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Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstituted Guanosines and Structurally Related Compounds

Journal of medicinal chemistry, 1994-10, Vol.37 (21), p.3561-3578

1994

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Immunopharmacology: a new frontier

Canadian journal of physiology and pharmacology, 1989-06, Vol.67 (6), p.537-545

Pope, B L

1989

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Suppressor cells in the spleens of tumor-bearing mice: enrichment by centrifugation on hypaque-ficoll and characterization of the suppressor population

The Journal of immunology (1950), 1976-05, Vol.116 (5), p.1342-1346

1976

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Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells

The Journal of pharmacology and experimental therapeutics, 1999-06, Vol.289 (3), p.1465

1999

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Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac‐1 and E‐selectin expression

European journal of immunology, 1996-01, Vol.26 (1), p.120-129

1996

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7-Allyl-8-oxoguanosine (loxoribine) inhibits the metastasis of B16 melanoma cells and has adjuvant activity in mice immunized with a B16 tumor vaccine

Cancer Immunology Immunotherapy, 1994-03, Vol.38 (2), p.83-91

1994

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Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2

The Journal of immunology (1950), 1993-09, Vol.151 (6), p.3007-3017

1993

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Tepoxalin, a novel immunomodulatory compound, synergizes with CsA in suppression of graft-versus-host reaction and allogeneic skin graft rejection

Transplantation, 1995-08, Vol.60 (4), p.362-367

1995

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Enhancement of immunostimulatory activity by dual substitution of C8-substituted guanine ribonucleosides: correlation with increased cytokine secretion

Journal of immunotherapy (1997), 1995-02, Vol.17 (2), p.98-108

1995

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A Leukocyte Lipid Up-Regulates the Avidity of Lymphocyte Function-Associated Antigen-1

Biochemical and biophysical research communications, 1994-02, Vol.199 (1), p.319-326

1994

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The Immunostimulatory Compound 7-Allyl-8-Oxoguanosine (Loxoribine) Induces a Distinct Subset of Murine Cytokines

Cellular immunology, 1995-05, Vol.162 (2), p.333-339

1995

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Secretion of a suppressor cell-inducing factor by an interleukin 3-dependent cell Line with natural cytotoxic activity. II. Range, potency, and kinetics of suppressive activity

Immunobiology (1979), 1987, Vol.174 (1), p.107-118

Pope, Barbara L.

1987

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The effect of indomethacin on the activation and effector function of suppressor cells from tumor-bearing mice

Cancer Immunology Immunotherapy, 1985-04, Vol.19 (2), p.101-108

POPE, B. L

1985

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In Vivo Activation of Natural Killer Cells and Priming of IL-2 Responsive Cytolytic Cells by Loxoribine (7-Allyl-8-oxoguanosine)

Cellular immunology, 1993-04, Vol.147 (2), p.302-312

1993

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Murine Strain Variation in the Natural Killer Cell and Proliferative Responses to the Immunostimulatory Compound 7-Allyl-8-oxoguanosine: Role of Cytokines

Cellular immunology, 1994-12, Vol.159 (2), p.194-210

1994

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Activation of suppressor T cells by low-molecular-weight factors secreted by spleen cells from tumor-bearing mice

Cellular immunology, 1985-01, Vol.93 (2), p.364-374

Pope, Barbara L.

1985

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Enhancement of tumor growth by suppressor factors derived from a natural suppressor/cytotoxic cell line

Transplantation, 1988-05, Vol.45 (5), p.998-1000

1988

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Secretion of a suppressor cell inducing factor by an interleukin 3-dependent cell line with natural cytotoxic activity

Cellular immunology, 1988-10, Vol.116 (1), p.1-11

1988

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Secretion of a suppressor cell inducing factor by an interieukin-3 dependent cell line with natural cytotoxic activity

Cellular immunology, 1986, Vol.100 (1), p.97-111

1986

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Induction of suppression by a murine nonspecific suppressor-inducer cell line (M1-A5)

