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Signal Peptide Peptidase and γ-Secretase Share Equivalent Inhibitor Binding Pharmacology

The Journal of biological chemistry, 2007-12, Vol.282 (51), p.36829-36836

2007

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Enantioselective synthesis of aminobenzazepinones

Tetrahedron letters, 2007-04, Vol.48 (15), p.2661-2665

2007

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Discovery of (S) -2 -( (S) -2 -(3,5 -difluorophenyl ) -2-hydroxyacetamido ) -N-( (S,Z) -3 -methyl -4 -oxo -4,5 -dihydro -3H-benzo[d|[1,2 ]diazepin -5 -yl )propanamide (BMS -433796 ) : A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.4006-4011

2007

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2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3535-3538

2004

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N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4432-4436

2007

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Hydroxytriamides as potent γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1917-1921

2004

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Discovery of ( S)-2-(( S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)- N-(( S, Z)-3-methyl-4-oxo-4,5-dihydro-3 H-benzo[ d][1,2]diazepin-5-yl)propanamide (BMS-433796): A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (14), p.4006-4011

2007

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Corrigendum to “Hydroxytriamides as potent γ-secretase inhibitors”: [Bioorg. Med. Chem. Lett. 14 (2004) 1917]

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3361-3361

2004

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Achiral internucleoside linkages 3: CH 2NHCH 2 linkage

Bioorganic & medicinal chemistry letters, 1995, Vol.5 (4), p.411-414

1995

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Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (4), p.315-318

1995

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Achiral internucleoside linkages 2: O-CH 2-CH 2 linkage

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (12), p.1497-1500

1994

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The synthesis of modified achiral internucleoside linkages : -NHCH2CH2-linked oligonucleosides

Tetrahedron letters, 1993-09, Vol.34 (38), p.6017-6020

1993

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Achiral internucleoside linkages : CH2-CH2-NH and NH-CH2-CH2 linkages

Bioorganic & medicinal chemistry letters, 1993-12, Vol.3 (12), p.2771-2776

1993

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Achiral internucleoside linkages 2: O-CH2-CH2 linkage

Bioorganic & medicinal chemistry letters, 1994-06, Vol.4 (12), p.1497-1500

1994

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The synthesis of modified achiral internucleoside linkages: -NHCH 2CH 2- linked oligonucleosides

Tetrahedron letters, 1993, Vol.34 (38), p.6017-6020

1993

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Achiral internucleoside linkages: CH 2-CH 2-NH and nH-CH 2-CH 2 linkages

Bioorganic & medicinal chemistry letters, 1993, Vol.3 (12), p.2771-2776

1993

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Achiral internucleoside linkages 3: CH2NHCH2 linkage

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (4), p.411-414

1995

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Signal Peptide Peptidase and γ-Secretase Share Equivalent Inhibitor Binding Pharmacology

Enantioselective synthesis of aminobenzazepinones

Discovery of (S) -2 -( (S) -2 -(3,5 -difluorophenyl ) -2-hydroxyacetamido ) -N-( (S,Z) -3 -methyl -4 -oxo -4,5 -dihydro -3H-benzo[d|[1,2 ]diazepin -5 -yl )propanamide (BMS -433796 ) : A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease

2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase

N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors

Hydroxytriamides as potent γ-secretase inhibitors

Discovery of ( S)-2-(( S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)- N-(( S, Z)-3-methyl-4-oxo-4,5-dihydro-3 H-benzo[ d][1,2]diazepin-5-yl)propanamide (BMS-433796): A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer’s disease

Corrigendum to “Hydroxytriamides as potent γ-secretase inhibitors”: [Bioorg. Med. Chem. Lett. 14 (2004) 1917]

Achiral internucleoside linkages 3: CH 2NHCH 2 linkage

Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

Achiral internucleoside linkages 2: O-CH 2-CH 2 linkage

The synthesis of modified achiral internucleoside linkages : -NHCH2CH2-linked oligonucleosides

Achiral internucleoside linkages : CH2-CH2-NH and NH-CH2-CH2 linkages

Achiral internucleoside linkages 2: O-CH2-CH2 linkage

The synthesis of modified achiral internucleoside linkages: -NHCH 2CH 2- linked oligonucleosides

Achiral internucleoside linkages: CH 2-CH 2-NH and nH-CH 2-CH 2 linkages

Achiral internucleoside linkages 3: CH2NHCH2 linkage

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