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Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system

Critical care medicine, 2007-09, Vol.35 (9), p.2196-2204

2007

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The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease

PloS one, 2014-10, Vol.9 (10), p.e110162

2014

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Modulation of brain cation-Cl - cotransport via the SPAK kinase inhibitor ZT-1a

Nature communications, 2020-01, Vol.11 (1), p.78-78, Article 78

2020

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Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance

Molecular and cellular biology, 2016-11, Vol.36 (21), p.2715-2727

2016

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Phase 1 randomized trials to assess safety, pharmacokinetics, and vaginal bleeding associated with use of extended duration dapivirine and levonorgestrel vaginal rings

PloS one, 2024-06, Vol.19 (6), p.e0304552

2024

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The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function

Expert opinion on drug metabolism & toxicology, 2011-07, Vol.7 (7), p.803-816

2011

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Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

PloS one, 2017-07, Vol.12 (7), p.e0180280

2017

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Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.22

2011

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Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy

Journal of neurotrauma, 2016-03, Vol.33 (6), p.606

2016

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A microsomal based method to detect aromatase activity in different brain regions of the rat using ultra performance liquid chromatography–mass spectrometry

The Journal of steroid biochemistry and molecular biology, 2016-10, Vol.163, p.113-120

2016

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20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats

Journal of cerebral blood flow and metabolism, 2015-11, Vol.35 (11), p.1757-1763

2015

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Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond

Frontiers in neurology, 2018-08, Vol.9, p.640-640

2018

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Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest

Critical care medicine, 2012-04, Vol.40 (4), p.1221-1228

2012

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The Nuclear Splicing Factor RNA Binding Motif 5 Promotes Caspase Activation in Human Neuronal Cells, and Increases after Traumatic Brain Injury in Mice

Journal of cerebral blood flow and metabolism, 2015-04, Vol.35 (4), p.655-666

2015

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Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites

Neurotoxicology (Park Forest South), 2013-12, Vol.39, p.35-44

2013

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Variation in Anticonvulsant Selection and Electroencephalographic Monitoring Following Severe Traumatic Brain Injury in Children-Understanding Resource Availability in Sites Participating in a Comparative Effectiveness Study

Pediatric critical care medicine, 2016-07, Vol.17 (7), p.649-657

2016

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Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration

The Journal of clinical investigation, 2020-06, Vol.130 (6), p.3124-3136

2020

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Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury

Neurobiology of disease, 2011-02, Vol.41 (2), p.318-328

2011

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Lipid Emulsion Combined with Epinephrine and Vasopressin Does Not Improve Survival in a Swine Model of Bupivacaine-induced Cardiac Arrest

Anesthesiology (Philadelphia), 2009-07, Vol.111 (1), p.138-146

2009

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The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology

Clinical pharmacology and therapeutics, 2020-07, Vol.108 (1), p.40-53

2020

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Rapid, simultaneous quantitation of mono and dioxygenated metabolites of arachidonic acid in human CSF and rat brain

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-12, Vol.877 (31), p.3991-4000

2009

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Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice

Hepatology (Baltimore, Md.), 2011-12, Vol.54 (6), p.2208-2217

2011

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A Modeling-Based Approach to Estimate Fentanyl Pharmacokinetics in Obese Critically Ill Children

Pediatric critical care medicine, 2019-12, Vol.20 (12), p.1208

2019

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COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest

Brain research, 2013-06, Vol.1519, p.71-77

2013

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Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

Hepatology (Baltimore, Md.), 2005-03, Vol.41 (3), p.497-505

2005

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Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system

The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease

Modulation of brain cation-Cl - cotransport via the SPAK kinase inhibitor ZT-1a

Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance

Phase 1 randomized trials to assess safety, pharmacokinetics, and vaginal bleeding associated with use of extended duration dapivirine and levonorgestrel vaginal rings

The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function

Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy

A microsomal based method to detect aromatase activity in different brain regions of the rat using ultra performance liquid chromatography–mass spectrometry

20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats

Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond

Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest

The Nuclear Splicing Factor RNA Binding Motif 5 Promotes Caspase Activation in Human Neuronal Cells, and Increases after Traumatic Brain Injury in Mice

Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites

Variation in Anticonvulsant Selection and Electroencephalographic Monitoring Following Severe Traumatic Brain Injury in Children-Understanding Resource Availability in Sites Participating in a Comparative Effectiveness Study

Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury

Lipid Emulsion Combined with Epinephrine and Vasopressin Does Not Improve Survival in a Swine Model of Bupivacaine-induced Cardiac Arrest

The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology

Rapid, simultaneous quantitation of mono and dioxygenated metabolites of arachidonic acid in human CSF and rat brain

Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice

A Modeling-Based Approach to Estimate Fentanyl Pharmacokinetics in Obese Critically Ill Children

COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

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