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The promise of patient-derived xenografts: the best laid plans of mice and men

Clinical cancer research, 2012-10, Vol.18 (19), p.5160-5162

2012

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Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling

Antioxidants & redox signaling, 2017-02, Vol.26 (6), p.262-273

2017

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Thioredoxin signaling as a target for cancer therapy

Current opinion in pharmacology, 2007-08, Vol.7 (4), p.392-397

2007

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Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease

Biomedicine & pharmacotherapy, 2023-09, Vol.165, p.115024-115024, Article 115024

2023

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Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

Molecular cancer therapeutics, 2009-01, Vol.8 (1), p.1-9

2009

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Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

Molecular and Cellular Biology, 2008-12, Vol.28 (23), p.7081-7095

2008

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Modeling of Patient-Derived Xenografts in Colorectal Cancer

Molecular cancer therapeutics, 2017-07, Vol.16 (7), p.1435-1442

2017

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ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

Nature communications, 2016-05, Vol.7 (1), p.11551-15, Article 11551

2016

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Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

JNCI : Journal of the National Cancer Institute, 2012-02, Vol.104 (3), p.228-239

2012

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Hypoxia Triggers Hedgehog-Mediated Tumor―Stromal Interactions in Pancreatic Cancer

Cancer research (Chicago, Ill.), 2013-06, Vol.73 (11), p.3235-3247

2013

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Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Cancer research (Chicago, Ill.), 2009-01, Vol.69 (1), p.143-150

2009

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Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α

Molecular cancer therapeutics, 2008-01, Vol.7 (1), p.90-100

2008

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Passing the baton: the HIF switch

Trends in biochemical sciences (Amsterdam. Regular ed.), 2012-09, Vol.37 (9), p.364-372

2012

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The role of the redox protein thioredoxin in cell growth and cancer

Free radical biology & medicine, 2000-08, Vol.29 (3), p.312-322

2000

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An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors

Cancer research (Chicago, Ill.), 2019-06, Vol.79 (12), p.3100-3111

2019

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Properties and biological activities of thioredoxins

Annual review of pharmacology and toxicology, 2001-01, Vol.41 (1), p.261-295

2001

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Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma

Cancer research (Chicago, Ill.), 2015-01, Vol.75 (2), p.316-329

2015

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The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice

Molecular and Cellular Biology, 2003-02, Vol.23 (3), p.916-922

2003

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The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression

Molecular cancer therapeutics, 2014-12, Vol.13 (12), p.3074-3085

2014

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Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

Archives of biochemistry and biophysics, 2004-09, Vol.429 (2), p.123-133

2004

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Inhibitors of phosphatidylinositol-3-kinase in cancer therapy

Molecular aspects of medicine, 2010-04, Vol.31 (2), p.135-144

2010

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Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

Molecular cancer therapeutics, 2004-07, Vol.3 (7), p.763-772

2004

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The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

Molecular cancer therapeutics, 2007-09, Vol.6 (9), p.2505-2514

2007

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Redox Potential of Human Thioredoxin 1 and Identification of a Second Dithiol/Disulfide Motif

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33408-33415

2003

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Stability of Phosphoprotein as a Biological Marker of Tumor Signaling

Clinical cancer research, 2005-06, Vol.11 (12), p.4338-4340

2005

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The promise of patient-derived xenografts: the best laid plans of mice and men

Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling

Thioredoxin signaling as a target for cancer therapy

Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

Modeling of Patient-Derived Xenografts in Colorectal Cancer

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

Hypoxia Triggers Hedgehog-Mediated Tumor―Stromal Interactions in Pancreatic Cancer

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α

Passing the baton: the HIF switch

The role of the redox protein thioredoxin in cell growth and cancer

An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors

Properties and biological activities of thioredoxins

Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma

The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice

The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression

Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

Inhibitors of phosphatidylinositol-3-kinase in cancer therapy

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

Redox Potential of Human Thioredoxin 1 and Identification of a Second Dithiol/Disulfide Motif

Stability of Phosphoprotein as a Biological Marker of Tumor Signaling

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