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Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2022-09, Vol.112 (3), p.573-592

2022

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Exploring predictors of HIV-1 virologic failure to long-acting cabotegravir and rilpivirine: a multivariable analysis

AIDS (London), 2021-07, Vol.35 (9), p.1333-1342

2021

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Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.900-915

2018

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.916-932

2018

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Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds

Drug metabolism and disposition, 2021-02, Vol.49 (2), p.169-178

2021

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Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design

Drug metabolism and disposition, 2015-04, Vol.43 (4), p.490-509

2015

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Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer

Pharmaceutical research, 2012-03, Vol.29 (3), p.770-781

2012

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An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016)

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.439

2009

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The Role of Efflux and Uptake Transporters in N -{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) Disposition and Drug Interactions

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.695-701

2008

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In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates

Drug metabolism and disposition, 2006-05, Vol.34 (5), p.786-792

2006

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs

The Journal of pharmacology and experimental therapeutics, 2002-12, Vol.303 (3), p.1029-1037

2002

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Practical dosing guidance for the management of clinician-administered injections of long-acting cabotegravir and rilpivirine

Therapeutic Advances in Infectious Disease, 2023-01, Vol.10

2023

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Membrane transporters in drug development

Nature reviews. Drug discovery, 2010-03, Vol.9 (3), p.215-236

2010

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Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.452-460

2008

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In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor

Drug metabolism and disposition, 2013-02, Vol.41 (2), p.353-361

2013

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Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies

Journal of pharmaceutical sciences, 2021-04, Vol.110 (4), p.1601-1614

2021

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Oral Sulfasalazine as a Clinical BCRP Probe Substrate: Pharmacokinetic Effects of Genetic Variation (C421A) and Pantoprazole Coadministration

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.1046-1062

2010

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Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

Pharmaceutical research, 1999-08, Vol.16 (8), p.1206-1212

1999

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Efficacy, Safety, and Pharmacokinetics by Body Mass Index Category in Phase 3/3b Long-Acting Cabotegravir Plus Rilpivirine Trials

The Journal of infectious diseases, 2024-07, Vol.230 (1), p.e34-e42

2024

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Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.754

2001

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Pregnancy outcomes and pharmacokinetics in pregnant women living with HIV exposed to long‐acting cabotegravir and rilpivirine in clinical trials

HIV medicine, 2023-05, Vol.24 (5), p.568-579

2023

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Understanding the transport properties of metabolites: case studies and considerations for drug development

Drug metabolism and disposition, 2014-04, Vol.42 (4), p.650-664

2014

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Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier

Journal of pharmaceutical sciences, 2004-08, Vol.93 (8), p.2108-2123

2004

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Mechanistic Basis of Cabotegravir-Glucuronide Disposition in Humans

The Journal of pharmacology and experimental therapeutics, 2019-08, Vol.370 (2), p.269-277

2019

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Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

Exploring predictors of HIV-1 virologic failure to long-acting cabotegravir and rilpivirine: a multivariable analysis

Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds

Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design

Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer

An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016)

The Role of Efflux and Uptake Transporters in N -{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) Disposition and Drug Interactions

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs

Practical dosing guidance for the management of clinician-administered injections of long-acting cabotegravir and rilpivirine

Membrane transporters in drug development

Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor

Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies

Oral Sulfasalazine as a Clinical BCRP Probe Substrate: Pharmacokinetic Effects of Genetic Variation (C421A) and Pantoprazole Coadministration

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

Efficacy, Safety, and Pharmacokinetics by Body Mass Index Category in Phase 3/3b Long-Acting Cabotegravir Plus Rilpivirine Trials

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

Pregnancy outcomes and pharmacokinetics in pregnant women living with HIV exposed to long‐acting cabotegravir and rilpivirine in clinical trials

Understanding the transport properties of metabolites: case studies and considerations for drug development

Expanded Multivariable Models to Assist Patient Selection for Long-Acting Cabotegravir + Rilpivirine Treatment: Clinical Utility of a Combination of Patient, Drug Concentration, and Viral Factors Associated With Virologic Failure

Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier

Mechanistic Basis of Cabotegravir-Glucuronide Disposition in Humans

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