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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

Chemical reviews, 2016-09, Vol.116 (17), p.9683-9747

2016

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Dearomatization Strategies in the Synthesis of Complex Natural Products

Angewandte Chemie International Edition, 2011-04, Vol.50 (18), p.4068-4093

International ed. in English, 2011

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Total Syntheses of Secalonic Acids A and D

Angewandte Chemie International Edition, 2014-03, Vol.53 (12), p.3107-3110

2014

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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Nature communications, 2019-01, Vol.10 (1), p.402-402, Article 402

2019

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Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids

Angewandte Chemie International Edition, 2020-12, Vol.59 (52), p.23772-23781

International ed. in English, 2020

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Asymmetric, Stereodivergent Synthesis of (−)-Clusianone Utilizing a Biomimetic Cationic Cyclization

Angewandte Chemie International Edition, 2014-07, Vol.53 (30), p.7832-7837

International ed. in English, 2014

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Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

Natural product reports, 2013-01, Vol.3 (3), p.382-391

2013

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Nature (London), 2014-09, Vol.513 (7516), p.65-70

2014

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Triple-Dearomative Photocycloaddition: A Strategy to Construct Caged Molecular Frameworks

Journal of the American Chemical Society, 2024-05, Vol.146 (19), p.13445-13454

2024

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Unified, Asymmetric Total Synthesis of the Asnovolins and Related Spiromeroterpenoids: A Fragment Coupling Approach

Journal of the American Chemical Society, 2022-07, Vol.144 (28), p.12970-12978

2022

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Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt

Journal of the American Chemical Society, 2024-02, Vol.146 (7), p.4892-4902

2024

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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Nature communications, 2022-10, Vol.13 (1), p.6513-6513, Article 6513

2022

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Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization

Angewandte Chemie International Edition, 2019-11, Vol.58 (45), p.16141-16146

International ed. in English, 2019

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How proteins bind macrocycles

Nature chemical biology, 2014-09, Vol.10 (9), p.723-731

2014

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Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (−)-Nemorosone and (−)-6-epi-Garcimultiflorone A

Journal of the American Chemical Society, 2019-07, Vol.141 (28), p.11315-11321

2019

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CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

Cell reports (Cambridge), 2016-06, Vol.15 (11), p.2340-2347

2016

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Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis

ACS catalysis, 2012-01, Vol.2 (1), p.65-70

2012

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Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

Cell chemical biology, 2019-11, Vol.26 (11), p.1586-1593.e3

2019

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An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

Nature communications, 2020-12, Vol.11 (1), p.6429-17, Article 6429

2020

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Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of DMOA-Derived Spiromeroterpenoids

Journal of organic chemistry, 2024-09, Vol.89 (17), p.11891-11908

2024

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Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Cell reports (Cambridge), 2020-02, Vol.30 (8), p.2481-2488.e5

2020

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Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate

Angewandte Chemie International Edition, 2019-03, Vol.58 (13), p.4291-4296

International ed. in English, 2019

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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

PloS one, 2009-04, Vol.4 (4), p.e5223-e5223

2009

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Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6143), p.250-250

2013

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Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition

Chemistry : a European journal, 2016-08, Vol.22 (34), p.12006-12010

2016

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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

Dearomatization Strategies in the Synthesis of Complex Natural Products

Total Syntheses of Secalonic Acids A and D

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids

Asymmetric, Stereodivergent Synthesis of (−)-Clusianone Utilizing a Biomimetic Cationic Cyclization

Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Triple-Dearomative Photocycloaddition: A Strategy to Construct Caged Molecular Frameworks

Unified, Asymmetric Total Synthesis of the Asnovolins and Related Spiromeroterpenoids: A Fragment Coupling Approach

Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization

How proteins bind macrocycles

Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (−)-Nemorosone and (−)-6-epi-Garcimultiflorone A

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of DMOA-Derived Spiromeroterpenoids

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition

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