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Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial

Clinical and experimental allergy, 2017-09, Vol.47 (9), p.1193-1203

2017

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Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement

Clinical pharmacology and therapeutics, 2015-10, Vol.98 (4), p.369-380

2015

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(Q)SAR assessments of potentially mutagenic impurities: A regulatory perspective on the utility of expert knowledge and data submission

Regulatory toxicology and pharmacology, 2015-03, Vol.71 (2), p.295-300

Powley, Mark W.

2015

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Specificity of human anti‐variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of tumour necrosis factor‐α receptor 1

Clinical and experimental immunology, 2015-11, Vol.182 (2), p.139-148

2015

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N-nitrosamine impurity risk assessment in pharmaceuticals: Utilizing In vivo mutation relative potency comparison to establish an acceptable intake for NTTP

Regulatory toxicology and pharmacology, 2024-09, Vol.152, p.105681, Article 105681

2024

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Calculating qualified non-mutagenic impurity levels: Harmonization of approaches

Regulatory toxicology and pharmacology, 2021-11, Vol.126, p.105023, Article 105023

2021

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Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol

Carcinogenesis (New York), 2005-09, Vol.26 (9), p.1573-1580

2005

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S142 Investigating patterns in 24 hours of coughing

Thorax, 2011-12, Vol.66 (Suppl 4), p.A65-A65

2011

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Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice

Toxicology (Amsterdam), 2001-12, Vol.169 (3), p.187-194

2001

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Species comparison of hepatic and pulmonary metabolism of benzene

Toxicology (Amsterdam), 1999-12, Vol.139 (3), p.207-217

1999

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Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite

Toxicology letters, 2001-12, Vol.125 (1), p.117-123

2001

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The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity

Chemico-biological interactions, 2007-03, Vol.166 (1), p.182-190

2007

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Safety Assessment of Drug Metabolites: Implications of Regulatory Guidance and Potential Application of Genetically Engineered Mouse Models that Express Human P450s

Chemical research in toxicology, 2009-02, Vol.22 (2), p.257-262

2009

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Quantile-Parameterized Distributions

Decision analysis, 2011-09, Vol.8 (3), p.206-219

2011

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Safety and pharmacodynamics of intranasal GSK 2245035, a TLR 7 agonist for allergic rhinitis: A randomized trial

Clinical and experimental allergy, 2017-09, Vol.47 (9), p.1193-1203

2017

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Timing of Carcinogenicity Studies and Predictability of Genotoxicity for Tumorigenicity in Anti-HIV Drug Development

International journal of toxicology, 2012-06, Vol.31 (3), p.211-221

2012

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1,N 2-Propanodeoxyguanosine Adducts of the 1,3-Butadiene Metabolite, Hydroxymethylvinyl Ketone

Chemical research in toxicology, 2003-11, Vol.16 (11), p.1448-1454

2003

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BENZENE METABOLISM BY THE ISOLATED PERFUSED LUNG

Inhalation toxicology, 2002-06, Vol.14 (6), p.569-584

2002

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Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes

Journal of biochemical and molecular toxicology, 2000, Vol.14 (6), p.303-309

2000

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Metabolism of styrene by human liver and lung

Journal of toxicology and environmental health, 2000-04, Vol.59 (8), p.591-595

2000

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Today's DBMSs: how autonomic are they

14th International Workshop on Database and Expert Systems Applications, 2003. Proceedings, 2003, p.651-655

2003

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Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of tumour necrosis factor-[alpha] receptor 1

Clinical and experimental immunology, 2015-11, Vol.182 (2), p.139

2015

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Using reflection to introduce self-tuning technology into DBMSs

Proceedings. International Database Engineering and Applications Symposium, 2004. IDEAS '04, 2004, p.429-438

2004

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Autonomic buffer pool configuration in PostgreSQL

2005 IEEE International Conference on Systems, Man and Cybernetics, 2005, Vol.1, p.53-58 Vol. 1

2005

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Rapid Communication METABOLISM OF STYRENE BY HUMAN LIVER AND LUNG

Journal of Toxicology and Environmental Health, Part A, 2000-04, Vol.59 (8), p.591-595

Gary P. Carlson, Nancy A. Mantick, Mark W. Powley

2000

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Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial

Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement

(Q)SAR assessments of potentially mutagenic impurities: A regulatory perspective on the utility of expert knowledge and data submission

Specificity of human anti‐variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of tumour necrosis factor‐α receptor 1

N-nitrosamine impurity risk assessment in pharmaceuticals: Utilizing In vivo mutation relative potency comparison to establish an acceptable intake for NTTP

Calculating qualified non-mutagenic impurity levels: Harmonization of approaches

Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol

S142 Investigating patterns in 24 hours of coughing

Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice

Species comparison of hepatic and pulmonary metabolism of benzene

Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite

The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity

Safety Assessment of Drug Metabolites: Implications of Regulatory Guidance and Potential Application of Genetically Engineered Mouse Models that Express Human P450s

Quantile-Parameterized Distributions

Safety and pharmacodynamics of intranasal GSK 2245035, a TLR 7 agonist for allergic rhinitis: A randomized trial

Timing of Carcinogenicity Studies and Predictability of Genotoxicity for Tumorigenicity in Anti-HIV Drug Development

1,N 2-Propanodeoxyguanosine Adducts of the 1,3-Butadiene Metabolite, Hydroxymethylvinyl Ketone

BENZENE METABOLISM BY THE ISOLATED PERFUSED LUNG

Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes

Metabolism of styrene by human liver and lung

Today's DBMSs: how autonomic are they

Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of tumour necrosis factor-[alpha] receptor 1

Using reflection to introduce self-tuning technology into DBMSs

Autonomic buffer pool configuration in PostgreSQL

Rapid Communication METABOLISM OF STYRENE BY HUMAN LIVER AND LUNG

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