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Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

Journal of the American Chemical Society, 2006-04, Vol.128 (15), p.5136-5141

2006

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Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

Journal of natural products (Washington, D.C.), 2008-10, Vol.71 (10), p.1732-1737

2008

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The odyssey of marine pharmaceuticals: a current pipeline perspective

Trends in pharmacological sciences (Regular ed.), 2010-06, Vol.31 (6), p.255-265

2010

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Proteasome structure, function, and lessons learned from beta-lactone inhibitors

Current topics in medicinal chemistry, 2011-12, Vol.11 (23), p.2850-2878

2011

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2175-2180

2009

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3684-3687

2005

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Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Organic letters, 2007-06, Vol.9 (12), p.2289-2292

2007

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Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Planta medica, 2012-01, Vol.78 (2), p.131-134

2012

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Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI‐0052 (marizomib) in a human plasmacytoma xenograft murine model

British journal of haematology, 2010-05, Vol.149 (4), p.550-559

2010

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Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Journal of natural products (Washington, D.C.), 2007-09, Vol.70 (9), p.1454-1457

2007

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Concise Formal Synthesis of (−)-Salinosporamide A (Marizomib) Using a Regio- and Stereoselective Epoxidation and Reductive Oxirane Ring-Opening Strategy

Journal of organic chemistry, 2010-06, Vol.75 (11), p.3882-3885

2010

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Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6711-6724

2008

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Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Journal of natural products (Washington, D.C.), 2005-02, Vol.68 (2), p.240-243

2005

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Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides

Marine Drugs, 2010-03, Vol.8 (4), p.835-880

2010

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Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Journal of natural products (Washington, D.C.), 2005-05, Vol.68 (5), p.780-783

2005

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Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Journal of natural products (Washington, D.C.), 2007-02, Vol.70 (2), p.269-276

2007

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Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Journal of natural products (Washington, D.C.), 2004-08, Vol.67 (8), p.1400-1402

2004

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Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition

Journal of medicinal chemistry, 2009-09, Vol.52 (17), p.5420-5428

2009

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Synthesis and structure–activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents

Bioorganic & medicinal chemistry, 2012-07, Vol.20 (14), p.4279-4289

2012

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Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

Applied microbiology and biotechnology, 2007-07, Vol.75 (5), p.999-1005

2007

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A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

Journal of pharmaceutical sciences, 2007-08, Vol.96 (8), p.2037-2047

2007

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Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.479-486

2011

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Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

Journal of antibiotics, 2007-01, Vol.60 (1), p.13-19

2007

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Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

Chemico-biological interactions, 2011-10, Vol.194 (1), p.58-68

2011

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Introduction to papers on mycoplasmology presented at a Parenteral Drug Association mycoplasma workshop

Biologicals, 2010-03, Vol.38 (2), p.181-182

Potts, Barbara J.

2010

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Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of β-Lactone Ring Opening and a Mechanism for Irreversible Binding

Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

The odyssey of marine pharmaceuticals: a current pipeline perspective

Proteasome structure, function, and lessons learned from beta-lactone inhibitors

Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI‐0052 (marizomib) in a human plasmacytoma xenograft murine model

Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment

Concise Formal Synthesis of (−)-Salinosporamide A (Marizomib) Using a Regio- and Stereoselective Epoxidation and Reductive Oxirane Ring-Opening Strategy

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus

Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides

Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition

Synthesis and structure–activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents

Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins

A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica

Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

Introduction to papers on mycoplasmology presented at a Parenteral Drug Association mycoplasma workshop

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