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Sobetirome prodrug esters with enhanced blood-brain barrier permeability

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (22), p.5842-5854

2016

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4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

EMBO molecular medicine, 2019-12, Vol.11 (12), p.e10489-n/a

2019

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New synthetic routes to thyroid hormone analogs: d6-sobetirome, 3H-sobetirome, and the antagonist NH-3

Tetrahedron, 2015-09, Vol.71 (35), p.5946-5951

2015

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Increasing Thyromimetic Potency through Halogen Substitution

ChemMedChem, 2016-11, Vol.11 (21), p.2459-2465

2016

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Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration

Bioorganic & medicinal chemistry, 2017-05, Vol.25 (10), p.2743-2753

2017

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Elevated serum tetrac in Graves’ disease: potential pathogenic role in thyroid-associated ophthalmopathy

The journal of clinical endocrinology and metabolism, 2017-03, Vol.102 (3), p.776-785

2017

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Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration

The FASEB journal, 2017-08, Vol.31 (8), p.3425-3438

2017

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New Synthetic Methodology for the Construction of 7-Substituted Farnesyl Diphosphate Analogs

Organic letters, 2011-07, Vol.13 (14), p.3576-3579

2011

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Detection of nonsterol isoprenoids by HPLC–MS/MS

Analytical biochemistry, 2008-12, Vol.383 (1), p.18-24

2008

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Synthesis of Frame-Shifted Farnesyl Diphosphate Analogs

Organic letters, 2012-08, Vol.14 (16), p.4038-4041

2012

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Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide)

Journal of pharmaceutical and biomedical analysis, 2010-11, Vol.53 (3), p.567-575

2010

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Enabling structure-based drug discovery utilizing predicted models

Cell, 2024-02, Vol.187 (3), p.521-525

2024

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New synthetic routes to thyroid hormone analogs: d 6 -sobetirome, 3 H-sobetirome, and the antagonist NH-3

Tetrahedron, 2015-09, Vol.71 (35), p.5946

2015

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Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway

Journal of virology, 2018-03, Vol.92 (6)

2018

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Identification of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies

Blood, 2020-11, Vol.136 (Supplement 1), p.30-30

2020

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Characterization of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies

Blood, 2021-11, Vol.138 (Supplement 1), p.1187-1187

2021

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Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions

Tetrahedron letters, 2005-12, Vol.46 (52), p.9029-9034

2005

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Abstract 2570: Discovery of potent, selective, and orally available WEE1 inhibitors that demonstrate increased DNA damage and mitosis in tumor cells leading to tumor regression in vivo

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2570-2570

2022

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Detection of non-sterol isoprenoids by HPLC-MS/MS

Analytical biochemistry, 2008-08, Vol.383 (1), p.18-24

2008

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Chemical Probes of Protein Prenylation

Protein Prenylation, Part B, 2011, Vol.30, p.91-127

2011

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Synthesis and biological evaluation of centrally modified farnesyl pyrophosphate analogs

Placzek, Andrew T

2009

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Scandium Triflate as an Efficient and Useful Catalyst for the Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Amines under Solvent-Free Conditions

ChemInform, 2006-03, Vol.37 (13), p.no-no

2006

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Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4388-4404

2007

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A prognostic model to guide decision-making on timing of delivery in late preterm pre-eclampsia: the PEACOCK prospective cohort study

Health technology assessment (Winchester, England), 2021-05, Vol.25 (30), p.1-32

2021

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Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial

The Lancet (British edition), 2019-09, Vol.394 (10204), p.1181-1190

2019

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Sobetirome prodrug esters with enhanced blood-brain barrier permeability

4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

New synthetic routes to thyroid hormone analogs: d6-sobetirome, 3H-sobetirome, and the antagonist NH-3

Increasing Thyromimetic Potency through Halogen Substitution

Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration

Elevated serum tetrac in Graves’ disease: potential pathogenic role in thyroid-associated ophthalmopathy

Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration

New Synthetic Methodology for the Construction of 7-Substituted Farnesyl Diphosphate Analogs

Detection of nonsterol isoprenoids by HPLC–MS/MS

Synthesis of Frame-Shifted Farnesyl Diphosphate Analogs

Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide)

Enabling structure-based drug discovery utilizing predicted models

New synthetic routes to thyroid hormone analogs: d 6 -sobetirome, 3 H-sobetirome, and the antagonist NH-3

Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway

Identification of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies

Characterization of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies

Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions

Abstract 2570: Discovery of potent, selective, and orally available WEE1 inhibitors that demonstrate increased DNA damage and mitosis in tumor cells leading to tumor regression in vivo

Detection of non-sterol isoprenoids by HPLC-MS/MS

Chemical Probes of Protein Prenylation

Synthesis and biological evaluation of centrally modified farnesyl pyrophosphate analogs

Scandium Triflate as an Efficient and Useful Catalyst for the Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Amines under Solvent-Free Conditions

Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors

A prognostic model to guide decision-making on timing of delivery in late preterm pre-eclampsia: the PEACOCK prospective cohort study

Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial

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