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Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling

American journal of physiology. Lung cellular and molecular physiology, 2015-05, Vol.308 (9), p.L931-L942

2015

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A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABAA Receptor

Molecules (Basel, Switzerland), 2020-08, Vol.25 (17), p.3864

2020

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Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition

Cell death & disease, 2019-09, Vol.10 (10), p.733-12, Article 733

2019

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Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.914-918

2017

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Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator

Frontiers in pharmacology, 2016-11, Vol.7, p.446-446

2016

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8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor

Frontiers in pharmacology, 2021-04, Vol.12, p.625233-625233

2021

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GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

Pharmacology & therapeutics (Oxford), 2022-06, Vol.234, p.108035-108035, Article 108035

2022

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Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression

ARKIVOC free online journal of organic chemistry, 2018-03, Vol.2018 (4), p.158-182

2018

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Regulating anxiety with extrasynaptic inhibition

Nature neuroscience, 2015-10, Vol.18 (10), p.1493-1500

2015

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A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

International Journal of Medicinal Chemistry (Online), 2015-01, Vol.2015, p.1-54

2015

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The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region

The FASEB journal, 2017-11, Vol.31 (11), p.4697-4706

2017

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Prior Antipsychotic Drug Treatment Prevents Response to Novel Antipsychotic Agent in the Methylazoxymethanol Acetate Model of Schizophrenia

Schizophrenia bulletin, 2014-03, Vol.40 (2), p.341-350

2014

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Synergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024): a positive allosteric modulator at α2GABAA and α3GABAA receptors

Psychopharmacology, 2021-06, Vol.238 (6), p.1585-1592

2021

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Assessing the synergistic effects of morphine and MP‐III‐024 co‐administration: enhanced antinociception with reduced side effects

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Synthesis and Characterization of a Novel γ‑Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy

Journal of medicinal chemistry, 2016-12, Vol.59 (23), p.10800-10806

2016

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Probing the Ligand-Binding Pocket of BTN3A1

Journal of medicinal chemistry, 2019-07, Vol.62 (14), p.6814-6823

2019

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Negative allosteric modulation of alpha 5-containing GABA A receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice

Psychopharmacology (Berlin, Germany), 2018-04, Vol.235 (4), p.1151

2018

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Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024

Brain research bulletin, 2017-05, Vol.131, p.62-69

2017

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Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2373-2382

2017

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Positive and Negative Selective Allosteric Modulators of α5 GABAA Receptors: Effects on Emotionality, Motivation, and Motor Function in the 5xFAD Model of Alzheimer's Disease

Journal of Alzheimer's disease, 2021, Vol.84 (3), p.1291-1302

2021

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Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats

Neuroscience, 2017-03, Vol.346, p.349-364

2017

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Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice

Psychopharmacology, 2018-04, Vol.235 (4), p.1151-1161

2018

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Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats

Psychopharmacology, 2017-07, Vol.234 (14), p.2091-2101

2017

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Abuse-related effects of subtype-selective GABA A receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats

Psychopharmacology (Berlin, Germany), 2017-07, Vol.234 (14), p.2091

2017

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Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABAA Receptor Positive Allosteric Modulator

ACS chemical neuroscience, 2017-06, Vol.8 (6), p.1305-1312

2017

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Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling

A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABAA Receptor

Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition

Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator

8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor

GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression

Regulating anxiety with extrasynaptic inhibition

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region

Prior Antipsychotic Drug Treatment Prevents Response to Novel Antipsychotic Agent in the Methylazoxymethanol Acetate Model of Schizophrenia

Synergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024): a positive allosteric modulator at α2GABAA and α3GABAA receptors

Assessing the synergistic effects of morphine and MP‐III‐024 co‐administration: enhanced antinociception with reduced side effects

Synthesis and Characterization of a Novel γ‑Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy

Probing the Ligand-Binding Pocket of BTN3A1

Negative allosteric modulation of alpha 5-containing GABA A receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice

Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024

Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism

Positive and Negative Selective Allosteric Modulators of α5 GABAA Receptors: Effects on Emotionality, Motivation, and Motor Function in the 5xFAD Model of Alzheimer's Disease

Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats

Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice

Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats

Abuse-related effects of subtype-selective GABA A receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats

Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABAA Receptor Positive Allosteric Modulator

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