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Anti-Drug Antibodies: Emerging Approaches to Predict, Reduce or Reverse Biotherapeutic Immunogenicity

Antibodies (Basel), 2018-05, Vol.7 (2), p.19

Pratt, Kathleen P.

2018

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Tolerating Factor VIII: Recent Progress

Frontiers in immunology, 2020-01, Vol.10, p.2991-2991

2020

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Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

Frontiers in immunology, 2020-01, Vol.10, p.3078

2020

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Editorial: Tolerating Factor VIII: Novel Strategies to Prevent and Reverse Neutralizing Anti-FVIII Antibodies

Frontiers in immunology, 2021-01, Vol.11, p.639386-639386

2021

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Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

PloS one, 2018-11, Vol.13 (11), p.e0206654-e0206654

2018

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Factor VIII forges its own path

Blood, 2023-07, Vol.142 (3), p.217-219

Pratt, Kathleen P.

2023

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Hemophilia A subjects with an intron-22 gene inversion mutation show CD4 + T-effector responses to multiple epitopes in FVIII

Frontiers in immunology, 2023-03, Vol.14, p.1128641-1128641

2023

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The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections

Human vaccines & immunotherapeutics, 2020-09, Vol.16 (9), p.2222-2237

2020

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Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include Up-Regulated Innate Immune Modulators

Frontiers in immunology, 2020-06, Vol.11, p.1219-1219

2020

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Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

Human vaccines & immunotherapeutics, 2022-11, Vol.18 (5), p.2048622-2048622

2022

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Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A

Blood, 2016-10, Vol.128 (16), p.2007-2016

2016

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High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Blood, 2014-04, Vol.123 (17), p.2732-2739

2014

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Race, ethnicity, F8 variants, and inhibitor risk: analysis of the “My Life Our Future” hemophilia A database

Journal of thrombosis and haemostasis, 2023-04, Vol.21 (4), p.800-813

2023

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Marginal immunogenicity of factor VIII

Blood, 2017-12, Vol.130 (23), p.2450-2451

Pratt, Kathleen P.

2017

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Corrigendum to ‘Race, ethnicity, F8 variants and inhibitor risk: Analysis of the “My Life Our Future” Hemophilia A database’ [Journal of Thrombosis and Haemostasis Volume 21, Issue 4, April 2023, Pages 800-813]

Journal of thrombosis and haemostasis, 2023-06, Vol.21 (6), p.1684-1685

2023

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Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance

PloS one, 2013-05, Vol.8 (5), p.e61120

2013

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Engineering less immunogenic and antigenic FVIII proteins

Cellular immunology, 2016-03, Vol.301, p.12-17

Pratt, Kathleen P.

2016

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Structure of the C2 domain of human factor VIII at 1.5 resolution

Nature (London), 1999-11, Vol.402 (6760), p.439-442

1999

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fVIII binds platelets + fibrin: no PS

Blood, 2015-09, Vol.126 (10), p.1158-1159

Pratt, Kathleen P.

2015

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The factor VIII C1 domain contributes to platelet binding

Blood, 2008-01, Vol.111 (1), p.200-208

2008

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Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

Blood, 2015-02, Vol.125 (7), p.1107-1115

2015

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Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody

PloS one, 2015, Vol.10 (1), p.e0116577-e0116577

2015

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Inhibitors—Recent insights

Haemophilia : the official journal of the World Federation of Hemophilia, 2021-02, Vol.27 (S3), p.28-36

2021

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Progress toward inducing immunologic tolerance to factor VIII

Blood, 2013-05, Vol.121 (22), p.4449-4456

2013

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Hemophilia A Inhibitor Treatment: The Promise of Engineered T Cell Therapy

Translational research : the journal of laboratory and clinical medicine, 2017-09, Vol.187, p.44-52

2017

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Anti-Drug Antibodies: Emerging Approaches to Predict, Reduce or Reverse Biotherapeutic Immunogenicity

Tolerating Factor VIII: Recent Progress

Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

Editorial: Tolerating Factor VIII: Novel Strategies to Prevent and Reverse Neutralizing Anti-FVIII Antibodies

Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

Factor VIII forges its own path

Hemophilia A subjects with an intron-22 gene inversion mutation show CD4 + T-effector responses to multiple epitopes in FVIII

The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections

Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include Up-Regulated Innate Immune Modulators

Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Race, ethnicity, F8 variants, and inhibitor risk: analysis of the “My Life Our Future” hemophilia A database

Marginal immunogenicity of factor VIII

Corrigendum to ‘Race, ethnicity, F8 variants and inhibitor risk: Analysis of the “My Life Our Future” Hemophilia A database’ [Journal of Thrombosis and Haemostasis Volume 21, Issue 4, April 2023, Pages 800-813]

Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance

Engineering less immunogenic and antigenic FVIII proteins

Structure of the C2 domain of human factor VIII at 1.5 resolution

fVIII binds platelets + fibrin: no PS

The factor VIII C1 domain contributes to platelet binding

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody

Inhibitors—Recent insights

Progress toward inducing immunologic tolerance to factor VIII

Hemophilia A Inhibitor Treatment: The Promise of Engineered T Cell Therapy

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