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Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

Journal of hepatology, 2016, Vol.64 (2), p.S404-S404

2016

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P0682 : Preclinical characterization of AL-335, a potent uridine based nucleoside polymerase inhibitor for the treatment of chronic hepatitis C

Journal of hepatology, 2015-04, Vol.62, p.S577-S578

2015

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A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

Antimicrobial Agents and Chemotherapy, 2004-10, Vol.48 (10), p.3944-3953

2004

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Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Journal of medicinal chemistry, 2004-10, Vol.47 (21), p.5284-5297

2004

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Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Journal of medicinal chemistry, 2004-04, Vol.47 (9), p.2283-2295

2004

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THU-226 - Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

Journal of hepatology, 2016, Vol.64 (2), p.S404-S404

2016

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2'-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Antisense Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

Organic letters, 2010-03, Vol.5 ((12) ; 01, 2003)

2010

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Synthesis of AZT 5‘-Triphosphate Mimics and Their Inhibitory Effects on HIV-1 Reverse Transcriptase

Journal of medicinal chemistry, 2004-12, Vol.47 (27), p.6902-6913

2004

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Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2'-O-Modified Nucleic Acid Analogs

Journal of the American Chemical Society, 2010-03, Vol.126 (2004)

2010

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Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

Journal of the American Chemical Society, 2004-11, Vol.126 (46), p.15006-15007

2004

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2‘-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

Organic letters, 2003-06, Vol.5 (12), p.2017-2020

2003

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CHIMERIC RNA WITH MODIFIED BACKBONES: ALTERNATING METHYLENE(METHYLIMINO) LINKED PHOSPHODIESTER BACKBONE OLIGONUCLEOTIDES WITH 2′-OH AND 2′-OMe GROUPS

Nucleosides, nucleotides & nucleic acids, 2001-04, Vol.20 (4-7), p.995-997

2001

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Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.1199-1210

2005

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Synthesis of 2‘,3‘-Dideoxynucleoside 5‘-α-P-Borano-β,γ-(difluoromethylene)triphosphates and Their Inhibition of HIV-1 Reverse Transcriptase

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2695-2700

2005

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A New Series of Tricyclic Nucleosides as Potent Inhibitors of Hepatitis C Virus RNA Replication: Design, Synthesis and Structure–Activity Relationships

Antiviral research, 2009-05, Vol.82 (2), p.A29-A29

2009

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2′- O -Carbamate-containing oligonucleotides: synthesis and properties

Tetrahedron letters, 2001-12, Vol.42 (50), p.8777-8780

2001

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2′,3′-Dideoxynucleoside 5′-β,γ-(Difluoromethylene) Triphosphates With α-P-Thio or α-P-Seleno Modifications: Synthesis and Their Inhibition of HIV-1 Reverse Transcriptase

Nucleosides, nucleotides & nucleic acids, 2005-09, Vol.24 (10-12), p.1651-1664

2005

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Reactions of 5-β-D-Ribofuranosyl Tetrazoles with Dipolarophiles

Nucleosides & nucleotides, 1991-01, Vol.10 (1-3), p.729-730

1991

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Synthesis and Biological Activity of 7-Deaza-7-ethynyl-2′-deoxy-2′-fluoro-2′-C-methyladenosine and its 2′-C-Methyl-ribo Analogue

Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.643-644

2008

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Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (3), p.179-189

2005

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2',3'-Dideoxynucleoside 5'- beta ,y-(Difluoromethylene) Triphosphates With alpha -P-Thio or alpha -P-Seleno Modifications: Synthesis and Their Inhibition of HIV-1 Reverse Transcriptase

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (10-12), p.1651-1664

2005

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A new approach for the synthesis of 3′-deoxy-3′- C-formyl-ribonucleosides and the synthesis of alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2′-OH and 2′-OMe groups

Tetrahedron letters, 2000-12, Vol.41 (51), p.9967-9971

2000

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Synthesis of 5′-Triphosphate Mimics (P3Ms) of 3′-Azido-3′,5′-Dideoxythymidine and 3′,5′-Dideoxy-5′-Difluoromethylenethymidine as HIV-1 Reverse Transcriptase Inhibitors

Nucleosides, nucleotides & nucleic acids, 2005-03, Vol.24 (3), p.179-189

2005

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Preparation and Utility of 5-β-D-Ribofuranosyl-1H-tetrazole as a Key Synthon for C-Nucleoside Synthesis

Nucleosides & nucleotides, 1994-12, Vol.13 (10), p.2209-2244

1994

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Carbohydrate Modifications in Antisense Oligonucleotide Therapy: New Kids on the Block

Nucleosides & nucleotides, 1999-06, Vol.18 (6-7), p.1737-1746

1999

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Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

P0682 : Preclinical characterization of AL-335, a potent uridine based nucleoside polymerase inhibitor for the treatment of chronic hepatitis C

A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

THU-226 - Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

2'-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Antisense Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

Synthesis of AZT 5‘-Triphosphate Mimics and Their Inhibitory Effects on HIV-1 Reverse Transcriptase

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2'-O-Modified Nucleic Acid Analogs

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

2‘-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects

CHIMERIC RNA WITH MODIFIED BACKBONES: ALTERNATING METHYLENE(METHYLIMINO) LINKED PHOSPHODIESTER BACKBONE OLIGONUCLEOTIDES WITH 2′-OH AND 2′-OMe GROUPS

Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

Synthesis of 2‘,3‘-Dideoxynucleoside 5‘-α-P-Borano-β,γ-(difluoromethylene)triphosphates and Their Inhibition of HIV-1 Reverse Transcriptase

A New Series of Tricyclic Nucleosides as Potent Inhibitors of Hepatitis C Virus RNA Replication: Design, Synthesis and Structure–Activity Relationships

2′- O -Carbamate-containing oligonucleotides: synthesis and properties

2′,3′-Dideoxynucleoside 5′-β,γ-(Difluoromethylene) Triphosphates With α-P-Thio or α-P-Seleno Modifications: Synthesis and Their Inhibition of HIV-1 Reverse Transcriptase

Reactions of 5-β-D-Ribofuranosyl Tetrazoles with Dipolarophiles

Synthesis and Biological Activity of 7-Deaza-7-ethynyl-2′-deoxy-2′-fluoro-2′-C-methyladenosine and its 2′-C-Methyl-ribo Analogue

Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors

2',3'-Dideoxynucleoside 5'- beta ,y-(Difluoromethylene) Triphosphates With alpha -P-Thio or alpha -P-Seleno Modifications: Synthesis and Their Inhibition of HIV-1 Reverse Transcriptase

A new approach for the synthesis of 3′-deoxy-3′- C-formyl-ribonucleosides and the synthesis of alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2′-OH and 2′-OMe groups

Synthesis of 5′-Triphosphate Mimics (P3Ms) of 3′-Azido-3′,5′-Dideoxythymidine and 3′,5′-Dideoxy-5′-Difluoromethylenethymidine as HIV-1 Reverse Transcriptase Inhibitors

Preparation and Utility of 5-β-D-Ribofuranosyl-1H-tetrazole as a Key Synthon for C-Nucleoside Synthesis

Carbohydrate Modifications in Antisense Oligonucleotide Therapy: New Kids on the Block

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