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Drugs for bad bugs: confronting the challenges of antibacterial discovery

Nature reviews. Drug discovery, 2007-01, Vol.6 (1), p.29-40

2007

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A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

PloS one, 2008-05, Vol.3 (5), p.e2252-e2252

2008

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Drug–target residence time and its implications for lead optimization

Nature reviews. Drug discovery, 2006-08, Vol.5 (9), p.730-739

2006

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Diverse Fragment Clustering and Water Exclusion Identify Protein Hot Spots

Journal of the American Chemical Society, 2011-07, Vol.133 (28), p.10740-10743

2011

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Catalytic Properties of Mutant 23 S Ribosomes Resistant to Oxazolidinones

The Journal of biological chemistry, 2003-03, Vol.278 (11), p.9802-9807

2003

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Development of a Whole-Cell Assay for Peptidoglycan Biosynthesis Inhibitors

Antimicrobial Agents and Chemotherapy, 2002-04, Vol.46 (4), p.943-946

2002

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Anti-infective research and development—problems, challenges, and solutions

The Lancet infectious diseases, 2007, Vol.7 (1), p.68-78

2007

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Regulated Expression of the Escherichia coli lepB Gene as a Tool for Cellular Testing of Antimicrobial Compounds That Inhibit Signal Peptidase I In Vitro

Antimicrobial Agents and Chemotherapy, 2002-11, Vol.46 (11), p.3549-3554

2002

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An array of target-specific screening strains for antibacterial discovery

Nature biotechnology, 2002-05, Vol.20 (5), p.478-483

2002

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Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.725-732

1994

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Drug-target residence time and its implications for lead optimization

Nature reviews. Drug discovery, 2007-03, Vol.6 (3)

2007

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Conditionally Lethal Escherichia coli Murein Mutants Contain Point Defects That Map to Regions Conserved among Murein and Folyl Poly-γ-glutamate Ligases: Identification of a Ligase Superfamily

Biochemistry (Easton), 1997-05, Vol.36 (20), p.6223-6229

1997

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Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase

Biochemistry (Easton), 1990-04, Vol.29 (13), p.3186-3194

1990

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Oxazolidinones Mechanism of Action: Inhibition of the First Peptide Bond Formation

The Journal of biological chemistry, 2001-10, Vol.276 (40), p.37199-37205

2001

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Steady-state kinetic mechanism of ras farnesyl:protein transferase

Biochemistry (Easton), 1992-04, Vol.31 (15), p.3800-3807

1992

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A Phosphinate Inhibitor of the meso-Diaminopimelic Acid-Adding Enzyme (MurE) of Peptidoglycan Biosynthesis

Journal of organic chemistry, 1998-12, Vol.63 (26), p.10081-10085

1998

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Kinetic Mechanism of the Escherichia coli UDPMurNAc-Tripeptide d-Alanyl-d-alanine-Adding Enzyme: Use of a Glutathione S-Transferase Fusion

Biochemistry (Easton), 1996-12, Vol.35 (50), p.16264-16269

1996

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Intramolecular fluorescence enhancement: a continuous assay of Ras farnesyl:protein transferase

Journal of the American Chemical Society, 1992-09, Vol.114 (20), p.7945-7946

1992

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Homogenous Assays for Escherichia coli DnaB-Stimulated DnaG Primase and DnaB Helicase and Their Use in Screening for Chemical Inhibitors

Analytical biochemistry, 2002-05, Vol.304 (2), p.174-179

2002

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Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis

Journal of the American Chemical Society, 1999-02, Vol.121 (6), p.1175-1178

1999

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A Multitarget Assay for Inhibitors of Membrane-Associated Steps of Peptidoglycan Biosynthesis

Analytical biochemistry, 2002-07, Vol.306 (1), p.17-22

2002

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Cloning, expression and characterization of the Streptococcus pyogenes murE gene encoding a UDP-MurNAc- l-alanyl- d-glutamate: l-lysine ligase

Enzyme and microbial technology, 2004-09, Vol.35 (4), p.300-308

2004

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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway

Biochemistry (Easton), 1993-08, Vol.32 (32), p.8341-8347

1993

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PolC-Type Polymerase III of Streptococcus pyogenes and Its Use in Screening for Chemical Inhibitors

Analytical biochemistry, 2002-05, Vol.304 (1), p.110-116

2002

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2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1345-1348

1996

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

Drug–target residence time and its implications for lead optimization

Diverse Fragment Clustering and Water Exclusion Identify Protein Hot Spots

Catalytic Properties of Mutant 23 S Ribosomes Resistant to Oxazolidinones

Development of a Whole-Cell Assay for Peptidoglycan Biosynthesis Inhibitors

Anti-infective research and development—problems, challenges, and solutions

Regulated Expression of the Escherichia coli lepB Gene as a Tool for Cellular Testing of Antimicrobial Compounds That Inhibit Signal Peptidase I In Vitro

An array of target-specific screening strains for antibacterial discovery

Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

Drug-target residence time and its implications for lead optimization

Conditionally Lethal Escherichia coli Murein Mutants Contain Point Defects That Map to Regions Conserved among Murein and Folyl Poly-γ-glutamate Ligases: Identification of a Ligase Superfamily

Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase

Oxazolidinones Mechanism of Action: Inhibition of the First Peptide Bond Formation

Steady-state kinetic mechanism of ras farnesyl:protein transferase

A Phosphinate Inhibitor of the meso-Diaminopimelic Acid-Adding Enzyme (MurE) of Peptidoglycan Biosynthesis

Kinetic Mechanism of the Escherichia coli UDPMurNAc-Tripeptide d-Alanyl-d-alanine-Adding Enzyme: Use of a Glutathione S-Transferase Fusion

Intramolecular fluorescence enhancement: a continuous assay of Ras farnesyl:protein transferase

Homogenous Assays for Escherichia coli DnaB-Stimulated DnaG Primase and DnaB Helicase and Their Use in Screening for Chemical Inhibitors

Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis

A Multitarget Assay for Inhibitors of Membrane-Associated Steps of Peptidoglycan Biosynthesis

Cloning, expression and characterization of the Streptococcus pyogenes murE gene encoding a UDP-MurNAc- l-alanyl- d-glutamate: l-lysine ligase

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway

PolC-Type Polymerase III of Streptococcus pyogenes and Its Use in Screening for Chemical Inhibitors

2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase

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