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Pharmacological inhibition of the transcription factor PU.1 in leukemia

The Journal of clinical investigation, 2017-12, Vol.127 (12), p.4297-4313

2017

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Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing

Nature communications, 2023-05, Vol.14 (1), p.2702-2702, Article 2702

2023

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DNA mismatches reveal conformational penalties in protein-DNA recognition

Nature (London), 2020-11, Vol.587 (7833), p.291-296

2020

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The Non-continuum Nature of Eukaryotic Transcriptional Regulation

Advances in experimental medicine and biology, 2022, Vol.1371, p.11-32

2022

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ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Nature communications, 2018-07, Vol.9 (1), p.2626-13, Article 2626

2018

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Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis

Nucleic acids research, 2016-05, Vol.44 (9), p.4005-4013

2016

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Prodrug Applications for Targeted Cancer Therapy

The AAPS journal, 2014-09, Vol.16 (5), p.899-913

2014

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Differential sensitivity to methylated DNA by ETS-family transcription factors is intrinsically encoded in their DNA-binding domains

Nucleic acids research, 2016-10, Vol.44 (18), p.8671-8681

2016

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Salt bridge dynamics in protein/DNA recognition: a comparative analysis of Elk1 and ETV6

Physical chemistry chemical physics : PCCP, 2021-06, Vol.23 (24), p.1349-1352

2021

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Dissecting Knowledge, Guessing, and Blunder in Multiple Choice Assessments

Applied measurement in education, 2023-01, Vol.36 (1), p.80-98

2023

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High-resolution mapping demonstrates inhibition of DNA excision repair by transcription factors

eLife, 2022-03, Vol.11

2022

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Probing the Electrostatics and Pharmacological Modulation of Sequence-Specific Binding by the DNA-Binding Domain of the ETS Family Transcription Factor PU.1: A Binding Affinity and Kinetics Investigation

Journal of molecular biology, 2013-05, Vol.425 (10), p.1655-1669

2013

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Distinct Roles for Interfacial Hydration in Site-Specific DNA Recognition by ETS-Family Transcription Factors

The journal of physical chemistry. B, 2017-04, Vol.121 (13), p.2748-2758

2017

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Structure of an RNA G-quadruplex from the West Nile virus genome

Nature communications, 2024-06, Vol.15 (1), p.5428-10, Article 5428

2024

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Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors

Structure (London), 2024-01, Vol.32 (1), p.83-96.e4

2024

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CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma

The EMBO journal, 2021-10, Vol.40 (20), p.e107795-n/a

2021

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DNA Binding Regulates the Self-Association of the ETS Domain of PU.1 in a Sequence-Dependent Manner

Biochemistry (Easton), 2012-05, Vol.51 (20), p.4096-4107

Poon, Gregory M. K

2012

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Mapping interfacial hydration in ETS-family transcription factor complexes with DNA: a chimeric approach

Nucleic acids research, 2018-11

2018

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Heterogeneous dynamics in DNA site discrimination by the structurally homologous DNA-binding domains of ETS-family transcription factors

Nucleic acids research, 2015-04, Vol.43 (8), p.4322-4331

2015

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DNA selection by the master transcription factor PU.1

Cell reports (Cambridge), 2023-07, Vol.42 (7), p.112671-112671, Article 112671

2023

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Molecular mechanism of UV damage modulation in nucleosomes

Computational and structural biotechnology journal, 2022-01, Vol.20, p.5393-5400

2022

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Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines

Bioorganic & medicinal chemistry, 2022-08, Vol.68, p.116861-116861, Article 116861

2022

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DNA-facilitated target search by nucleoproteins: Extension of a biosensor-surface plasmon resonance method

Analytical biochemistry, 2021-09, Vol.629, p.114298-114298, Article 114298

2021

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Dissecting Dynamic and Hydration Contributions to Sequence-Dependent DNA Minor Groove Recognition

Biophysical journal, 2020-10, Vol.119 (7), p.1402-1415

2020

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Pharmacological inhibition of the transcription factor PU.1 in leukemia

Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing

DNA mismatches reveal conformational penalties in protein-DNA recognition

The Non-continuum Nature of Eukaryotic Transcriptional Regulation

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis

Prodrug Applications for Targeted Cancer Therapy

Differential sensitivity to methylated DNA by ETS-family transcription factors is intrinsically encoded in their DNA-binding domains

Salt bridge dynamics in protein/DNA recognition: a comparative analysis of Elk1 and ETV6

Dissecting Knowledge, Guessing, and Blunder in Multiple Choice Assessments

PU.1 controls fibroblast polarization and tissue fibrosis

High-resolution mapping demonstrates inhibition of DNA excision repair by transcription factors

Probing the Electrostatics and Pharmacological Modulation of Sequence-Specific Binding by the DNA-Binding Domain of the ETS Family Transcription Factor PU.1: A Binding Affinity and Kinetics Investigation

Distinct Roles for Interfacial Hydration in Site-Specific DNA Recognition by ETS-Family Transcription Factors

Structure of an RNA G-quadruplex from the West Nile virus genome

Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors

CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma

DNA Binding Regulates the Self-Association of the ETS Domain of PU.1 in a Sequence-Dependent Manner

Mapping interfacial hydration in ETS-family transcription factor complexes with DNA: a chimeric approach

Heterogeneous dynamics in DNA site discrimination by the structurally homologous DNA-binding domains of ETS-family transcription factors

DNA selection by the master transcription factor PU.1

Molecular mechanism of UV damage modulation in nucleosomes

Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines

DNA-facilitated target search by nucleoproteins: Extension of a biosensor-surface plasmon resonance method

Dissecting Dynamic and Hydration Contributions to Sequence-Dependent DNA Minor Groove Recognition

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