vol.279 (34), p.35127-35132

2004

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Application of siRNA in targeting protein expression in kidney disease

Advanced drug delivery reviews, 2010-11, Vol.62 (14), p.1378-1389

2010

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Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

Molecular cancer, 2015-07, Vol.14 (1), p.147-147, Article 147

2015

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Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium

Journal of the American Society of Nephrology, 2014-07, Vol.25 (7), p.1474-1485

2014

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Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins

Molecular and Cellular Biology, 2010-11, Vol.30 (22), p.5421-5431

2010

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Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma

The Journal of pathology, 2015-07, Vol.236 (3), p.348-359

2015

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Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles

EBioMedicine, 2020-01, Vol.51, p.102585-102585, Article 102585

2020

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Calcium Signaling Regulates Translocation and Activation of Rac

The Journal of biological chemistry, 2003-10, Vol.278 (41), p.39413-39421

2003

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963 TME Immune-profiling of ex vivo tumor tissues and their functional responses to immuno-oncology treatments

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1070-A1070

2023

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cAMP signalling protects proximal tubular epithelial cells from cisplatin‐induced apoptosis via activation of Epac

British journal of pharmacology, 2012-02, Vol.165 (4b), p.1137-1150

2012

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Activation of Rac and Cdc42 by integrins mediates cell spreading

Molecular biology of the cell, 1998-07, Vol.9 (7), p.1863-1871

1998

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Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

Journal of biomolecular screening, 2016-10, Vol.21 (9), p.912-922

2016

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77 Analyzing effects of immunotherapies, such as bispecific antibodies and cellular therapy, targeting EGFR expression with a high content screening platform in patient-derived organoids

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A87-A87

2023

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Screening out irrelevant cell-based models of disease

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

A 3D human co-culture to model neuron-astrocyte interactions in tauopathies

Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility

Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Rap1 Regulates E-cadherin-mediated Cell-Cell Adhesion

Application of siRNA in targeting protein expression in kidney disease

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium

Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins

Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma

Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles

Calcium Signaling Regulates Translocation and Activation of Rac

963 TME Immune-profiling of ex vivo tumor tissues and their functional responses to immuno-oncology treatments

cAMP signalling protects proximal tubular epithelial cells from cisplatin‐induced apoptosis via activation of Epac

Activation of Rac and Cdc42 by integrins mediates cell spreading

Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

77 Analyzing effects of immunotherapies, such as bispecific antibodies and cellular therapy, targeting EGFR expression with a high content screening platform in patient-derived organoids

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