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The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase

Chemical reviews, 2017-08, Vol.117 (15), p.10474-10501

2017

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From intrinsically disordered protein to context-dependent folding: The α-synuclein tetramer is teased out of hiding

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (31), p.9502-9503

Pochapsky, Thomas C.

2015

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soluble α-synuclein construct forms a dynamic tetramer

Proceedings of the National Academy of Sciences - PNAS, 2011-10, Vol.108 (43), p.17797-17802

2011

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Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures

Nature communications, 2015-02, Vol.6 (1), p.6165, Article 6165

2015

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Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG

Biochemistry (Easton), 2017-05, Vol.56 (21), p.2701-2714

2017

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Examining how enzymes self-organize in a membrane

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (10), p.3659-3660

Pochapsky, Thomas C.

2014

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A dynamic understanding of cytochrome P450 structure and function through solution NMR

Current opinion in biotechnology, 2021-06, Vol.69, p.35-42

Pochapsky, Thomas C

2021

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Substrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation Reactions

The Journal of biological chemistry, 2012-11, Vol.287 (45), p.37880-37890

2012

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What Your Crystal Structure Will Not Tell You about Enzyme Function

Accounts of chemical research, 2019-05, Vol.52 (5), p.1409-1418

2019

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Communication between the Zinc and Nickel Sites in Dimeric HypA: Metal Recognition and pH Sensing

Journal of the American Chemical Society, 2010-08, Vol.132 (30), p.10338-10351

2010

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Human Acireductone Dioxygenase (HsARD), Cancer and Human Health: Black Hat, White Hat or Gray?

Inorganics, 2019-08, Vol.7 (8), p.101

2019

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Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles

Communications chemistry, 2023-09, Vol.6 (1), p.183-183, Article 183

2023

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Conformational plasticity and structure/function relationships in cytochromes P450

Antioxidants & redox signaling, 2010-10, Vol.13 (8), p.1273-1296

2010

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A Functional Proline Switch in Cytochrome P450cam

Structure (London), 2008-06, Vol.16 (6), p.916-923

2008

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Solution NMR Structure of Putidaredoxin–Cytochrome P450cam Complex via a Combined Residual Dipolar Coupling–Spin Labeling Approach Suggests a Role for Trp106 of Putidaredoxin in Complex Formation

Journal of molecular biology, 2008-12, Vol.384 (2), p.349-363

2008

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Tracking protein–protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b5

Physical chemistry chemical physics : PCCP, 2024-06, Vol.26 (24), p.16980-16988

2024

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Hydroxylation Regiochemistry Is Robust to Active Site Mutations in Cytochrome P450cam (CYP101A1)

Biochemistry (Easton), 2022-09, Vol.61 (17), p.1790-1800

2022

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Conformational heterogeneity suggests multiple substrate binding modes in CYP106A2

Journal of inorganic biochemistry, 2023-04, Vol.241, p.112129-112129, Article 112129

2023

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A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions with the Regulatory Domain of Matrix Metalloproteinase I (MMP-I)

Biochemistry (Easton), 2020-11, Vol.59 (44), p.4238-4249

2020

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Hydroxylation Regiochemistry Is Robust to Active Site Mutations in Cytochrome P450 cam (CYP101A1)

Biochemistry (Easton), 2022-09, Vol.61 (17), p.1790-1800

2022

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Mechanistic Studies of Two Dioxygenases in the Methionine Salvage Pathway of Klebsiella pneumoniae

Biochemistry (Easton), 2001-05, Vol.40 (21), p.6379-6387

2001

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One Protein, Two Enzymes Revisited: A Structural Entropy Switch Interconverts the Two Isoforms of Acireductone Dioxygenase

Journal of molecular biology, 2006-11, Vol.363 (4), p.823-834

2006

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Steroid‐Derived Isonitriles are Potent Cytochrome P450 Ligands that Should Enable Solution NMR as a Structural Technique to Probe P450 Dynamics

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b 5

Physical chemistry chemical physics : PCCP, 2024-06, Vol.26 (24), p.16980-16988

2024

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Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450cam (CYP101A1)

Journal of molecular biology, 2018-04, Vol.430 (9), p.1295-1310

2018

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The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase

From intrinsically disordered protein to context-dependent folding: The α-synuclein tetramer is teased out of hiding

soluble α-synuclein construct forms a dynamic tetramer

Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures

Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG

Examining how enzymes self-organize in a membrane

A dynamic understanding of cytochrome P450 structure and function through solution NMR

Substrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation Reactions

What Your Crystal Structure Will Not Tell You about Enzyme Function

Communication between the Zinc and Nickel Sites in Dimeric HypA: Metal Recognition and pH Sensing

Human Acireductone Dioxygenase (HsARD), Cancer and Human Health: Black Hat, White Hat or Gray?

Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles

Conformational plasticity and structure/function relationships in cytochromes P450

A Functional Proline Switch in Cytochrome P450cam

Solution NMR Structure of Putidaredoxin–Cytochrome P450cam Complex via a Combined Residual Dipolar Coupling–Spin Labeling Approach Suggests a Role for Trp106 of Putidaredoxin in Complex Formation

Tracking protein–protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b5

Hydroxylation Regiochemistry Is Robust to Active Site Mutations in Cytochrome P450cam (CYP101A1)

Conformational heterogeneity suggests multiple substrate binding modes in CYP106A2

A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions with the Regulatory Domain of Matrix Metalloproteinase I (MMP-I)

Hydroxylation Regiochemistry Is Robust to Active Site Mutations in Cytochrome P450 cam (CYP101A1)

Mechanistic Studies of Two Dioxygenases in the Methionine Salvage Pathway of Klebsiella pneumoniae

One Protein, Two Enzymes Revisited: A Structural Entropy Switch Interconverts the Two Isoforms of Acireductone Dioxygenase

Steroid‐Derived Isonitriles are Potent Cytochrome P450 Ligands that Should Enable Solution NMR as a Structural Technique to Probe P450 Dynamics

Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b 5

Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450cam (CYP101A1)

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