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Tipping the balance: intricate roles of the complement system in disease and therapy

Seminars in immunopathology, 2021-12, Vol.43 (6), p.757-771

2021

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Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Frontiers in immunology, 2018-07, Vol.9, p.1607-1607

2018

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Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Frontiers in immunology, 2023-09, Vol.14, p.1226832-1226832

2023

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Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

PloS one, 2016-03, Vol.11 (3), p.e0152164-e0152164

2016

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Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

Frontiers in immunology, 2017-10, Vol.8, p.1328-1328

2017

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Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis

Frontiers in immunology, 2022-05, Vol.13, p.876776-876776

2022

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High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3B

Frontiers in immunology, 2018-04, Vol.9, p.848-848

2018

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Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Journal of neuroinflammation, 2019-12, Vol.16 (1), p.279-279, Article 279

2019

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Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

Frontiers in immunology, 2016-11, Vol.7, p.542-542

2016

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Developments in anti-complement therapy; from disease to clinical trial

Molecular immunology, 2018-10, Vol.102, p.89-119

2018

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Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4

Frontiers in immunology, 2018-04, Vol.9, p.729-729

2018

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Complement & disease: out of the shadow into the spotlight

Seminars in immunopathology, 2021-12, Vol.43 (6), p.755-756

2021

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Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease

British journal of pharmacology, 2021-07, Vol.178 (14), p.2802-2822

2021

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The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Clinical & translational immunology, 2023, Vol.12 (1), p.e1436-n/a

2023

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Complement-regulatory biomaterial coatings: Activity and selectivity profile of the factor H-binding peptide 5C6

Acta biomaterialia, 2023-01, Vol.155, p.123-138

2023

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Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs

Blood, 2024-01, Vol.143 (1), p.79

2024

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Evaluating the clinical utility of measuring levels of factor H and the related proteins

Molecular immunology, 2022-11, Vol.151, p.166-182

2022

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Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

American journal of human genetics, 2022-09, Vol.109 (9), p.1680-1691

2022

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TFPI inhibits lectin pathway of complement activation by direct interaction with MASP‐2

European journal of immunology, 2015-02, Vol.45 (2), p.544-550

2015

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Corrigendum: High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3B

Frontiers in immunology, 2020-01, Vol.10

2020

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Improved complement regulation on host surfaces by a potentiating antibody against complement factor H as a new therapeutic strategy

Immunobiology (1979), 2016-10, Vol.221 (10), p.1156-1156

2016

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Factor H-related protein 3 (FHR-3) inhibits factor H binding to pentraxins and malondialdehyde epitopes, and activates the alternative pathway via C3b binding

Immunobiology (1979), 2016-10, Vol.221 (10), p.1177-1177

2016

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Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera

Blood advances, 2019-02, Vol.3 (4), p.621-632

2019

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No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice

Vascular biology, 2022-11, Vol.4 (1), p.40-49

2022

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157 From parasite to therapeutic: Expression, functional characterization, and therapeutic potential of the leech-derived complement inhibitor gigastasin

Immunobiology (1979), 2023-09, Vol.228 (5), p.152607, Article 152607

2023

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Tipping the balance: intricate roles of the complement system in disease and therapy

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis

High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3B

Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

Developments in anti-complement therapy; from disease to clinical trial

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4

Complement & disease: out of the shadow into the spotlight

Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Complement-regulatory biomaterial coatings: Activity and selectivity profile of the factor H-binding peptide 5C6

Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs

Evaluating the clinical utility of measuring levels of factor H and the related proteins

Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

TFPI inhibits lectin pathway of complement activation by direct interaction with MASP‐2

Corrigendum: High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3B

Improved complement regulation on host surfaces by a potentiating antibody against complement factor H as a new therapeutic strategy

Factor H-related protein 3 (FHR-3) inhibits factor H binding to pentraxins and malondialdehyde epitopes, and activates the alternative pathway via C3b binding

Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera

No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice

157 From parasite to therapeutic: Expression, functional characterization, and therapeutic potential of the leech-derived complement inhibitor gigastasin

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