UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 326

Sortiert nach

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

Cancer cell, 2013-12, Vol.24 (6), p.710-724

2013

Volltextzugriff (PDF)

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

Drug discovery today, 2013-01, Vol.18 (1-2), p.43-49

2013

Volltextzugriff (PDF)

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

RNA (Cambridge), 2018-08, Vol.24 (8), p.1056-1066

2018

Volltextzugriff (PDF)

Targeting the DNA Repair Pathway in Ewing Sarcoma

Cell reports (Cambridge), 2014-11, Vol.9 (3), p.829-840

2014

Volltextzugriff (PDF)

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11

Biochemical pharmacology, 2011-01, Vol.81 (1), p.24-31

2011

Volltextzugriff (PDF)

Modulation of Esterified Drug Metabolism by Tanshinones from Salvia miltiorrhiza (“Danshen”)

Journal of natural products (Washington, D.C.), 2013-01, Vol.76 (1), p.36-44

2013

Volltextzugriff (PDF)

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

Bioorganic & medicinal chemistry, 2018-01, Vol.26 (1), p.25-36

2018

Volltextzugriff (PDF)

Development of a tumor-selective approach to treat metastatic cancer

PloS one, 2006-12, Vol.1 (1), p.e23

2006

Volltextzugriff (PDF)

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

Chemico-biological interactions, 2013-03, Vol.203 (1), p.226-230

2013

Volltextzugriff (PDF)

Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases

Biochemical pharmacology, 2006-02, Vol.71 (5), p.657-669

2006

Volltextzugriff (PDF)

Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597

Biochemical pharmacology, 2012-11, Vol.84 (9), p.1215-1222

2012

Volltextzugriff (PDF)

Multisite Promiscuity in the Processing of Endogenous Substrates by Human Carboxylesterase 1

Journal of molecular biology, 2006-10, Vol.363 (1), p.201-214

2006

Volltextzugriff (PDF)

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

Nature structural & molecular biology, 2003-05, Vol.10 (5), p.349-356

2003

Volltextzugriff (PDF)

Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma

Cancer research (Chicago, Ill.), 2007, Vol.67 (1), p.22-25

2007

Volltextzugriff (PDF)

Neural Stem Cell‐Mediated Delivery of Irinotecan‐Activating Carboxylesterases to Glioma: Implications for Clinical Use

Stem cells translational medicine, 2013-12, Vol.2 (12), p.983-992

2013

Volltextzugriff (PDF)

Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin

Molecular pharmacology, 2010-04, Vol.77 (4), p.508-516

2010

Volltextzugriff (PDF)

Carboxylesterases: General detoxifying enzymes

Chemico-biological interactions, 2016-11, Vol.259 (Pt B), p.327-331

2016

Volltextzugriff (PDF)

Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) Toxicity

Journal of medicinal chemistry, 2009-06, Vol.52 (12), p.3742-3752

2009

Volltextzugriff (PDF)

Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats

Drug metabolism and disposition, 2006-10, Vol.34 (10), p.1764

2006

Volltextzugriff (PDF)

Selective Inhibition of Carboxylesterases by Isatins, Indole-2,3-diones

Journal of medicinal chemistry, 2007-04, Vol.50 (8), p.1876-1885

2007

Volltextzugriff (PDF)

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance

The AAPS journal, 2016-11, Vol.18 (6), p.1391-1405

2016

Volltextzugriff (PDF)

Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids

Biochimica et biophysica acta, 2010-01, Vol.1801 (1), p.31-41

2010

Volltextzugriff (PDF)

Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones

Bioorganic & medicinal chemistry, 2011-08, Vol.19 (15), p.4635-4643

2011

Volltextzugriff (PDF)

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure–activity relationship analysis

Bioorganic & medicinal chemistry, 2009-01, Vol.17 (1), p.149-164

2009

Volltextzugriff (PDF)

Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

Nature medicine, 2019-04, Vol.25 (4), p.597-602

2019

Volltextzugriff (PDF)

1 – 25 von 326

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(276)
Mit Volltextzugriff
(289)

Publikationsform

1 weiteren anzeigen...

Weniger anzeigen...

Sprache

Erscheinungsjahr

n.n

Thema

Science & Technology
(232)
Life Sciences & Biomedicine
(206)
Humans
(177)
Animals
(96)
Biological And Medical Sciences
(75)
Medical Sciences
(59)
Female
(56)
Pharmacology & Pharmacy
(52)
Male
(51)
Biochemistry & Molecular Biology
(45)
Camptothecin - Analogs & Derivatives
(40)
Carboxylic Ester Hydrolases - Metabolism
(39)
Carboxylesterase
(37)
Pharmacology. Drug Treatments
(35)
Adult
(33)
Middle Aged
(33)
Oncology
(33)
Aged
(32)
Mice
(30)
Rabbits
(28)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

Targeting the DNA Repair Pathway in Ewing Sarcoma

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11

Modulation of Esterified Drug Metabolism by Tanshinones from Salvia miltiorrhiza (“Danshen”)

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

Development of a tumor-selective approach to treat metastatic cancer

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases

Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597

Multisite Promiscuity in the Processing of Endogenous Substrates by Human Carboxylesterase 1

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma

Neural Stem Cell‐Mediated Delivery of Irinotecan‐Activating Carboxylesterases to Glioma: Implications for Clinical Use

Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin

Carboxylesterases: General detoxifying enzymes

Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) Toxicity

Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats

Selective Inhibition of Carboxylesterases by Isatins, Indole-2,3-diones

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance

Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids

Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure–activity relationship analysis

Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

Suchergebnisse filtern