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Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy

Trends in cell biology, 2017-10, Vol.27 (10), p.722-737

2017

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Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

Molecular cell, 2012-05, Vol.46 (4), p.449-460

2012

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Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Nature communications, 2019-01, Vol.10 (1), p.187-16, Article 187

2019

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Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior

Trends in biochemical sciences (Amsterdam. Regular ed.), 2013-11, Vol.38 (11), p.566-575

2013

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The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo

PLoS genetics, 2023-03, Vol.19 (3), p.e1010682-e1010682

2023

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Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

Arthritis & rheumatology (Hoboken, N.J.), 2017-07, Vol.69 (7), p.1418-1428

2017

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Benchmarking AlphaMissense pathogenicity predictions against cystic fibrosis variants

PloS one, 2024-01, Vol.19 (1), p.e0297560-e0297560

2024

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Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism

Analytical chemistry (Washington), 2013-07, Vol.85 (14), p.6876-6884

2013

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Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics

Molecular systems biology, 2024-09, Vol.20 (9), p.1049-1075

2024

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Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

eLife, 2018-08, Vol.7

2018

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Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry

Scientific reports, 2022-04, Vol.12 (1), p.6903-6903, Article 6903

2022

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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

eLife, 2016-07, Vol.5

2016

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Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (36), p.13046-13051

2014

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Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (48), p.E4648-E4657

2013

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Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

eLife, 2019-05, Vol.8

2019

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The endoplasmic reticulum HSP40 co‐chaperone ERdj3/DNAJB11 assembles and functions as a tetramer

The EMBO journal, 2017-08, Vol.36 (15), p.2296-2309

2017

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Structural Comparative Modeling of Multi-Domain F508del CFTR

Biomolecules (Basel, Switzerland), 2022-03, Vol.12 (3), p.471

2022

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Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

International journal of molecular sciences, 2020-08, Vol.21 (16), p.5743

2020

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Cystic Fibrosis Modulator Therapies: Bridging Insights from CF to other Membrane Protein Misfolding Diseases

Israel journal of chemistry, 2024-01

2024

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Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS

Acta neuropathologica communications, 2021-02, Vol.9 (1), p.21-21, Article 21

2021

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Modulating protein quality control

eLife, 2016-07, Vol.5

2016

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CFTR Folding: From Structure and Proteostasis to Cystic Fibrosis Personalized Medicine

ACS chemical biology, 2023-10, Vol.18 (10), p.2128-2143

2023

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Benchmarking AlphaFold2 on peptide structure prediction

Structure (London), 2023-01, Vol.31 (1), p.111-119.e2

2023

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Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis

Molecular & cellular proteomics, 2021-01, Vol.20, p.100008-100008, Article 100008

2021

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Use of a semisynthetic epitope to probe histidine kinase activity and regulation

Analytical biochemistry, 2010-02, Vol.397 (2), p.139-143

2010

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Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy

Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior

The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

Benchmarking AlphaMissense pathogenicity predictions against cystic fibrosis variants

Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism

Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

The endoplasmic reticulum HSP40 co‐chaperone ERdj3/DNAJB11 assembles and functions as a tetramer

Structural Comparative Modeling of Multi-Domain F508del CFTR

Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

Cystic Fibrosis Modulator Therapies: Bridging Insights from CF to other Membrane Protein Misfolding Diseases

Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS

Modulating protein quality control

CFTR Folding: From Structure and Proteostasis to Cystic Fibrosis Personalized Medicine

Benchmarking AlphaFold2 on peptide structure prediction

Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis

Use of a semisynthetic epitope to probe histidine kinase activity and regulation

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