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Molecular engineering and design of therapeutic antibodies

Current opinion in immunology, 2008-08, Vol.20 (4), p.460-470

Presta, Leonard G

2008

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Engineering of therapeutic antibodies to minimize immunogenicity and optimize function

Advanced drug delivery reviews, 2006-08, Vol.58 (5), p.640-656

Presta, Leonard G.

2006

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TCR mimic compounds for pHLA targeting with high potency modalities in oncology

Frontiers in oncology, 2022-10, Vol.12, p.1027548-1027548

2022

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Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease

International immunology, 2006-12, Vol.18 (12), p.1759-1769

2006

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Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Nature medicine, 2000-04, Vol.6 (4), p.443-446

2000

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Selection, design, and engineering of therapeutic antibodies

Journal of Allergy and Clinical Immunology, 2005-10, Vol.116 (4), p.731-736

2005

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Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice

Blood, 2014-04, Vol.123 (14), p.2172-2180

2014

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Isomerization of an Aspartic Acid Residue in the Complementarity-Determining Regions of a Recombinant Antibody to Human IgE: Identification and Effect on Binding Affinity

Biochemistry (Easton), 1996-02, Vol.35 (6), p.1897-1903

1996

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Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders

Cancer research (Chicago, Ill.), 1997-10, Vol.57 (20), p.4593-4599

1997

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Mapping of the C1q Binding Site on Rituxan, a Chimeric Antibody with a Human IgG1 Fc

The Journal of immunology (1950), 2000-04, Vol.164 (8), p.4178-4184

2000

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Engineered Antibodies with Increased Activity to Recruit Complement

The Journal of immunology (1950), 2001-02, Vol.166 (4), p.2571-2575

2001

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Engineering antibodies for therapy

Current pharmaceutical biotechnology, 2002-09, Vol.3 (3), p.237-256

Presta, Leonard G

2002

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An efficient route to human bispecific IgG

Nature biotechnology, 1998-07, Vol.16 (7), p.677-681

1998

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Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays

Journal of immunological methods, 2011-02, Vol.365 (1-2), p.132-141

2011

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Identification of IgG1 variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays

Journal of immunological methods, 2011-02, Vol.365 (1-2), p.132-141

2011

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Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis

Journal of molecular biology, 2002-07, Vol.320 (2), p.415-428

2002

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Antibody Humanization Using Monovalent Phage Display

The Journal of biological chemistry, 1997-04, Vol.272 (16), p.10678-10684

1997

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Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

The Journal of biological chemistry, 2002-07, Vol.277 (30), p.26733-26740

2002

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Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20

Journal of immunological methods, 2004-11, Vol.294 (1), p.189-197

2004

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Celebrating diversity and mimicking maturation

Nature biotechnology, 2002-11, Vol.20 (11), p.1096-1097

Presta, Leonard G

2002

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Remodeling domain interfaces to enhance heterodimer formation

Protein science, 1997-04, Vol.6 (4), p.781-788

1997

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Mapping the Charged Residues in the Second Immunoglobulin-like Domain of the Vascular Endothelial Growth Factor/Placenta Growth Factor Receptor Flt-1 Required for Binding and Structural Stability

The Journal of biological chemistry, 1998-02, Vol.273 (6), p.3216-3222

1998

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High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors

The Journal of biological chemistry, 1998-03, Vol.273 (10), p.5829-5840

1998

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P- and E-Selectin Use Common Sites for Carbohydrate Ligand Recognition and Cell Adhesion

The Journal of cell biology, 1993-03, Vol.120 (5), p.1227-1235

1993

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Molecular engineering and design of therapeutic antibodies

Engineering of therapeutic antibodies to minimize immunogenicity and optimize function

TCR mimic compounds for pHLA targeting with high potency modalities in oncology

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Selection, design, and engineering of therapeutic antibodies

Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

Isomerization of an Aspartic Acid Residue in the Complementarity-Determining Regions of a Recombinant Antibody to Human IgE: Identification and Effect on Binding Affinity

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders

Mapping of the C1q Binding Site on Rituxan, a Chimeric Antibody with a Human IgG1 Fc

Engineered Antibodies with Increased Activity to Recruit Complement

Engineering antibodies for therapy

An efficient route to human bispecific IgG

Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays

Identification of IgG1 variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays

Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis

Antibody Humanization Using Monovalent Phage Display

Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20

Celebrating diversity and mimicking maturation

Remodeling domain interfaces to enhance heterodimer formation

Mapping the Charged Residues in the Second Immunoglobulin-like Domain of the Vascular Endothelial Growth Factor/Placenta Growth Factor Receptor Flt-1 Required for Binding and Structural Stability

High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors

P- and E-Selectin Use Common Sites for Carbohydrate Ligand Recognition and Cell Adhesion

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