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Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)‑2-((S)‑Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist

Journal of medicinal chemistry, 2024-01, Vol.67 (2), p.1314-1326

2024

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Dimers and beyond: The functional puzzles of class C GPCRs

Pharmacology & therapeutics (Oxford), 2011-04, Vol.130 (1), p.9-25

2011

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Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

Nature communications, 2022-10, Vol.13 (1), p.6365-6365, Article 6365

2022

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Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

eLife, 2017-06, Vol.6

2017

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Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far?

International journal of molecular sciences, 2023-01, Vol.24 (3), p.2632

2023

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GPCR interaction as a possible way for allosteric control between receptors

Molecular and cellular endocrinology, 2019-04, Vol.486, p.89-95

2019

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The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication

AIDS (London), 2024-08, Vol.38 (10), p.1449-1459

2024

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SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome

Journal of neurochemistry, 2022-03, Vol.160 (6), p.625-642

2022

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Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists

European journal of medicinal chemistry, 2024-02, Vol.266, p.116157-116157, Article 116157

2024

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A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers

Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (33), p.1

2021

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Different EGF‐induced receptor dimer conformations for signaling and internalization

The FASEB journal, 2024-01, Vol.38 (1), p.e23356-n/a

2024

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Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

Nature methods, 2008-06, Vol.5 (6), p.561-567

2008

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Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors

The FASEB journal, 2014-12, Vol.28 (12), p.5148-5162

2014

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Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

Pharmacology & therapeutics (Oxford), 2003-06, Vol.98 (3), p.325-354

2003

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Closed state of both binding domains of homodimeric mGlu receptors is required for full activity

Nature structural & molecular biology, 2004-08, Vol.11 (8), p.706-713

2004

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G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

The FASEB journal, 2021-07, Vol.35 (7), p.e21668-n/a

2021

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The chemokine CXC4 and CC2 receptors form homo‐ and heterooligomers that can engage their signaling G‐protein effectors and βarrestin

The FASEB journal, 2014-10, Vol.28 (10), p.4509-4523

2014

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Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor

Molecular pharmacology, 2019-08, Vol.96 (2), p.233-246

2019

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The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors

Neuropharmacology, 2011-01, Vol.60 (1), p.82-92

2011

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Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser280 by Hallucinogenic versus Nonhallucinogenic Agonists

Molecular & cellular proteomics, 2014-05, Vol.13 (5), p.1273-1285

2014

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Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics

Scientific reports, 2018-07, Vol.8 (1), p.10414-15, Article 10414

2018

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Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective

Current neuropharmacology, 2007-09, Vol.5 (3), p.195-201

2007

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The oligomeric state sets GABA(B) receptor signalling efficacy

The EMBO journal, 2011-05, Vol.30 (12), p.2336

2011

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A proteomic analysis reveals the interaction of GluK1 ionotropic kainate receptor subunits with Go proteins

The Journal of neuroscience, 2015-04, Vol.35 (13), p.5171-5179

2015

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Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling

AIDS (London), 2017-11, Vol.31 (18), p.2443-2454

2017

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Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)‑2-((S)‑Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist

Dimers and beyond: The functional puzzles of class C GPCRs

Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far?

GPCR interaction as a possible way for allosteric control between receptors

The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication

SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome

Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists

A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers

Different EGF‐induced receptor dimer conformations for signaling and internalization

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

Closed state of both binding domains of homodimeric mGlu receptors is required for full activity

G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

The chemokine CXC4 and CC2 receptors form homo‐ and heterooligomers that can engage their signaling G‐protein effectors and βarrestin

Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor

The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors

Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser280 by Hallucinogenic versus Nonhallucinogenic Agonists

Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics

Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective

The oligomeric state sets GABA(B) receptor signalling efficacy

A proteomic analysis reveals the interaction of GluK1 ionotropic kainate receptor subunits with Go proteins

Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling

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