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Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

Nature communications, 2016-02, Vol.7 (1), p.10690-10690, Article 10690

2016

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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Nature communications, 2017-12, Vol.8 (1), p.2270-2270, Article 2270

2017

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ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression

Genes & development, 2017-09, Vol.31 (17), p.1770-1783

2017

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TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer

Cancer research (Chicago, Ill.), 2017-09, Vol.77 (18), p.5077-5094

2017

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SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Nature communications, 2017-01, Vol.8 (1), p.14098-13, Article 14098

2017

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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Nature communications, 2024-07, Vol.15 (1), p.6125-20, Article 6125

2024

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HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress

Cancer research (Chicago, Ill.), 2018-11, Vol.78 (21), p.6196-6208

2018

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Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Nature chemical biology, 2016-04, Vol.12 (4), p.218-225

2016

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Precursor-directed generation of amidine containing ammosamide analogs: ammosamides E–P

Chemical science (Cambridge), 2013-01, Vol.4 (1), p.482-488

2013

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A highly-sensitive high throughput assay for dynamin's basal GTPase activity

PloS one, 2017-09, Vol.12 (9), p.e0185639-e0185639

2017

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Small molecule glucagon release inhibitors with activity in human islets

Frontiers in endocrinology (Lausanne), 2023-04, Vol.14, p.1114799-1114799

2023

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Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia

JCI insight, 2020-01, Vol.5 (1)

2020

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Enhanced HTS Hit Selection via a Local Hit Rate Analysis

Journal of Chemical Information and Modeling, 2009-10, Vol.49 (10), p.2202-2210

2009

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Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition

JCI insight, 2022-09, Vol.7 (17)

2022

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

Nature (London), 2016-10, Vol.538 (7623), p.114-117

2016

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Chromomycin SA analogs from a marine-derived Streptomyces sp

Bioorganic & medicinal chemistry, 2011-09, Vol.19 (17), p.5183-5189

2011

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A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells

Proceedings of the National Academy of Sciences - PNAS, 2024-02, Vol.121 (7), p.e2318024121-e2318024121

2024

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1,25-Dihydroxyvitamin D 3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor

The Journal of steroid biochemistry and molecular biology, 2019-01, Vol.185, p.17

2019

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Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines

Nature biotechnology, 2016-01, Vol.34 (1), p.70-77

2016

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High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl‑2 Binding

ACS chemical biology, 2018-08, Vol.13 (8), p.2247-2260

2018

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Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5199-5221

2018

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Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity

Chemical science (Cambridge), 2021-08, Vol.12 (3), p.1388-1394

2021

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Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia

The Journal of biological chemistry, 2011-05, Vol.286 (18), p.16101-16108

2011

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Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function

Endocrinology (Philadelphia), 2022-07, Vol.163 (7), p.1

2022

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Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression

TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Precursor-directed generation of amidine containing ammosamide analogs: ammosamides E–P

A highly-sensitive high throughput assay for dynamin's basal GTPase activity

Small molecule glucagon release inhibitors with activity in human islets

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia

Enhanced HTS Hit Selection via a Local Hit Rate Analysis

Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

Chromomycin SA analogs from a marine-derived Streptomyces sp

A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells

1,25-Dihydroxyvitamin D 3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor

Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl‑2 Binding

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia

Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function

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