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Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

Osteoarthritis and cartilage, 2011-05, Vol.19 (5), p.515-542

2011

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Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage

Osteoarthritis and cartilage, 2016-08, Vol.24 (8), p.1461-1469

2016

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Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice: a cross-sectional observational study

Osteoarthritis and cartilage, 2013-06, Vol.21 (6), p.831-838

2013

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Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament

Osteoarthritis and cartilage, 2006-02, Vol.14 (2), p.114-119

2006

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Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

Osteoarthritis and cartilage, 2009-03, Vol.17 (3), p.375-383

2009

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Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice

Human molecular genetics, 2006-06, Vol.15 (11), p.1783-1792

2006

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113 ANALYSIS OF 31 BIOMARKERS AND BIOMARKER FACTORS IN PRE-RADIOGRAPHIC AND RADIOGRAPHIC KNEE OSTEOARTHRITIS: RESULTS OF A POPULATION-BASED STUDY USING MRI

Osteoarthritis and cartilage, 2009, Vol.17, p.S68-S68

2009

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Association of biomarkers with osteoarthritis progression based on MRI: results from the Vancouver knee osteoarthritis progression (KOAP) study

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S156-S156

2013

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Associations of clinical and biomarker variables with cartilage damage in painful pre-radiographic knee osteoarthritis. results from a population-based study

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S161-S161

2013

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A new sandwich biomarker assay for cartilage type ii collagen can discriminate between no osteoarthritis (oa), pre-radiographic and radiographic knee oa in human urine

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S80-S80

2012

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Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies

Osteoarthritis and cartilage, 2007-04, Vol.15 (4), p.462-467

2007

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Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration

Osteoarthritis and cartilage, 2004-09, Vol.12 (9), p.720-728

2004

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116 SERUM BIOMARKER STUDIES OF SYMPTOMATIC SUBJECTS WITH PERSISTENT KNEE PAIN WITH AND WITHOUT OA REVEAL SIGNIFICANT DIFFERENCES FROM ASYMPTOMATIC SUBJECTS IN SYSTEMIC MARKERS OF INFLAMMATION SUGGESTING DIFFERENCES IN INNATE IMMUNITY

Osteoarthritis and cartilage, 2010, Vol.18, p.S59-S59

2010

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An analysis of 14 molecular markers for monitoring osteoarthritis. Relationship of the markers to clinical end-points

Osteoarthritis and cartilage, 2001-04, Vol.9 (3), p.224-231

2001

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C2K77 ELISA detects cleavage of type II collagen by cathepsin K in equine articular cartilage

Osteoarthritis and cartilage, 2017-12, Vol.25 (12), p.2119-2126

2017

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THU0017 Deferoxamine Suppresses Collagen Cleavage in Cultured Human Osteoarthritic Articular Cartilage via A Process Involving Downregulation of Protease Activity, Proinflammatory Cytokines and Type X Collagen Expression and Upregulation of AMPK and Citric Acid Cycle Genes

Annals of the rheumatic diseases, 2016-06, Vol.75 (Suppl 2), p.183-183

2016

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Building a Local Preservation Ethic in the Era of Urban Renewal: How Did Neighborhood Associations Shape Historic Preservation Practice in Lexington, Kentucky?

Journal of urban history, 2020-03, Vol.46 (2), p.383-405

2020

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Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats

Osteoarthritis and cartilage, 2001-05, Vol.9 (4), p.308-315

2001

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Changes in subchondral bone in cartilage resurfacing—an experimental study in sheep using different types of osteochondral grafts

Osteoarthritis and cartilage, 2003-04, Vol.11 (4), p.265-277

2003

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Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog

Osteoarthritis and cartilage, 2002-08, Vol.10 (8), p.662-669

2002

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P191 EVIDENCE FOR CLEAVAGE OF TYPE II COLLAGEN BY CATHEPSIN K IN HUMAN OSTEOARTHRITIC CARTILAGE

Osteoarthritis and cartilage, 2006, Vol.14, p.S110-S110

2006

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An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline

Osteoarthritis and cartilage, 2000-05, Vol.8 (3), p.180-185

2000

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Detection and analysis of cartilage degeneration by spatially resolved streaming potentials

Journal of orthopaedic research, 2002-07, Vol.20 (4), p.819-826

2002

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Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis

Journal of orthopaedic research, 2002-11, Vol.20 (6), p.1282-1289

2002

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Proteoglycans from bovine nasal cartilage. Properties of a soluble form of link protein

The Journal of biological chemistry, 1979-10, Vol.254 (20), p.10523-10531

1979

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Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage

Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice: a cross-sectional observational study

Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament

Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice

113 ANALYSIS OF 31 BIOMARKERS AND BIOMARKER FACTORS IN PRE-RADIOGRAPHIC AND RADIOGRAPHIC KNEE OSTEOARTHRITIS: RESULTS OF A POPULATION-BASED STUDY USING MRI

Association of biomarkers with osteoarthritis progression based on MRI: results from the Vancouver knee osteoarthritis progression (KOAP) study

Associations of clinical and biomarker variables with cartilage damage in painful pre-radiographic knee osteoarthritis. results from a population-based study

A new sandwich biomarker assay for cartilage type ii collagen can discriminate between no osteoarthritis (oa), pre-radiographic and radiographic knee oa in human urine

Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies

Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration

116 SERUM BIOMARKER STUDIES OF SYMPTOMATIC SUBJECTS WITH PERSISTENT KNEE PAIN WITH AND WITHOUT OA REVEAL SIGNIFICANT DIFFERENCES FROM ASYMPTOMATIC SUBJECTS IN SYSTEMIC MARKERS OF INFLAMMATION SUGGESTING DIFFERENCES IN INNATE IMMUNITY

An analysis of 14 molecular markers for monitoring osteoarthritis. Relationship of the markers to clinical end-points

C2K77 ELISA detects cleavage of type II collagen by cathepsin K in equine articular cartilage

THU0017 Deferoxamine Suppresses Collagen Cleavage in Cultured Human Osteoarthritic Articular Cartilage via A Process Involving Downregulation of Protease Activity, Proinflammatory Cytokines and Type X Collagen Expression and Upregulation of AMPK and Citric Acid Cycle Genes

Building a Local Preservation Ethic in the Era of Urban Renewal: How Did Neighborhood Associations Shape Historic Preservation Practice in Lexington, Kentucky?

Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats

Changes in subchondral bone in cartilage resurfacing—an experimental study in sheep using different types of osteochondral grafts

Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog

P191 EVIDENCE FOR CLEAVAGE OF TYPE II COLLAGEN BY CATHEPSIN K IN HUMAN OSTEOARTHRITIC CARTILAGE

An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline

Detection and analysis of cartilage degeneration by spatially resolved streaming potentials

Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis

Proteoglycans from bovine nasal cartilage. Properties of a soluble form of link protein

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