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Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7043-7066

2017

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Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation

American journal of physiology. Lung cellular and molecular physiology, 1999-07, Vol.277 (1), p.65-L78

1999

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Conflicting evidence for the role of JNK as a target in breast cancer cell proliferation: Comparisons between pharmacological inhibition and selective shRNA knockdown approaches

Pharmacology research & perspectives, 2018-02, Vol.6 (1), p.n/a

2018

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Phosphatidylinositol 3′-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling: Wortmannin inhibits glucose transport and downregulates cell-surface transferrin receptor numbers independently of any effect on fluid-phase endocytosis in fibroblasts

Cellular signalling, 1996-06, Vol.8 (4), p.297-304

1996

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Evidence for a role of phosphatidylinositol 3-kinase in the regulation of glucose transport in Xenopus oocytes

The Journal of biological chemistry, 1994-10, Vol.269 (43), p.26622-26625

1994

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Growth factor-induced stimulation of hexose transport in 3T3-L1 adipocytes: Evidence that insulin-induced translocation of glut4 is independent of activation of MAP kinase

Cellular signalling, 1994-03, Vol.6 (3), p.313-320

1994

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MAP kinase may play a role in the early phase of glucose transport in insulin treated 3T3-L1 fibroblasts

Biochemical Society transactions, 1993-11, Vol.21 (4), p.355S-355S

1993

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Mammalian glucose transporters: intracellular signalling and transporter translocation

Biochemical Society transactions, 1994-08, Vol.22 (3), p.664-667

1994

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Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation

American journal of physiology. Lung cellular and molecular physiology, 1999-07, Vol.277 (1), p.L65

1999

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The possible involvement of changes in phosphoinositol turnover in the responses of renal sodium transport to noradrenaline

Biochemical pharmacology, 1988-06, Vol.37 (11), p.2121-2124

1988

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Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Annals of the rheumatic diseases, 2016-11, Vol.75 (11), p.1989-1997

2016

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Proteinase-activated receptors

Pharmacological reviews, 2001-06, Vol.53 (2), p.245

2001

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Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

Chemical science (Cambridge), 2018, Vol.9 (25), p.5585-5593

2018

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Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3- b ]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

Molecules (Basel, Switzerland), 2024-08, Vol.29 (15), p.3515

2024

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Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival

Human molecular genetics, 2018-07, Vol.27 (13), p.2290-2305

2018

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Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome

Frontiers in cellular neuroscience, 2022-07, Vol.16, p.917181-917181

2022

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Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory

The Journal of neuroscience, 2016-02, Vol.36 (8), p.2348-2354

2016

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Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1017-1024

2006

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Essential role for proteinase-activated receptor-2 in arthritis

The Journal of clinical investigation, 2003-01, Vol.111 (1), p.35-41

2003

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Design and Synthesis of Novel Aminoindazole-pyrrolo2,3-bpyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

Molecules (Basel, Switzerland), 2024-07, Vol.29 (15)

2024

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Mitogen‐activated protein kinase phosphatase‐2 deletion modifies ventral tegmental area function and connectivity and alters reward processing

The European journal of neuroscience, 2020-07, Vol.52 (2), p.2838-2852

2020

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Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts

Pflügers Archiv, 2014-02, Vol.466 (2), p.319-330

2014

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Protease-Activated Receptor 2: Are Common Functions in Glial and Immune Cells Linked to Inflammation-Related CNS Disorders?

Current drug targets, 2016-01, Vol.17 (16), p.1861-1870

2016

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Inhibition of Lipopolysaccharide-Induced Macrophage IL-12 Production by Leishmania mexicana Amastigotes: The Role of Cysteine Peptidases and the NF-κB Signaling Pathway

The Journal of immunology (1950), 2004-09, Vol.173 (5), p.3297-3304

2004

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Determining the prognostic significance of IKKα in prostate cancer

The Prostate, 2020-10, Vol.80 (14), p.1188-1202

2020

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Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation

Conflicting evidence for the role of JNK as a target in breast cancer cell proliferation: Comparisons between pharmacological inhibition and selective shRNA knockdown approaches

Phosphatidylinositol 3′-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling: Wortmannin inhibits glucose transport and downregulates cell-surface transferrin receptor numbers independently of any effect on fluid-phase endocytosis in fibroblasts

Evidence for a role of phosphatidylinositol 3-kinase in the regulation of glucose transport in Xenopus oocytes

Growth factor-induced stimulation of hexose transport in 3T3-L1 adipocytes: Evidence that insulin-induced translocation of glut4 is independent of activation of MAP kinase

MAP kinase may play a role in the early phase of glucose transport in insulin treated 3T3-L1 fibroblasts

Mammalian glucose transporters: intracellular signalling and transporter translocation

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation

The possible involvement of changes in phosphoinositol turnover in the responses of renal sodium transport to noradrenaline

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Proteinase-activated receptors

Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3- b ]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival

Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome

Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory

Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

Essential role for proteinase-activated receptor-2 in arthritis

Design and Synthesis of Novel Aminoindazole-pyrrolo2,3-bpyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

Mitogen‐activated protein kinase phosphatase‐2 deletion modifies ventral tegmental area function and connectivity and alters reward processing

Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts

Protease-Activated Receptor 2: Are Common Functions in Glial and Immune Cells Linked to Inflammation-Related CNS Disorders?

Inhibition of Lipopolysaccharide-Induced Macrophage IL-12 Production by Leishmania mexicana Amastigotes: The Role of Cysteine Peptidases and the NF-κB Signaling Pathway

Determining the prognostic significance of IKKα in prostate cancer

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