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A Tandem Heck-Carbocyclization/Suzuki-Coupling Approach to the Stereoselective Syntheses of Asymmetric 3,3-(Diarylmethylene)indolinones

Journal of organic chemistry, 2005-04, Vol.70 (9), p.3741-3744

2005

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Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.233-247

2011

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Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury

Toxicological sciences, 2018-06, Vol.163 (2), p.374-384

2018

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Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

Expert opinion on investigational drugs, 2008-12, Vol.17 (12), p.1865-1882

2008

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Colony-stimulating factor-1 receptor inhibitors for the treatment of cancer and inflammatory disease

Current topics in medicinal chemistry, 2009-05, Vol.9 (7), p.599-610

2009

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Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors

The Journal of biological chemistry, 2007-02, Vol.282 (6), p.4094-4101

2007

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GPR40-Mediated G α 12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets

Molecular pharmacology, 2018-06, Vol.93 (6), p.581-591

2018

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Design and synthesis of a pyrido[2,3- d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2355-2361

2008

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Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition

American journal of physiology. Regulatory, integrative and comparative physiology, 2013-11, Vol.305 (9), p.R1040-R1050

2013

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Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents

European journal of medicinal chemistry, 2017-09, Vol.138, p.830-853

2017

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Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

Journal of medicinal chemistry, 2011-02, Vol.54 (3), p.788-808

2011

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Developments in factor Xa inhibitors for the treatment of thromboembolic disorders

Medicinal research reviews, 2011-03, Vol.31 (2), p.202-283

2011

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Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1857-1861

2005

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Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]‑1H‑benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3859-3874

2015

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Discovery of a novel potent GPR40 full agonist

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.720-726

2018

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Transient Receptor Potential Melastatin 8 Channel Inhibition Potentiates the Hypothermic Response to Transient Receptor Potential Vanilloid 1 Activation in the Conscious Mouse

Critical care medicine, 2014-05, Vol.42 (5), p.e355-e363

2014

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Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α‑Fluorination

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.16-21

2019

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Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (17), p.4216-4222

2016

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Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.1903-1907

2012

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Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141)

Journal of medicinal chemistry, 2011-11, Vol.54 (22), p.7860-7883

2011

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Protein kinase inhibitors for the treatment of inflammatory disease

Current topics in medicinal chemistry, 2009-05, Vol.9 (7), p.598

Player, Mark R

2009

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Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating

Tetrahedron letters, 2003, Vol.44 (1), p.175-178

2003

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Protein kinase inhibitors for the treatment of inflammatory disease

Current topics in medicinal chemistry, 2009-05, Vol.9 (8), p.677

Player, Mark R

2009

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Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1843-1856

2010

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Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors

Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.1081-1099

2009

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A Tandem Heck-Carbocyclization/Suzuki-Coupling Approach to the Stereoselective Syntheses of Asymmetric 3,3-(Diarylmethylene)indolinones

Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

Colony-stimulating factor-1 receptor inhibitors for the treatment of cancer and inflammatory disease

Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors

GPR40-Mediated G α 12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets

Design and synthesis of a pyrido[2,3- d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors

Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition

Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

Developments in factor Xa inhibitors for the treatment of thromboembolic disorders

Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists

Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]‑1H‑benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Discovery of a novel potent GPR40 full agonist

Transient Receptor Potential Melastatin 8 Channel Inhibition Potentiates the Hypothermic Response to Transient Receptor Potential Vanilloid 1 Activation in the Conscious Mouse

Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α‑Fluorination

Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141)

Protein kinase inhibitors for the treatment of inflammatory disease

Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating

Protein kinase inhibitors for the treatment of inflammatory disease

Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif

Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors

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