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Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

Biochemical pharmacology, 2011-10, Vol.82 (8), p.891-903

2011

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Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP

Journal of neurochemistry, 2006-07, Vol.98 (2), p.601-615

2006

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Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

The Journal of pharmacology and experimental therapeutics, 2005-11, Vol.315 (2), p.711

2005

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G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Current topics in medicinal chemistry, 2011-08, Vol.11 (15), p.1902

2011

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Influence of the 5-HT6 Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT6 Receptor Antagonist

Journal of medicinal chemistry, 2003-03, Vol.46 (7), p.1273-1276

2003

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Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

Molecular pharmacology, 2003-10, Vol.64 (4), p.823-832

2003

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An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application

Journal of chemical information and modeling, 2005-09, Vol.45 (5), p.1324-1336

2005

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Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1892-1897

2006

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Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors

European journal of pharmacology, 2006-01, Vol.529 (1), p.95-104

2006

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Antagonists of the human adenosine A2A receptor. Part 1 Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

Bioorganic & medicinal chemistry letters, 2008-05, Vol.18 (9), p.2916-2919

2008

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3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2779-2782

2000

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Glutamate and Parkinson's disease

Molecular neurobiology, 1996-02, Vol.12 (1), p.73-94

1996

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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5746-5752

2009

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3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl-4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity

Journal of medicinal chemistry, 2000-11, Vol.43 (24), p.4724-4724

2000

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GluR1 Glutamate Receptor Subunit Is Regulated Differentially in the Primate Basal Ganglia Following Nigrostriatal Dopamine Denervation

Journal of neurochemistry, 2000-03, Vol.74 (3), p.1166-1174

2000

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Regional Variations in the Pharmacology of NMDA Receptor Channel Blockers: Implications for Therapeutic Potential

Journal of neurochemistry, 1995-02, Vol.64 (2), p.614-623

1995

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Inhibition of Succinate Dehydrogenase by Malonic Acid Produces an “Excitotoxic” Lesion in Rat Striatum

Journal of neurochemistry, 1993-09, Vol.61 (3), p.1151-1154

1993

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NMDA and AMPA Receptors in Transgenic Mice Expressing Human β‐Amyloid Protein

Journal of neurochemistry, 1993-12, Vol.61 (6), p.2286-2289

1993

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Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells

Biochemical pharmacology, 2001-08, Vol.62 (4), p.431-438

2001

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Characterisation of agonist binding on human 5-HT2C receptor isoforms

European journal of pharmacology, 2001-05, Vol.419 (2-3), p.107-112

2001

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Influence of the 5-HT 6 Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT 6 Receptor Antagonist

Journal of medicinal chemistry, 2003-03, Vol.46 (7), p.1273-1276

2003

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Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA sub(A) alpha 5 inverse agonist series

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5746-5752

2009

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Antagonists of the human adenosine A sub(2A) receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

Bioorganic & medicinal chemistry, 2008-05, Vol.18 (9), p.2916-2919

2008

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Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5746

2009

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Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Influence of the 5-HT6 Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT6 Receptor Antagonist

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors

Antagonists of the human adenosine A2A receptor. Part 1 Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series

3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity

Glutamate and Parkinson's disease

Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl-4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity

GluR1 Glutamate Receptor Subunit Is Regulated Differentially in the Primate Basal Ganglia Following Nigrostriatal Dopamine Denervation

Regional Variations in the Pharmacology of NMDA Receptor Channel Blockers: Implications for Therapeutic Potential

Inhibition of Succinate Dehydrogenase by Malonic Acid Produces an “Excitotoxic” Lesion in Rat Striatum

NMDA and AMPA Receptors in Transgenic Mice Expressing Human β‐Amyloid Protein

Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells

Characterisation of agonist binding on human 5-HT2C receptor isoforms

Influence of the 5-HT 6 Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT 6 Receptor Antagonist

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA sub(A) alpha 5 inverse agonist series

Antagonists of the human adenosine A sub(2A) receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series

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