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Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

Journal of natural products (Washington, D.C.), 2008-10, Vol.71 (10), p.1732-1737

2008

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3684-3687

2005

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Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

Journal of the American Chemical Society, 2006-04, Vol.128 (15), p.5136-5141

2006

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Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Organic letters, 2007-06, Vol.9 (12), p.2289-2292

2007

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Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6711-6724

2008

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Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Journal of natural products (Washington, D.C.), 2004-08, Vol.67 (8), p.1400-1402

2004

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Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Journal of natural products (Washington, D.C.), 2007-09, Vol.70 (9), p.1454-1457

2007

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Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

Applied microbiology and biotechnology, 2007-07, Vol.75 (5), p.999-1005

2007

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Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.240-243

2005

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Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Journal of natural products (Washington, D.C.), 2005-05, Vol.68 (5), p.780-783

2005

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Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Journal of natural products (Washington, D.C.), 2007-02, Vol.70 (2), p.269-276

2007

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Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

Journal of antibiotics, 2007-01, Vol.60 (1), p.13-19

2007

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A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

Journal of pharmaceutical sciences, 2007-08, Vol.96 (8), p.2037-2047

2007

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6-Bromotryptamine Derivatives from the Gulf of California Tunicate Didemnum candidum

Journal of natural products (Washington, D.C.), 1991-03, Vol.54 (2), p.564-569

1991

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The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins

Nature structural & molecular biology, 1995-09, Vol.2 (9), p.790-796

1995

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Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Planta medica, 2012-01, Vol.78 (2), p.131-134

2012

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Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.729

2001

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New nitrogenous sesquiterpenes from two Philippine nudibranchs, Phyllidia pustulosa and P. varicosa, and from a Palauan sponge, Halichondria cf. lendenfeldi

Journal of organic chemistry, 1991-05, Vol.56 (11), p.3747-3750

1991

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Chemical mechanism of inactivation of bee venom phospholipase A2 by the marine natural products manoalide, luffariellolide, and scalaradial

Journal of the American Chemical Society, 1992-06, Vol.114 (13), p.5093-5100

1992

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Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces n odosus

Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.240-243

2005

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Stereoselective enzymatic reduction of keto-salinosporamide to (−)-salinosporamide A (NPI-0052)

Tetrahedron letters, 2007-04, Vol.48 (14), p.2537-2540

2007

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NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse

Journal of pharmaceutical and biomedical analysis, 2001-10, Vol.26 (3), p.463-476

2001

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Luffalactone and (4E,6E)-dehydromanoalide from the sponge Luffariella variabilis

Journal of organic chemistry, 1992-05, Vol.57 (10), p.2965-2967

1992

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Didemnaketals A and B, HIV-1 protease inhibitors from the ascidian Didemnum sp

Journal of the American Chemical Society, 1991-07, Vol.113 (16), p.6321-6322

1991

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A mechanistic and kinetic study of the p-lactone hydrolysis of salinosporamide A (NPI-0052), a novel proteasome inhibitor

Journal of pharmaceutical sciences, 2007, Vol.96 (8), p.2037-2047

2007

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Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

6-Bromotryptamine Derivatives from the Gulf of California Tunicate Didemnum candidum

The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins

Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease

New nitrogenous sesquiterpenes from two Philippine nudibranchs, Phyllidia pustulosa and P. varicosa, and from a Palauan sponge, Halichondria cf. lendenfeldi

Chemical mechanism of inactivation of bee venom phospholipase A2 by the marine natural products manoalide, luffariellolide, and scalaradial

Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces n odosus

Stereoselective enzymatic reduction of keto-salinosporamide to (−)-salinosporamide A (NPI-0052)

NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse

Luffalactone and (4E,6E)-dehydromanoalide from the sponge Luffariella variabilis

Didemnaketals A and B, HIV-1 protease inhibitors from the ascidian Didemnum sp

A mechanistic and kinetic study of the p-lactone hydrolysis of salinosporamide A (NPI-0052), a novel proteasome inhibitor

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