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Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models

Scientific reports, 2022-11, Vol.12 (1), p.20435-20435, Article 20435

2022

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Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice

The Journal of clinical investigation, 2002, Vol.109 (6), p.745-753

2002

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A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome

PloS one, 2022-01, Vol.17 (1), p.e0257929

2022

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High Glucose Activates YAP Signaling to Promote Vascular Inflammation

Frontiers in physiology, 2021-06, Vol.12, p.665994-665994

2021

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PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo

JACC. Basic to translational science, 2016-10, Vol.1 (6), p.419-427

2016

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Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats

European journal of pharmacology, 2006-03, Vol.534 (1-3), p.271-279

2006

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A G-protein-biased S1P.sub.1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome

PloS one, 2022-01, Vol.17 (1), p.e0257929

2022

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R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases

British journal of pharmacology, 2024-07, Vol.181 (13), p.1993-2011

2024

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Apelin improves cardiac function mainly through peripheral vasodilation in a mouse model of dilated cardiomyopathy

Peptides (New York, N.Y. : 1980), 2021-08, Vol.142, p.170568-170568, Article 170568

2021

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Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient trial

British journal of clinical pharmacology, 2021-05, Vol.87 (5), p.2303-2320

2021

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Oxidative stress occurs in absence of hyperglycaemia and inflammation in the onset of kidney lesions in normotensive obese rats

Nephrology, dialysis, transplantation, 2000-04, Vol.15 (4), p.467-476

2000

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Potential Therapeutic Value of Urotensin II Receptor Antagonist in Chronic Kidney Disease and Associated Comorbidities

The Journal of pharmacology and experimental therapeutics, 2020-07, Vol.374 (1), p.24-37

2020

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The complexity of lipoprotein (a) lowering by PCSK9 monoclonal antibodies

Clinical science (1979), 2017-02, Vol.131 (4), p.261-268

2017

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PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate

Clinical science (1979), 2018-05, Vol.132 (10), p.1075-1083

2018

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A G protein–biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

Science signaling, 2020-06, Vol.13 (634)

2020

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The anti-obesity effect of rimonabant is associated with an improved serum lipid profile

Diabetes, obesity & metabolism, 2005-01, Vol.7 (1), p.65-72

2005

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Alirocumab efficiently reduces Lp(a) levels by lowering apolipoprotein (a) [apo(a)] production rate in non-human primates (NHP)

Atherosclerosis, 2017-08, Vol.263, p.e27-e27

2017

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PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab

JACC. Basic to translational science, 2016-10, Vol.1 (6), p.419-427

2016

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A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome

PloS one, 2022-01, Vol.17 (1), p.e0257929

2022

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Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab

JACC. Basic to translational science, 2020-06, Vol.5 (6), p.549-557

2020

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Modulation of Endothelial Cell Function by Normal Polyspecific Human Intravenous Immunoglobulins

The American journal of pathology, 1998-10, Vol.153 (4), p.1257-1266

1998

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The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease

Arteriosclerosis, thrombosis, and vascular biology, 2006-02, Vol.26 (2), p.353-358

2006

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High levels of myocardial antioxidant defense in aging nondiabetic normotensive Zucker obese rats

American journal of physiology. Regulatory, integrative and comparative physiology, 2004-04, Vol.286 (4), p.793-R800

2004

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Modulation of Endothelial Cell Function by Normal Polyspecific Human Intravenous Immunoglobulins : A Possible Mechanism of Action in Vascular Diseases

The American journal of pathology, 1998-10, Vol.153 (4), p.1257-1266

1998

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Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models

Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice

A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome

High Glucose Activates YAP Signaling to Promote Vascular Inflammation

PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo

Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats

A G-protein-biased S1P.sub.1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome

R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases

Apelin improves cardiac function mainly through peripheral vasodilation in a mouse model of dilated cardiomyopathy

Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin‑2 for Cardiovascular Diseases

Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient trial

Oxidative stress occurs in absence of hyperglycaemia and inflammation in the onset of kidney lesions in normotensive obese rats

Potential Therapeutic Value of Urotensin II Receptor Antagonist in Chronic Kidney Disease and Associated Comorbidities

The complexity of lipoprotein (a) lowering by PCSK9 monoclonal antibodies

PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate

A G protein–biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

The anti-obesity effect of rimonabant is associated with an improved serum lipid profile

Alirocumab efficiently reduces Lp(a) levels by lowering apolipoprotein (a) [apo(a)] production rate in non-human primates (NHP)

PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab

A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome

Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab

Modulation of Endothelial Cell Function by Normal Polyspecific Human Intravenous Immunoglobulins

The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease

High levels of myocardial antioxidant defense in aging nondiabetic normotensive Zucker obese rats

Modulation of Endothelial Cell Function by Normal Polyspecific Human Intravenous Immunoglobulins : A Possible Mechanism of Action in Vascular Diseases

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