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Next-generation direct-acting influenza therapeutics

Translational research : the journal of laboratory and clinical medicine, 2020-06, Vol.220, p.33-42

2020

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Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Nature communications, 2021-11, Vol.12 (1), p.6415-6415, Article 6415

2021

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Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics

PLoS pathogens, 2019-08, Vol.15 (8), p.e1007995-e1007995

2019

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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)

2018

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Structure and organization of paramyxovirus particles

Current opinion in virology, 2017-06, Vol.24, p.105-114

2017

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4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

PLoS pathogens, 2023-04, Vol.19 (4), p.e1011342-e1011342

2023

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The paramyxovirus polymerase complex as a target for next-generation anti-paramyxovirus therapeutics

Frontiers in microbiology, 2015-05, Vol.6, p.459-459

2015

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A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

PLoS computational biology, 2020-12, Vol.16 (12), p.e1008451-e1008451

2020

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Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity

PLoS pathogens, 2021-02, Vol.17 (2), p.e1009371-e1009371

2021

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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Nature communications, 2022-07, Vol.13 (1), p.4416-4416, Article 4416

2022

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Structural Insight into Paramyxovirus and Pneumovirus Entry Inhibition

Viruses, 2020-03, Vol.12 (3), p.342

2020

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Envelope protein dynamics in paramyxovirus entry

mBio, 2013-07, Vol.4 (4)

2013

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Biology must develop herd immunity against bad-actor molecules

PLoS pathogens, 2018-06, Vol.14 (6), p.e1007038-e1007038

2018

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Promotion of virus assembly and organization by the measles virus matrix protein

Nature communications, 2018-04, Vol.9 (1), p.1736-10, Article 1736

2018

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Structural and mechanistic studies of measles virus illuminate paramyxovirus entry

PLoS pathogens, 2011-06, Vol.7 (6), p.e1002058-e1002058

2011

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Triggering the measles virus membrane fusion machinery

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.E3018-E3027

2012

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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Nature communications, 2023-08, Vol.14 (1), p.4731-14, Article 4731

2023

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The Respiratory Syncytial Virus Fusion Protein and Neutrophils Mediate the Airway Mucin Response to Pathogenic Respiratory Syncytial Virus Infection

Journal of Virology, 2013-09, Vol.87 (18), p.10070-10082

2013

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Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process

PLoS pathogens, 2015-05, Vol.11 (5), p.e1004880

2015

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A Stabilized Headless Measles Virus Attachment Protein Stalk Efficiently Triggers Membrane Fusion

Journal of Virology, 2013-11, Vol.87 (21), p.11693-11703

2013

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Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses

Current opinion in virology, 2019-04, Vol.35, p.1-13

2019

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Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex

Viruses, 2016-09, Vol.8 (9), p.251

2016

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Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo

PLoS pathogens, 2024-02, Vol.20 (2), p.e1011993-e1011993

2024

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Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

Nature communications, 2024-02, Vol.15 (1), p.1189-1189, Article 1189

2024

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The Measles Virus Nucleocapsid Protein Tail Domain Is Dispensable for Viral Polymerase Recruitment and Activity

The Journal of biological chemistry, 2013-10, Vol.288 (41), p.29943-29953

2013

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Next-generation direct-acting influenza therapeutics

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

Structure and organization of paramyxovirus particles

4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

The paramyxovirus polymerase complex as a target for next-generation anti-paramyxovirus therapeutics

A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

Structural Insight into Paramyxovirus and Pneumovirus Entry Inhibition

Envelope protein dynamics in paramyxovirus entry

Biology must develop herd immunity against bad-actor molecules

Promotion of virus assembly and organization by the measles virus matrix protein

Structural and mechanistic studies of measles virus illuminate paramyxovirus entry

Triggering the measles virus membrane fusion machinery

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

The Respiratory Syncytial Virus Fusion Protein and Neutrophils Mediate the Airway Mucin Response to Pathogenic Respiratory Syncytial Virus Infection

Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process

A Stabilized Headless Measles Virus Attachment Protein Stalk Efficiently Triggers Membrane Fusion

Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex

Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

The Measles Virus Nucleocapsid Protein Tail Domain Is Dispensable for Viral Polymerase Recruitment and Activity

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