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Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

Journal of medicinal chemistry, 1999-01, Vol.42 (2), p.260-266

1999

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The heat shock and ethanol stress responses of yeast exhibit extensive similarity and functional overlap

FEMS Microbiology Letters, 1995-12, Vol.134 (2), p.121-127

Piper, Peter W.

1995

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Molecular events associated with acquisition of heat tolerance by the yeast Saccharomyces cerevisiae

FEMS microbiology reviews, 1993-08, Vol.11 (4), p.339-355

Piper, P.W

1993

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The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in Saccharomyces cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives

Molecular microbiology, 2001-11, Vol.42 (4), p.919-930

2001

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Induction of major heat-shock proteins of Saccharomyces cerevisiae, including plasma membrane Hsp30, by ethanol levels above a critical threshold

Microbiology (Society for General Microbiology), 1994-11, Vol.140 ( Pt 11) (11), p.3031-3038

1994

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Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

Cell, 1997-07, Vol.90 (1), p.65-75

1997

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ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

The EMBO journal, 1998-08, Vol.17 (16), p.4829-4836

1998

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The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

The EMBO journal, 2000-08, Vol.19 (16), p.4383-4392

2000

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Stress induction of HSP30, the plasma membrane heat shock protein gene of Saccharomyces cerevisiae, appears not to use known stress-regulated transcription factors

Microbiology (Society for General Microbiology), 1999-01, Vol.145 ( Pt 1) (1), p.231-239

1999

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Yeast superoxide dismutase mutants reveal a pro-oxidant action of weak organic acid food preservatives

Free radical biology & medicine, 1999-12, Vol.27 (11), p.1219-1227

Piper, Peter W

1999

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Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

The EMBO journal, 1999-02, Vol.18 (3), p.754-762

1999

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The C-terminus of yeast plasma membrane H +-ATPase is essential for the regulation of this enzyme by heat shock protein Hsp30, but not for stress activation

FEBS letters, 1997-11, Vol.418 (1), p.123-126

1997

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The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections

Microbiology (Society for General Microbiology), 1999-12, Vol.145 ( Pt 12) (12), p.3455-3463

1999

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Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms

Yeast (Chichester, England), 2001-04, Vol.18 (6), p.499-509

2001

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Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism

Journal of Bacteriology, 1999-08, Vol.181 (15), p.4644-4652

1999

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Mnsod overexpression extends the yeast chronological (G 0) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells

Free radical biology & medicine, 2003-06, Vol.34 (12), p.1599-1606

2003

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Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae

Biochemical journal, 2006-04, Vol.395 (1), p.73-80

2006

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Hsp90 chaperone control over transcriptional regulation by the yeast Slt2(Mpk1)p and human ERK5 mitogen-activated protein kinases (MAPKs)

Biochemical Society transactions, 2006-11, Vol.34 (Pt 5), p.783-785

2006

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Weak organic acid treatment causes a trehalose accumulation in low-pH cultures of Saccharomyces cerevisiae, not displayed by the more preservative-resistant Zygosaccharomyces bailii

FEMS microbiology letters, 1999, Vol.170 (1), p.89-95

1999

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Weak acid preservatives block the heat shock response and heat-shock-element-directed lacZ expression of low pH Saccharomyces cerevisiae cultures, an inhibitory action partially relieved by respiratory deficiency

Microbiology (Society for General Microbiology), 1994-05, Vol.140 ( Pt 5) (5), p.1085-1096

1994

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Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae)

Molecular & general genetics, 1994-05, Vol.243 (3), p.358-362

1994

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Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP‐binding cassette transporter

Yeast (Chichester, England), 2003-05, Vol.20 (7), p.575-585

2003

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Hypoxia abolishes transience of the heat-shock response in the methylotrophic yeast Hansenula polymorpha

Microbiology (Society for General Microbiology), 2005-03, Vol.151 (Pt 3), p.805-811

2005

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The Hsp90 chaperone as a promising drug target

Current opinion in investigational drugs (London, England : 2000), 2001-11, Vol.2 (11), p.1606

Piper, P W

2001

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Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach

Cell stress & chaperones, 2004-12, Vol.9 (4), p.359-368

2004

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Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

The heat shock and ethanol stress responses of yeast exhibit extensive similarity and functional overlap

Molecular events associated with acquisition of heat tolerance by the yeast Saccharomyces cerevisiae

The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in Saccharomyces cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives

Induction of major heat-shock proteins of Saccharomyces cerevisiae, including plasma membrane Hsp30, by ethanol levels above a critical threshold

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

Stress induction of HSP30, the plasma membrane heat shock protein gene of Saccharomyces cerevisiae, appears not to use known stress-regulated transcription factors

Yeast superoxide dismutase mutants reveal a pro-oxidant action of weak organic acid food preservatives

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

The C-terminus of yeast plasma membrane H +-ATPase is essential for the regulation of this enzyme by heat shock protein Hsp30, but not for stress activation

The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections

Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms

Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism

Mnsod overexpression extends the yeast chronological (G 0) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells

Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae

Hsp90 chaperone control over transcriptional regulation by the yeast Slt2(Mpk1)p and human ERK5 mitogen-activated protein kinases (MAPKs)

Weak organic acid treatment causes a trehalose accumulation in low-pH cultures of Saccharomyces cerevisiae, not displayed by the more preservative-resistant Zygosaccharomyces bailii

Weak acid preservatives block the heat shock response and heat-shock-element-directed lacZ expression of low pH Saccharomyces cerevisiae cultures, an inhibitory action partially relieved by respiratory deficiency

Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae)

Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP‐binding cassette transporter

Hypoxia abolishes transience of the heat-shock response in the methylotrophic yeast Hansenula polymorpha

The Hsp90 chaperone as a promising drug target

Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach

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