Cellular immunology, 1985-11, Vol.96 (1), p.199-209

1985

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The involvement of protein kinase C, calcium, and 5-lipoxygenase in the production of tumor necrosis factor by a cloned interleukin-3 dependent cell line with natural cytotoxic activity

International journal of immunopharmacology, 1991, Vol.13 (2), p.175-184

1991

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Requirement for prostaglandin E 1 (PGE 1) for the secretion of suppressor cell inducer factors by spleen cells of tumor-bearing mice

International journal of immunopharmacology, 1986, Vol.8 (2), p.221-226

1986

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Secretion of a suppressor cell inducing factor by an interleukin 3-dependent cell line with natural cytotoxic activity: III. Comparison with other interleukin 3-dependent cell lines

Cellular immunology, 1988-10, Vol.116 (1), p.1-11

1988

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Splenic Natural Cytotoxic Activity is Enhanced during Growth of a Murine Fibrosarcoma

Immunobiology (1979), 1990-02, Vol.180 (2), p.243-260

1990

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Kinetic Analysis of the Inhibition of Natural Killer (NK) Activity by Multiple Populations of Tumor-Activated Suppressor Cells

Immunobiology (1979), 1986-04, Vol.171 (3), p.205-219

1986

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Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstituted Guanosines and Structurally Related Compounds

Immunopharmacology: a new frontier

Suppressor cells in the spleens of tumor-bearing mice: enrichment by centrifugation on hypaque-ficoll and characterization of the suppressor population

Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells

Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac‐1 and E‐selectin expression

7-Allyl-8-oxoguanosine (loxoribine) inhibits the metastasis of B16 melanoma cells and has adjuvant activity in mice immunized with a B16 tumor vaccine

Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2

Tepoxalin, a novel immunomodulatory compound, synergizes with CsA in suppression of graft-versus-host reaction and allogeneic skin graft rejection

Enhancement of immunostimulatory activity by dual substitution of C8-substituted guanine ribonucleosides: correlation with increased cytokine secretion

A Leukocyte Lipid Up-Regulates the Avidity of Lymphocyte Function-Associated Antigen-1

The Immunostimulatory Compound 7-Allyl-8-Oxoguanosine (Loxoribine) Induces a Distinct Subset of Murine Cytokines

Secretion of a suppressor cell-inducing factor by an interleukin 3-dependent cell Line with natural cytotoxic activity. II. Range, potency, and kinetics of suppressive activity

The effect of indomethacin on the activation and effector function of suppressor cells from tumor-bearing mice

In Vivo Activation of Natural Killer Cells and Priming of IL-2 Responsive Cytolytic Cells by Loxoribine (7-Allyl-8-oxoguanosine)

Murine Strain Variation in the Natural Killer Cell and Proliferative Responses to the Immunostimulatory Compound 7-Allyl-8-oxoguanosine: Role of Cytokines

Activation of suppressor T cells by low-molecular-weight factors secreted by spleen cells from tumor-bearing mice

Enhancement of tumor growth by suppressor factors derived from a natural suppressor/cytotoxic cell line

Secretion of a suppressor cell inducing factor by an interleukin 3-dependent cell line with natural cytotoxic activity

Secretion of a suppressor cell inducing factor by an interieukin-3 dependent cell line with natural cytotoxic activity

Induction of suppression by a murine nonspecific suppressor-inducer cell line (M1-A5)

The involvement of protein kinase C, calcium, and 5-lipoxygenase in the production of tumor necrosis factor by a cloned interleukin-3 dependent cell line with natural cytotoxic activity

Requirement for prostaglandin E 1 (PGE 1) for the secretion of suppressor cell inducer factors by spleen cells of tumor-bearing mice

Secretion of a suppressor cell inducing factor by an interleukin 3-dependent cell line with natural cytotoxic activity: III. Comparison with other interleukin 3-dependent cell lines

Splenic Natural Cytotoxic Activity is Enhanced during Growth of a Murine Fibrosarcoma

Kinetic Analysis of the Inhibition of Natural Killer (NK) Activity by Multiple Populations of Tumor-Activated Suppressor Cells

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