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Exploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function

Frontiers in cellular neuroscience, 2021-11, Vol.15, p.768655-768655

2021

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Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay

ACS chemical biology, 2020-01, Vol.15 (1), p.290-295

2020

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Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β‑Coronaviruses

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.12860-12882

2022

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Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.101986, Article 101986

2022

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Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.2006-2017

2017

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Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

Alzheimer's & dementia : translational research & clinical interventions, 2022, Vol.8 (1), p.e12253-n/a

2022

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AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

Alzheimer's & dementia : translational research & clinical interventions, 2022, Vol.8 (1), p.e12246-n/a

2022

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Combinatorial latency reversal activity of inhibitor of apoptosis antagonists with mechanistically distinct classes of HIV latency reversal agents

Journal of Virus Eradication, 2019-12, Vol.5, p.47-48

2019

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Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

Cell chemical biology, 2020-01, Vol.27 (1), p.47-56.e15

2020

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TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

Cancer discovery, 2020-03, Vol.10 (3), p.460-475

2020

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EZH1-PRC2 Identifies a Potential Reservoir for Disease Relapse in Quiescent Cancer Cells Refractory to EZH2 Enzymatic Inhibition

Blood, 2022-11, Vol.140 (Supplement 1), p.3049-3050

2022

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PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components

ACS chemical biology, 2023-03, Vol.18 (3), p.494-507

2023

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Towards the development of a chemical probe targeting the disruption of SYK tandem SH2 domain and FCεR1γ interactions for Alzheimer’s disease

Alzheimer's & dementia, 2023-06, Vol.19 (S7), p.n/a

2023

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Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ)

Current research in chemical biology, 2023, Vol.3, p.100036, Article 100036

2023

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Amidation of Esters with Amino Alcohols Using Organobase Catalysis

Journal of organic chemistry, 2014-10, Vol.79 (19), p.9347-9354

2014

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Structure–Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.722-748

2017

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Generation of the AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery

Alzheimer's & dementia, 2021-12, Vol.17 (S9), p.n/a

2021

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Structure-guided approaches to the design of novel autotaxin inhibitors

Potjewyd, Frances

2016

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Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal

ACS infectious diseases, 2020-07, Vol.6 (7), p.1719-1733

2020

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Adding the right (or left) twist to tris-chelate complexes--coordination chemistry of chiral oxazolylphenolates with M3+ ions (M = Al or lanthanide)

Dalton transactions : an international journal of inorganic chemistry, 2014-01, Vol.43 (3), p.1434-1442

2014

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Adding the right (or left) twist to tris-chelate complexes – coordination chemistry of chiral oxazolylphenolates with M 3+ ions (M = Al or lanthanide)

Dalton transactions : an international journal of inorganic chemistry, 2014, Vol.43 (3), p.1434-1442

2014

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Adding the right (or left) twist to tris-chelate complexes - coordination chemistry of chiral oxazolylphenolates with M3+ ions (M = Al or lanthanide)Electronic supplementary information (ESI) available: Experimental details for synthesis of benzyl oxazolylphenols and naphthol, NMR spectra for selected compounds, cif files for crystallographically characterized complexes. CCDC 957726-957731. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3dt52366g

2013-12

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Adding the right (or left) twist to tris-chelate complexes - coordination chemistry of chiral oxazolylphenolates with M super(3+) ions (M = Al or lanthanide)

Dalton transactions : an international journal of inorganic chemistry, 2013-12, Vol.43 (3), p.1434-1442

2013

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ChemInform Abstract: Amidation of Esters with Amino Alcohols Using Organobase Catalysis

ChemInform, 2015-03, Vol.46 (12), p.no-no

2015

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Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

SSRN Electronic Journal

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Exploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function

Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β‑Coronaviruses

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

Combinatorial latency reversal activity of inhibitor of apoptosis antagonists with mechanistically distinct classes of HIV latency reversal agents

Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

EZH1-PRC2 Identifies a Potential Reservoir for Disease Relapse in Quiescent Cancer Cells Refractory to EZH2 Enzymatic Inhibition

PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components

Towards the development of a chemical probe targeting the disruption of SYK tandem SH2 domain and FCεR1γ interactions for Alzheimer’s disease

Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ)

Amidation of Esters with Amino Alcohols Using Organobase Catalysis

Structure–Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode

Generation of the AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery

Structure-guided approaches to the design of novel autotaxin inhibitors

Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal

Adding the right (or left) twist to tris-chelate complexes--coordination chemistry of chiral oxazolylphenolates with M3+ ions (M = Al or lanthanide)

Adding the right (or left) twist to tris-chelate complexes – coordination chemistry of chiral oxazolylphenolates with M 3+ ions (M = Al or lanthanide)

Adding the right (or left) twist to tris-chelate complexes - coordination chemistry of chiral oxazolylphenolates with M super(3+) ions (M = Al or lanthanide)

ChemInform Abstract: Amidation of Esters with Amino Alcohols Using Organobase Catalysis

Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

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