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Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy

Chemical communications (Cambridge, England), 2021-09, Vol.57 (77), p.9798-986

2021

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In Vivo Gold Complex Catalysis within Live Mice

Angewandte Chemie International Edition, 2017-03, Vol.56 (13), p.3579-3584

International ed. in English, 2017

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Application of Acrolein Imines to Organic Synthesis, Biofunctional Studies, and Clinical Practice

Chemical record, 2021-04, Vol.21 (4), p.646-662

2021

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Emerging Technologies for Real‐Time Intraoperative Margin Assessment in Future Breast‐Conserving Surgery

Advanced science, 2020-05, Vol.7 (9), p.1901519-n/a

2020

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Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (24), p.115831-115831, Article 115831

2020

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Chemistry-driven translocation of glycosylated proteins in mice

Nature communications, 2024-10, Vol.15 (1), p.7409-15, Article 7409

2024

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The Second-Generation Click-to-Sense Probe for Intraoperative Diagnosis of Breast Cancer Tissues Based on Acrolein Targeting

Bulletin of the Chemical Society of Japan, 2022, Vol.95 (3), p.421-426

2022

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Unexplored Reactivity of N -Alkyl Unsaturated Imines: A Simple Procedure for Producing Optically Active 1,3-Diamines via a Stereocontrolled Formal [4+2] and [4+2+2] Iminocycloaddition

Bulletin of the Chemical Society of Japan, 2016-03, Vol.89 (3), p.337-345

2016

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Tetramethylrhodamine is an essential scaffold of azide probe in detecting cellular acrolein

Bioorganic & medicinal chemistry, 2019-06, Vol.27 (11), p.2228-2234

2019

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In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6

Bioscience, biotechnology, and biochemistry, 2019-06, Vol.83 (6), p.1011-1026

2019

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Enantioselective synthesis of cyclic and linear diamines by imine cycloadditions

Chirality (New York, N.Y.), 2020-09, Vol.32 (9), p.1160-1168

2020

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Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

Journal of experimental & clinical cancer research, 2017-02, Vol.36 (1), p.35-35, Article 35

2017

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Cascade Reaction in Human Live Tissue Allows Clinically Applicable Diagnosis of Breast Cancer Morphology

Advanced science, 2019-01, Vol.6 (2), p.1801479-n/a

2019

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Facile Access to Optically Active 2,6‐Dialkyl‐1,5‐Diazacyclooctanes

Chemistry, an Asian journal, 2019-11, Vol.14 (22), p.4048-4054

2019

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Metallic radionuclide-labeled tetrameric 2,6-diisopropylphenyl azides for cancer treatment

Chemical communications (Cambridge, England), 2024-03, Vol.6 (24), p.3291-3294

2024

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Uncatalyzed Click Reaction between Phenyl Azides and Acrolein: 4‑Formyl-1,2,3-Triazolines as “Clicked” Markers for Visualizations of Extracellular Acrolein Released from Oxidatively Stressed Cells

ACS sensors, 2016-05, Vol.1 (5), p.623-632

2016

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A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells

Organic & biomolecular chemistry, 2014-03, Vol.12 (9), p.1412-1418

2014

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In Vivo Synthetic Anticancer Approach by Resourcing Mouse Blood Albumin as a Biocompatible Artificial Metalloenzyme

Angewandte Chemie International Edition, 2024-10, Vol.63 (43), p.e202411225-n/a

International ed. in English, 2024

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Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation

Chemical science (Cambridge), 2021-04, Vol.12 (15), p.5438-5449

2021

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Inhibition of amyloid formation of amyloid β (1–42), amylin and insulin by 1,5-diazacyclooctanes, a spermine-acrolein conjugate

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116391-116391, Article 116391

2021

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Efficient synthesis of 2,6,9-triazabicyclo[3.3.1]nonanes through amine-mediated formal [4+4] reaction of unsaturated imines

Tetrahedron letters, 2012-10, Vol.53 (44), p.5899-5902

2012

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Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein

Chemical science (Cambridge), 2024-06, Vol.15 (25), p.9566-9573

2024

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A Strategy for Tumor Targeting by Higher‐Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N‐Glycan Molecules

Small (Weinheim an der Bergstrasse, Germany), 2020-11, Vol.16 (46), p.e2004831-n/a

2020

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Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses

Organic & biomolecular chemistry, 2016-01, Vol.14 (3), p.1013-1023

2016

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Characterization of Natural Human Nucleotide-binding Oligomerization Domain Protein 1 (Nod1) Ligands from Bacterial Culture Supernatant for Elucidation of Immune Modulators in the Environment

The Journal of biological chemistry, 2010-07, Vol.285 (31), p.23607-23613

2010

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Biofunctional chemistry and reactivity of biogenic acrolein for cancer diagnosis and therapy

In Vivo Gold Complex Catalysis within Live Mice

Application of Acrolein Imines to Organic Synthesis, Biofunctional Studies, and Clinical Practice

Emerging Technologies for Real‐Time Intraoperative Margin Assessment in Future Breast‐Conserving Surgery

Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry

Chemistry-driven translocation of glycosylated proteins in mice

The Second-Generation Click-to-Sense Probe for Intraoperative Diagnosis of Breast Cancer Tissues Based on Acrolein Targeting

Unexplored Reactivity of N -Alkyl Unsaturated Imines: A Simple Procedure for Producing Optically Active 1,3-Diamines via a Stereocontrolled Formal [4+2] and [4+2+2] Iminocycloaddition

Tetramethylrhodamine is an essential scaffold of azide probe in detecting cellular acrolein

In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6

Enantioselective synthesis of cyclic and linear diamines by imine cycloadditions

Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

Cascade Reaction in Human Live Tissue Allows Clinically Applicable Diagnosis of Breast Cancer Morphology

Facile Access to Optically Active 2,6‐Dialkyl‐1,5‐Diazacyclooctanes

Metallic radionuclide-labeled tetrameric 2,6-diisopropylphenyl azides for cancer treatment

Uncatalyzed Click Reaction between Phenyl Azides and Acrolein: 4‑Formyl-1,2,3-Triazolines as “Clicked” Markers for Visualizations of Extracellular Acrolein Released from Oxidatively Stressed Cells

A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells

In Vivo Synthetic Anticancer Approach by Resourcing Mouse Blood Albumin as a Biocompatible Artificial Metalloenzyme

Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation

Inhibition of amyloid formation of amyloid β (1–42), amylin and insulin by 1,5-diazacyclooctanes, a spermine-acrolein conjugate

Efficient synthesis of 2,6,9-triazabicyclo[3.3.1]nonanes through amine-mediated formal [4+4] reaction of unsaturated imines

Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein

A Strategy for Tumor Targeting by Higher‐Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N‐Glycan Molecules

Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses

Characterization of Natural Human Nucleotide-binding Oligomerization Domain Protein 1 (Nod1) Ligands from Bacterial Culture Supernatant for Elucidation of Immune Modulators in the Environment

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