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Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.7926-7962

2021

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Structure–Activity Relationships and Therapeutic Potentials of 5‑HT7 Receptor Ligands: An Update

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8475-8503

2018

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Natural products in drug discovery: advances and opportunities

Nature reviews. Drug discovery, 2021-03, Vol.20 (3), p.200-216

2021

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Synthesis and in Vitro Evaluation of CAPE Derivatives as Ferroptosis Inducers in Triple Negative Breast Cancer

ACS medicinal chemistry letters, 2024-05, Vol.15 (5), p.706-713

2024

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Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes

Current medicinal chemistry, 2018, Vol.25 (37), p.4827

2018

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(+)-Methyl (1R,2S)‑2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.372-384

2018

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Novel Sigma Receptor Ligand–Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9531-9544

2017

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Discovery of Novel Acetamide-Based Heme Oxygenase‑1 Inhibitors with Potent In Vitro Antiproliferative Activity

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13373-13393

2021

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Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia

Molecules (Basel, Switzerland), 2022-05, Vol.27 (10), p.3220

2022

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Synthesis of New Arylpiperazinylalkylthiobenzimidazole, Benzothiazole, or Benzoxazole Derivatives as Potent and Selective 5-HT1A Serotonin Receptor Ligands

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4529-4538

2008

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Non-competitive heme oxygenase-1 activity inhibitor reduces non-small cell lung cancer glutathione content and regulates cell proliferation

Molecular biology reports, 2020-03, Vol.47 (3), p.1949-1964

2020

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Curcumin, the golden spice in treating cardiovascular diseases

Biotechnology advances, 2020-01, Vol.38, p.107343-107343, Article 107343

2020

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Development of New Benzylpiperazine Derivatives as σ1 Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects

ACS chemical neuroscience, 2021-06, Vol.12 (11), p.2003-2012

2021

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Targeting STATs in neuroinflammation: The road less traveled

Pharmacological research, 2019-03, Vol.141, p.73-84

2019

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Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib

Molecular neurobiology, 2019-02, Vol.56 (2), p.1451-1460

2019

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Heme Oxygenase-1 Overexpression Promotes Uveal Melanoma Progression and Is Associated with Poor Clinical Outcomes

Antioxidants, 2022-10, Vol.11 (10), p.1997

2022

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Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills

Antioxidants & redox signaling, 2024-01, Vol.40 (1-3), p.40

2024

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Glucose-Impaired Corneal Re-Epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate

Antioxidants, 2021-05, Vol.10 (6), p.831

2021

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Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1853

2022

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Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs

ChemMedChem, 2021-12, Vol.16 (23), p.3496-3512

2021

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Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells

International journal of molecular sciences, 2022-05, Vol.23 (10), p.5709

2022

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Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents

European journal of medicinal chemistry, 2017-12, Vol.142, p.459-485

2017

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Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats

International journal of molecular sciences, 2019-05, Vol.20 (10), p.2441

2019

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Nrf2 as regulator of innate immunity: A molecular Swiss army knife

Biotechnology advances, 2018-03, Vol.36 (2), p.358-370

2018

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Evaluation of the anticancer effects exerted by 5-fluorouracil and heme oxygenase-1 inhibitor hybrids in HTC116 colorectal cancer cells

Journal of enzyme inhibition and medicinal chemistry, 2024-12, Vol.39 (1), p.2337191-2337191

2024

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Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

Structure–Activity Relationships and Therapeutic Potentials of 5‑HT7 Receptor Ligands: An Update

Natural products in drug discovery: advances and opportunities

Synthesis and in Vitro Evaluation of CAPE Derivatives as Ferroptosis Inducers in Triple Negative Breast Cancer

Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes

(+)-Methyl (1R,2S)‑2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

Novel Sigma Receptor Ligand–Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect

Discovery of Novel Acetamide-Based Heme Oxygenase‑1 Inhibitors with Potent In Vitro Antiproliferative Activity

Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia

Synthesis of New Arylpiperazinylalkylthiobenzimidazole, Benzothiazole, or Benzoxazole Derivatives as Potent and Selective 5-HT1A Serotonin Receptor Ligands

Non-competitive heme oxygenase-1 activity inhibitor reduces non-small cell lung cancer glutathione content and regulates cell proliferation

Curcumin, the golden spice in treating cardiovascular diseases

Development of New Benzylpiperazine Derivatives as σ1 Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects

Targeting STATs in neuroinflammation: The road less traveled

Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib

Heme Oxygenase-1 Overexpression Promotes Uveal Melanoma Progression and Is Associated with Poor Clinical Outcomes

Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills

Glucose-Impaired Corneal Re-Epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate

Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer

Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells

Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents

Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats

Nrf2 as regulator of innate immunity: A molecular Swiss army knife

Evaluation of the anticancer effects exerted by 5-fluorouracil and heme oxygenase-1 inhibitor hybrids in HTC116 colorectal cancer cells

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