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Histone Deacetylase Inhibition Sensitizes PD1 Blockade-Resistant B-cell Lymphomas

Cancer immunology research, 2019-08, Vol.7 (8), p.1318-1331

2019

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Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy

Frontiers in immunology, 2023-09, Vol.14, p.1260545

2023

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Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

Molecular cancer therapeutics, 2022-03, Vol.21 (3), p.397-406

2022

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The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Molecular cancer therapeutics, 2024-04, Vol.23 (4), p.464

2024

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Preparation of Pyrrolidine-Based PDE4 Inhibitors via Enantioselective Conjugate Addition of α-Substituted Malonates to Aromatic Nitroalkenes

Organic letters, 2006-03, Vol.8 (7), p.1495-1498

2006

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Recent applications of olefin metathesis to combinatorial chemistry

Current opinion in chemical biology, 2004-06, Vol.8 (3), p.245-254

2004

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Ring closing metathesis in organic synthesis: Evolution of a high speed, solid phase method for the preparation of β-turn mimetics

Tetrahedron, 1999-07, Vol.55 (27), p.8189-8198

1999

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Solid phase heterocyclic synthesis via ring closing metathesis: Traceless linking and cyclative cleavage through a carbon-carbon double bond

Tetrahedron letters, 1997-10, Vol.38 (41), p.7143-7146

1997

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Stereoselective Synthesis of Functionalized Carbocycles and Heterocycles via an Ester Enolate Claisen/Ring-Closing Metathesis Manifold

Journal of organic chemistry, 1998-05, Vol.63 (10), p.3158-3159

1998

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A second generation solid phase approach to Freidinger lactams: Application of Fukuyama's amine synthesis and cyclative release via ring closing metathesis

Tetrahedron letters, 1998-04, Vol.39 (18), p.2667-2670

1998

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Synthesis of ethisolide, isoavenaciolide, and avenaciolide

Journal of organic chemistry, 1992-04, Vol.57 (8), p.2228-2235

1992

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Abstract B007: OKI-179 is a novel, oral, class I specific histone deacetylase inhibitor in phase 1 clinical trials

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.B007-B007

2019

Volltextzugriff (PDF)

Phase 1 study of OKI-179, an oral class 1-selective depsipeptide HDAC inhibitor, in patients with advanced solid tumors: Final results

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.3075-3075

2021

Volltextzugriff (PDF)

Total Synthesis of Rapamycin

Chemistry : a European journal, 1995-08, Vol.1 (5), p.318-333

1995

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HDAC and PD-1 inhibition in humanized triple-negative breast cancer xenografts

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e14604-e14604

2017

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trans-3-benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1781-1786

1998

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Total synthesis of (±)-isoavenaciolide and (±)-avenaciolide

Tetrahedron letters, 1986, Vol.27 (29), p.3345-3348

1986

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Total synthesis of ionophore antibiotic X-14547A (indanomycin)

Journal of organic chemistry, 1994-01, Vol.59 (2), p.332-347

1994

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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1781

1998

Volltextzugriff (PDF)

trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B 4 (LTB 4) receptor

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1781-1786

1998

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Recent Applications of Olefin Metathesis to Combinatorial Chemistry

ChemInform, 2005-02, Vol.36 (5), p.no-no

2005

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Total synthesis of ionophore antibiotic X-14547 A (indanomycin)

Journal of organic chemistry, 1994-01, Vol.59 (2), p.332-347

1994

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Diastereoselectivity enhancement in vinylcuprate addition to β-alkoxyaldehydes via a vinylsilane

Tetrahedron letters, 1991-02, Vol.32 (7), p.857-858

1991

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Total synthesis of (±)-pulo'upone

Tetrahedron letters, 1988, Vol.29 (23), p.2757-2760

1988

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Histone Deacetylase Inhibition Sensitizes PD1 Blockade-Resistant B-cell Lymphomas

Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy

First-in-Human Dose-Escalation Study of the Novel Oral Depsipeptide Class I-Targeting HDAC Inhibitor Bocodepsin (OKI-179) in Patients with Advanced Solid Tumors

Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors

The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Preparation of Pyrrolidine-Based PDE4 Inhibitors via Enantioselective Conjugate Addition of α-Substituted Malonates to Aromatic Nitroalkenes

Recent applications of olefin metathesis to combinatorial chemistry

Ring closing metathesis in organic synthesis: Evolution of a high speed, solid phase method for the preparation of β-turn mimetics

Solid phase heterocyclic synthesis via ring closing metathesis: Traceless linking and cyclative cleavage through a carbon-carbon double bond

Stereoselective Synthesis of Functionalized Carbocycles and Heterocycles via an Ester Enolate Claisen/Ring-Closing Metathesis Manifold

A second generation solid phase approach to Freidinger lactams: Application of Fukuyama's amine synthesis and cyclative release via ring closing metathesis

Synthesis of ethisolide, isoavenaciolide, and avenaciolide

Abstract B007: OKI-179 is a novel, oral, class I specific histone deacetylase inhibitor in phase 1 clinical trials

Phase 1 study of OKI-179, an oral class 1-selective depsipeptide HDAC inhibitor, in patients with advanced solid tumors: Final results

Total Synthesis of Rapamycin

HDAC and PD-1 inhibition in humanized triple-negative breast cancer xenografts

trans-3-benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor

Total synthesis of (±)-isoavenaciolide and (±)-avenaciolide

Total synthesis of ionophore antibiotic X-14547A (indanomycin)

trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor

trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B 4 (LTB 4) receptor

Recent Applications of Olefin Metathesis to Combinatorial Chemistry

Total synthesis of ionophore antibiotic X-14547 A (indanomycin)

Diastereoselectivity enhancement in vinylcuprate addition to β-alkoxyaldehydes via a vinylsilane

Total synthesis of (±)-pulo'upone

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