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Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

Journal of the American Chemical Society, 2006-04, Vol.128 (15), p.5136-5141

2006

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The odyssey of marine pharmaceuticals: a current pipeline perspective

Trends in pharmacological sciences (Regular ed.), 2010-06, Vol.31 (6), p.255-265

2010

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Proteasome structure, function, and lessons learned from beta-lactone inhibitors

Current topics in medicinal chemistry, 2011-12, Vol.11 (23), p.2850

2011

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2175-2180

2009

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Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

Journal of natural products (Washington, D.C.), 2008-10, Vol.71 (10), p.1732-1737

2008

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3684-3687

2005

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Concise Formal Synthesis of (−)-Salinosporamide A (Marizomib) Using a Regio- and Stereoselective Epoxidation and Reductive Oxirane Ring-Opening Strategy

Journal of organic chemistry, 2010-06, Vol.75 (11), p.3882-3885

2010

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Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Organic letters, 2007-06, Vol.9 (12), p.2289-2292

2007

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Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI‐0052 (marizomib) in a human plasmacytoma xenograft murine model

British journal of haematology, 2010-05, Vol.149 (4), p.550-559

2010

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Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides

Marine Drugs, 2010-03, Vol.8 (4), p.835-880

2010

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Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Journal of natural products (Washington, D.C.), 2007-09, Vol.70 (9), p.1454-1457

2007

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Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6711-6724

2008

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Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.240-243

2005

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Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition

Journal of medicinal chemistry, 2009-09, Vol.52 (17), p.5420-5428

2009

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Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Journal of natural products (Washington, D.C.), 2005-05, Vol.68 (5), p.780-783

2005

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Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Journal of natural products (Washington, D.C.), 2007-02, Vol.70 (2), p.269-276

2007

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Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Planta medica, 2012-01, Vol.78 (2), p.131

2012

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Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Journal of natural products (Washington, D.C.), 2004-08, Vol.67 (8), p.1400-1402

2004

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Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

Applied microbiology and biotechnology, 2007-07, Vol.75 (5), p.999-1005

2007

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Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

Journal of antibiotics, 2007-01, Vol.60 (1), p.13-19

2007

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Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.479

2011

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A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

Journal of pharmaceutical sciences, 2007-08, Vol.96 (8), p.2037-2047

2007

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Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

Chemico-biological interactions, 2011-10, Vol.194 (1), p.58-68

2011

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6-Bromotryptamine Derivatives from the Gulf of California Tunicate Didemnum candidum

Journal of natural products (Washington, D.C.), 1991-03, Vol.54 (2), p.564-569

1991

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Antiprotealide Is a Natural Product

Journal of natural products (Washington, D.C.), 2009-02, Vol.72 (2), p.295-297

2009

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Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

The odyssey of marine pharmaceuticals: a current pipeline perspective

Proteasome structure, function, and lessons learned from beta-lactone inhibitors

Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Concise Formal Synthesis of (−)-Salinosporamide A (Marizomib) Using a Regio- and Stereoselective Epoxidation and Reductive Oxirane Ring-Opening Strategy

Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI‐0052 (marizomib) in a human plasmacytoma xenograft murine model

Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides

Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition

Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

6-Bromotryptamine Derivatives from the Gulf of California Tunicate Didemnum candidum

Antiprotealide Is a Natural Product

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