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Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

Neurobiology of disease, 2020-10, Vol.144, p.105010-105010, Article 105010

2020

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (9), p.3620-3625

2014

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SOD1 exhibits allosteric frustration to facilitate metal binding affinity

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3871-3876

2013

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A systematically coarse-grained model for DNA and its predictions for persistence length, stacking, twist, and chirality

The Journal of chemical physics, 2010-01, Vol.132 (3), p.035105-035105

2010

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Intermolecular transmission of Superoxide dismutase 1 misfolding in living cells

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (39), p.16398-16403

2011

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As Simple As Possible, but Not Simpler: Exploring the Fidelity of Coarse-Grained Protein Models for Simulated Force Spectroscopy

PLoS computational biology, 2016-11, Vol.12 (11), p.e1005211-e1005211

2016

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A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease

Scientific reports, 2019-07, Vol.9 (1), p.9870-14, Article 9870

2019

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De Novo Design of a β‑Helix Tau Protein Scaffold: An Oligomer-Selective Vaccine Immunogen Candidate for Alzheimer’s Disease

ACS chemical neuroscience, 2023-08, Vol.14 (15), p.2603-2617

2023

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Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells

Open biology, 2024-06, Vol.14 (6), p.230418

2024

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The effects of nonnative interactions on protein folding rates: Theory and simulation

Protein science, 2004-07, Vol.13 (7), p.1750-1766

2004

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A theory for the anisotropic and inhomogeneous dielectric properties of proteins

Physical chemistry chemical physics : PCCP, 2011-04, Vol.13 (13), p.6286-6295

2011

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First Principles Calculation of Protein-Protein Dimer Affinities of ALS-Associated SOD1 Mutants

Frontiers in molecular biosciences, 2022-03, Vol.9, p.845013

2022

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Assessment of protein inclusions in cultured cells using automated image analysis

STAR protocols, 2022-12, Vol.3 (4), p.101748-101748, Article 101748

2022

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Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases

iScience, 2020-06, Vol.23 (6), p.101159-101159, Article 101159

2020

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Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

Frontiers in molecular neuroscience, 2020-01, Vol.12, p.311-311

2020

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Polymer uncrossing and knotting in protein folding, and their role in minimal folding pathways

PloS one, 2013-01, Vol.8 (1), p.e53642-e53642

2013

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Misfolding-Associated Exposure of Natively Buried Residues in Mutant SOD1 Facilitates Binding to TRAF6

Journal of molecular biology, 2022-08, Vol.434 (16), p.167697-167697, Article 167697

2022

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Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein

Biomedicines, 2022-09, Vol.10 (9), p.2168

2022

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Testing the feasibility of targeting a conserved region on the S2 domain of the SARS-CoV-2 spike protein

Biophysical journal, 2024-04, Vol.123 (8), p.992-1005

2024

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Prediction of Misfolding-Specific Epitopes in SOD1 Using Collective Coordinates

The journal of physical chemistry. B, 2018-12, Vol.122 (49), p.11662-11676

2018

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Ensemble Generation for Linear and Cyclic Peptides Using a Reservoir Replica Exchange Molecular Dynamics Implementation in GROMACS

The journal of physical chemistry. B, 2022-12, Vol.126 (49), p.10384-10399

2022

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Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases

CNS drugs, 2019-09, Vol.33 (9), p.883-904

2019

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Generalization of distance to higher dimensional objects

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (38), p.14899-14904

Plotkin, Steven S

2007

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Cyclization Scaffolding for Improved Vaccine Immunogen Stability: Application to Tau Protein in Alzheimer’s Disease

Journal of chemical information and modeling, 2024-03, Vol.64 (6), p.2035-2044

2024

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PROTHON: A Local Order Parameter-Based Method for Efficient Comparison of Protein Ensembles

Journal of chemical information and modeling, 2023-06, Vol.63 (11), p.3453-3461

2023

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Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

SOD1 exhibits allosteric frustration to facilitate metal binding affinity

A systematically coarse-grained model for DNA and its predictions for persistence length, stacking, twist, and chirality

Intermolecular transmission of Superoxide dismutase 1 misfolding in living cells

As Simple As Possible, but Not Simpler: Exploring the Fidelity of Coarse-Grained Protein Models for Simulated Force Spectroscopy

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease

De Novo Design of a β‑Helix Tau Protein Scaffold: An Oligomer-Selective Vaccine Immunogen Candidate for Alzheimer’s Disease

Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells

The effects of nonnative interactions on protein folding rates: Theory and simulation

A theory for the anisotropic and inhomogeneous dielectric properties of proteins

First Principles Calculation of Protein-Protein Dimer Affinities of ALS-Associated SOD1 Mutants

Assessment of protein inclusions in cultured cells using automated image analysis

Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

Polymer uncrossing and knotting in protein folding, and their role in minimal folding pathways

Misfolding-Associated Exposure of Natively Buried Residues in Mutant SOD1 Facilitates Binding to TRAF6

Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein

Testing the feasibility of targeting a conserved region on the S2 domain of the SARS-CoV-2 spike protein

Prediction of Misfolding-Specific Epitopes in SOD1 Using Collective Coordinates

Ensemble Generation for Linear and Cyclic Peptides Using a Reservoir Replica Exchange Molecular Dynamics Implementation in GROMACS

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases

Generalization of distance to higher dimensional objects

Cyclization Scaffolding for Improved Vaccine Immunogen Stability: Application to Tau Protein in Alzheimer’s Disease

PROTHON: A Local Order Parameter-Based Method for Efficient Comparison of Protein Ensembles

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