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Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity

PloS one, 2011-07, Vol.6 (7), p.e21917

2011

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Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury

The American journal of pathology, 2013-03, Vol.182 (3), p.928-939

2013

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Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine

Analytical chemistry (Washington), 2011-06, Vol.83 (11), p.4228-4236

2011

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Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death

International journal of molecular sciences, 2022-03, Vol.23 (6), p.3049

2022

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Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs

Anti-cancer agents in medicinal chemistry, 2012-12, Vol.12 (10), p.1211

2012

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Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds

Forensic science international, 2013-12, Vol.233 (1), p.416-422

2013

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Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity

Pharmacology, biochemistry and behavior, 2020-08, Vol.195, p.172949-172949, Article 172949

2020

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The tamoxifen derivative ridaifen-B is a high affinity selective CB 2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects

Toxicology and applied pharmacology, 2018-08, Vol.353, p.31-42

2018

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Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics

Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4820

2020

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Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats

Frontiers in pharmacology, 2023-05, Vol.14, p.1123261-1123261

2023

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Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development

PloS one, 2016-12, Vol.11 (12), p.e0167240

2016

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Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids

Drug metabolism and disposition, 2009-07, Vol.37 (7), p.1496

2009

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CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen

Biochemical and biophysical research communications, 2013-11, Vol.441 (2), p.339-343

2013

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Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity

PloS one, 2015-10, Vol.10 (10), p.e0141600

2015

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Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors

The Journal of pharmacology and experimental therapeutics, 2005-11, Vol.315 (2), p.828

2005

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Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC

Frontiers in pharmacology, 2018-09, Vol.9, p.1084-1084

2018

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Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ(9)-THC: mechanism underlying greater toxicity?

Life sciences (1973), 2014-02, Vol.97 (1), p.45

2014

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Synthetic Pot: Not Your Grandfather’s Marijuana

Trends in pharmacological sciences (Regular ed.), 2017-03, Vol.38 (3), p.257-276

2017

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Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes

Metabolites, 2022-08, Vol.12 (8), p.773

2022

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The K2/Spice Phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products

Drug metabolism reviews, 2014-02, Vol.46 (1), p.72-85

2014

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Preface to DMR special edition 'Cannabinoid receptors and ligands: therapeutic drug development and abuse potential'

Drug metabolism reviews, 2018-01, Vol.50 (1), p.1-2

Prather, Paul L.

2018

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Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135)

Pharmacology research & perspectives, 2020-02, Vol.8 (1), p.e00561-n/a

2020

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The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists

The Journal of pharmacology and experimental therapeutics, 2009-07, Vol.330 (1), p.31

2009

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Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors

Toxicological sciences, 2022-04, Vol.187 (1), p.175-185

2022

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The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.868

2005

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Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity

Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury

Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine

Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death

Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs

Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds

Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity

The tamoxifen derivative ridaifen-B is a high affinity selective CB 2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects

Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics

Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats

Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development

Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids

CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen

Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity

Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors

Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC

Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ(9)-THC: mechanism underlying greater toxicity?

Synthetic Pot: Not Your Grandfather’s Marijuana

Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes

The K2/Spice Phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products

Preface to DMR special edition 'Cannabinoid receptors and ligands: therapeutic drug development and abuse potential'

Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135)

The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists

Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors

The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors

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