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Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

PloS one, 2019-03, Vol.14 (3), p.e0214545

2019

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Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation

PloS one, 2010-09, Vol.5 (9), p.e12733

2010

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Cytochrome P450 2J2: potential role in drug metabolism and cardiotoxicity

Drug metabolism and disposition, 2018-08, Vol.46 (8), p.1053-1065

2018

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Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

Toxicological sciences, 2016-07, Vol.152 (1), p.99-112

2016

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Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes

Toxicological sciences, 2015-04, Vol.144 (2), p.227-237

2015

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Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity

Toxicological sciences, 2013-04, Vol.132 (2), p.317-326

2013

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On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Scientific reports, 2019-07, Vol.9 (1), p.9619-14, Article 9619

2019

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Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics

Nature communications, 2023-08, Vol.14 (1), p.4653-4653, Article 4653

2023

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Anticancer drugs and cardiotoxicity: the role of cardiomyocyte and non-cardiomyocyte cells

Frontiers in cardiovascular medicine, 2024-07, Vol.11

2024

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Enhanced characterization of contractility in cardiomyocytes during early drug safety assessment

Toxicological sciences, 2015-06, Vol.145 (2), p.396-406

2015

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RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses

Frontiers in cardiovascular medicine, 2024-07, Vol.11

2024

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From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery

Toxicological sciences, 2017-02, Vol.155 (2), p.444-457

2017

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An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues

Metabolites, 2021-09, Vol.11 (9), p.644

2021

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Investigating signaling mechanisms of structural cardiotoxicity via in situ single cell analysis by TOBis IMC on heterocellular cardiac organoids

Journal of molecular and cellular cardiology, 2022-12, Vol.173, p.167-169

2022

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Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology

Scientific reports, 2018-07, Vol.8 (1), p.10160-15, Article 10160

2018

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Utilising FRAP to Assess Cx-43 Uncoupling in Spontaneously-beating Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPS-CMs)

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.235-236

2017

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Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Annual review of pharmacology and toxicology, 2018-01, Vol.58, p.65

2018

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Pivotal Role for Two Electron Reduction in 2,3-Dimethoxy-1,4-naphthoquinone and 2-Methyl-1,4-naphthoquinone Metabolism and Kinetics in Vivo That Prevents Liver Redox Stress

Chemical research in toxicology, 2009-04, Vol.22 (4), p.717-725

2009

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Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration

Circulation (New York, N.Y.), 2024-05, Vol.149 (22), p.1704

2024

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In vitro detection of cardiotoxicity using the rat-derived H9c2 cardiomyocyte cell line

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e13-e14

2011

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Current and future approaches to nonclinical cardiovascular safety assessment

Drug discovery today, 2020-07, Vol.25 (7), p.1129-1134

2020

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Characterising the mechanisms of drug-induced structural cardiotoxicity

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.123-123

2018

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A pharmacological characterization of electrocardiogram PR and QRS intervals in conscious telemetered rats

Journal of pharmacological and toxicological methods, 2020-03, Vol.102, p.106679-106679, Article 106679

2020

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Intra- and intercellular signaling pathways associated with drug-induced cardiac pathophysiology

Trends in pharmacological sciences (Regular ed.), 2021-08, Vol.42 (8), p.675-687

2021

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Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes

Cell stem cell, 2024-03, Vol.31 (3), p.292-311

2024

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Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation

Cytochrome P450 2J2: potential role in drug metabolism and cardiotoxicity

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes

Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics

Anticancer drugs and cardiotoxicity: the role of cardiomyocyte and non-cardiomyocyte cells

Enhanced characterization of contractility in cardiomyocytes during early drug safety assessment

RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery

An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues

Investigating signaling mechanisms of structural cardiotoxicity via in situ single cell analysis by TOBis IMC on heterocellular cardiac organoids

Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology

Utilising FRAP to Assess Cx-43 Uncoupling in Spontaneously-beating Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPS-CMs)

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Pivotal Role for Two Electron Reduction in 2,3-Dimethoxy-1,4-naphthoquinone and 2-Methyl-1,4-naphthoquinone Metabolism and Kinetics in Vivo That Prevents Liver Redox Stress

Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration

In vitro detection of cardiotoxicity using the rat-derived H9c2 cardiomyocyte cell line

Current and future approaches to nonclinical cardiovascular safety assessment

Characterising the mechanisms of drug-induced structural cardiotoxicity

A pharmacological characterization of electrocardiogram PR and QRS intervals in conscious telemetered rats

Intra- and intercellular signaling pathways associated with drug-induced cardiac pathophysiology

Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes

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