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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Nature communications, 2016-11, Vol.7 (1), p.13457-13457, Article 13457

2016

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Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

Biochemical journal, 2015-05, Vol.468 (1), p.125-132

2015

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AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

Journal of lipid research, 2012-12, Vol.53 (12), p.2490-2514

2012

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AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism[S]

Journal of lipid research, 2013-01, Vol.54 (1), p.134-151

2013

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Lipogenesis inhibitors: therapeutic opportunities and challenges

Nature reviews. Drug discovery, 2022-04, Vol.21 (4), p.283-305

2022

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ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

Journal of lipid research, 2013-08, Vol.54 (8), p.2095-2108

2013

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Conquering cholesterol: a report from the front lines

Cardiovascular research, 2023-12, Vol.119 (17), p.e160-e163

2023

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Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice

Frontiers in molecular biosciences, 2022-11, Vol.9, p.1001941-1001941

2022

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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

Cell metabolism, 2022-06, Vol.34 (6), p.919-936.e8

2022

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Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders

Trends in molecular medicine, 2017-11, Vol.23 (11), p.1047-1063

2017

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Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr -/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

Arteriosclerosis, thrombosis, and vascular biology, 2017-04, Vol.37 (4), p.647

2017

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LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

Current opinion in lipidology, 2014-08, Vol.25 (4), p.309-315

2014

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The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Proceedings of the National Academy of Sciences - PNAS, 2022-11, Vol.119 (48), p.e2119824119

2022

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Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

Nature metabolism, 2020-09, Vol.2 (9), p.873

2020

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Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice

Cell reports. Medicine, 2023-09, Vol.4 (9), p.101193-101193, Article 101193

2023

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Atherosclerosis in Octodon degus (degu) as a model for human disease

Atherosclerosis, 2010-09, Vol.212 (1), p.48-54

2010

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Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice

Physiological genomics, 2003-09, Vol.15 (1), p.44-51

2003

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Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice

Mechanisms of ageing and development, 2003-07, Vol.124 (7), p.801-810

2003

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Abstract 17608: Identification of a Tissue-specific Very Long-chain Acyl-CoA Synthetase Involved in the Inhibition of ATP-Citrate Lyase (ACL) by ETC-1002: A Novel Mechanism for Cholesterol Biosynthesis Inhibition in the Liver

Circulation (New York, N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A17608-A17608

2015

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Abstract 14653: Prevention of Diet-induced Metabolic Dysregulation, Inflammation and Atherosclerosis in Ldlr-/- Mice by Treatment With the ACL Inhibitor ETC-1002

Circulation (New York, N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A14653-A14653

2015

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AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases: Thematic Review Series: New Lipid and Lipoprotein Targets for the Treatment of Cardiometabolic Diseases

Journal of lipid research, 2012-12, Vol.53 (12), p.2490-2514

2012

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Targeting Liver ATP-Citrate Lyase with Bempedoic Acid: A Complementary LDL-C Lowering Strategy for Treating Hypercholesterolemia

Atherosclerosis. Supplements, 2018-06, Vol.32, p.17-17

2018

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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism[S]

Lipogenesis inhibitors: therapeutic opportunities and challenges

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

Conquering cholesterol: a report from the front lines

Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice

Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders

Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr -/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice

Atherosclerosis in Octodon degus (degu) as a model for human disease

Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice

Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice

Abstract 17608: Identification of a Tissue-specific Very Long-chain Acyl-CoA Synthetase Involved in the Inhibition of ATP-Citrate Lyase (ACL) by ETC-1002: A Novel Mechanism for Cholesterol Biosynthesis Inhibition in the Liver

Abstract 14653: Prevention of Diet-induced Metabolic Dysregulation, Inflammation and Atherosclerosis in Ldlr-/- Mice by Treatment With the ACL Inhibitor ETC-1002

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases: Thematic Review Series: New Lipid and Lipoprotein Targets for the Treatment of Cardiometabolic Diseases

Targeting Liver ATP-Citrate Lyase with Bempedoic Acid: A Complementary LDL-C Lowering Strategy for Treating Hypercholesterolemia

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