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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1862-1878

2015

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Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides

Molecules (Basel, Switzerland), 2022-04, Vol.27 (8), p.2413

2022

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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

PLoS pathogens, 2015-06, Vol.11 (6), p.e1004995-e1004995

2015

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Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

PloS one, 2016-05, Vol.11 (5), p.e0154097-e0154097

2016

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A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

Antimicrobial Agents and Chemotherapy, 2004-10, Vol.48 (10), p.3944-3953

2004

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Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Journal of medicinal chemistry, 2004-10, Vol.47 (21), p.5284-5297

2004

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Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Journal of medicinal chemistry, 2004-04, Vol.47 (9), p.2283-2295

2004

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2‘-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

Organic letters, 2003-06, Vol.5 (12), p.2017-2020

2003

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Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4611-4624

2016

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Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4555-4570

2019

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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10380-10395

2020

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2;-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Antisense Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

Organic letters, 2016-04, Vol.5 (12)

2016

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2′- O -Carbamate-containing oligonucleotides: synthesis and properties

Tetrahedron letters, 2001-12, Vol.42 (50), p.8777-8780

2001

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Synthesis of AZT 5‘-Triphosphate Mimics and Their Inhibitory Effects on HIV-1 Reverse Transcriptase

Journal of medicinal chemistry, 2004-12, Vol.47 (27), p.6902-6913

2004

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Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

Journal of the American Chemical Society, 2004-11, Vol.126 (46), p.15006-15007

2004

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Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.1199-1210

2005

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Synthesis of 2‘,3‘-Dideoxynucleoside 5‘-α-P-Borano-β,γ-(difluoromethylene)triphosphates and Their Inhibition of HIV-1 Reverse Transcriptase

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2695-2700

2005

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A New Series of Tricyclic Nucleosides as Potent Inhibitors of Hepatitis C Virus RNA Replication: Design, Synthesis and Structure–Activity Relationships

Antiviral research, 2009-05, Vol.82 (2), p.A29-A29

2009

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2′,3′-Dideoxynucleoside 5′-β,γ-(Difluoromethylene) Triphosphates With α-P-Thio or α-P-Seleno Modifications: Synthesis and Their Inhibition of HIV-1 Reverse Transcriptase

Nucleosides, nucleotides & nucleic acids, 2005-09, Vol.24 (10-12), p.1651-1664

2005

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Synthesis and Biological Activity of 7-Deaza-7-ethynyl-2′-deoxy-2′-fluoro-2′-C-methyladenosine and its 2′-C-Methyl-ribo Analogue

Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.643-644

2008

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Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (3), p.179-189

2005

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Synthesis of 5′-Triphosphate Mimics (P3Ms) of 3′-Azido-3′,5′-Dideoxythymidine and 3′,5′-Dideoxy-5′-Difluoromethylenethymidine as HIV-1 Reverse Transcriptase Inhibitors

Nucleosides, nucleotides & nucleic acids, 2005-03, Vol.24 (3), p.179-189

2005

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A new approach for the synthesis of 3′-deoxy-3′- C-formyl-ribonucleosides and the synthesis of alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2′-OH and 2′-OMe groups

Tetrahedron letters, 2000-12, Vol.41 (51), p.9967-9971

2000

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CHIMERIC RNA WITH MODIFIED BACKBONES: ALTERNATING METHYLENE(METHYLIMINO) LINKED PHOSPHODIESTER BACKBONE OLIGONUCLEOTIDES WITH 2′-OH AND 2′-OMe GROUPS

Nucleosides, nucleotides & nucleic acids, 2001-04, Vol.20 (4-7), p.995-997

2001

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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

2‘-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues

Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection

Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

2;-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Antisense Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

2′- O -Carbamate-containing oligonucleotides: synthesis and properties

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate: e1004995

Synthesis of AZT 5‘-Triphosphate Mimics and Their Inhibitory Effects on HIV-1 Reverse Transcriptase

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

Synthesis of 2‘,3‘-Dideoxynucleoside 5‘-α-P-Borano-β,γ-(difluoromethylene)triphosphates and Their Inhibition of HIV-1 Reverse Transcriptase

A New Series of Tricyclic Nucleosides as Potent Inhibitors of Hepatitis C Virus RNA Replication: Design, Synthesis and Structure–Activity Relationships

2′,3′-Dideoxynucleoside 5′-β,γ-(Difluoromethylene) Triphosphates With α-P-Thio or α-P-Seleno Modifications: Synthesis and Their Inhibition of HIV-1 Reverse Transcriptase

Synthesis and Biological Activity of 7-Deaza-7-ethynyl-2′-deoxy-2′-fluoro-2′-C-methyladenosine and its 2′-C-Methyl-ribo Analogue

Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors

Synthesis of 5′-Triphosphate Mimics (P3Ms) of 3′-Azido-3′,5′-Dideoxythymidine and 3′,5′-Dideoxy-5′-Difluoromethylenethymidine as HIV-1 Reverse Transcriptase Inhibitors

A new approach for the synthesis of 3′-deoxy-3′- C-formyl-ribonucleosides and the synthesis of alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2′-OH and 2′-OMe groups

CHIMERIC RNA WITH MODIFIED BACKBONES: ALTERNATING METHYLENE(METHYLIMINO) LINKED PHOSPHODIESTER BACKBONE OLIGONUCLEOTIDES WITH 2′-OH AND 2′-OMe GROUPS

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