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Highly efficient therapeutic gene editing of human hematopoietic stem cells

Nature medicine, 2019-05, Vol.25 (5), p.776-783

2019

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Therapeutic base editing of human hematopoietic stem cells

Nature medicine, 2020-04, Vol.26 (4), p.535-541

2020

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Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM

Nature communications, 2019-04, Vol.10 (1), p.1903-1903, Article 1903

2019

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CRISPResso2 provides accurate and rapid genome editing sequence analysis

Nature biotechnology, 2019-03, Vol.37 (3), p.224-226

2019

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PrimeDesign software for rapid and simplified design of prime editing guide RNAs

Nature communications, 2021-02, Vol.12 (1), p.1034-6, Article 1034

2021

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Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing

The Journal of experimental medicine, 2017-10, Vol.214 (10), p.2875-2887

2017

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Assessment of computational methods for the analysis of single-cell ATAC-seq data

Genome Biology, 2019-11, Vol.20 (1), p.241-241, Article 241

2019

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Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

Nature biotechnology, 2019-03, Vol.37 (3), p.276-282

2019

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CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

Nature biotechnology, 2022-02, Vol.40 (2), p.189-193

2022

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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Nature (London), 2015-11, Vol.527 (7577), p.192-197

2015

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LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

Circulation (New York, N.Y.), 2014-10, Vol.130 (17), p.1452-1465

2014

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Predicting chromatin organization using histone marks

Genome Biology, 2015-08, Vol.16 (1), p.162-162, Article 162

2015

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BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

Molecular cell, 2015-02, Vol.57 (4), p.636-647

2015

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Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms

Cancer cell, 2021-11, Vol.39 (11), p.1531-1547.e10

2021

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GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs

PLoS computational biology, 2021-09, Vol.17 (9), p.e1009444-e1009444

2021

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Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

Cell, 2016-06, Vol.165 (6), p.1389-1400

2016

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CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

Nature chemical biology, 2019-05, Vol.15 (5), p.529

2019

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Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis

Nature genetics, 2019-07, Vol.51 (7), p.1149-1159

2019

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Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models

PLoS computational biology, 2022-10, Vol.18 (10), p.e1009880-e1009880

2022

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CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

Nature chemical biology, 2019-05, Vol.15 (5), p.529-539

2019

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Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions

Molecular cell, 2015-01, Vol.57 (2), p.304-316

2015

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Analysis of chromatin-state plasticity identifies cell-type–specific regulators of H3K27me3 patterns

Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (3), p.E344-E353

2014

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Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments

Nature protocols, 2018-05, Vol.13 (5), p.946-986

2018

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Robust and Scalable Learning of Complex Intrinsic Dataset Geometry via ElPiGraph

Entropy (Basel, Switzerland), 2020-03, Vol.22 (3), p.296

2020

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Multi-scale chromatin state annotation using a hierarchical hidden Markov model

Nature communications, 2017-04, Vol.8 (1), p.15011-15011, Article 15011

2017

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Highly efficient therapeutic gene editing of human hematopoietic stem cells

Therapeutic base editing of human hematopoietic stem cells

Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM

CRISPResso2 provides accurate and rapid genome editing sequence analysis

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing

Assessment of computational methods for the analysis of single-cell ATAC-seq data

Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

Predicting chromatin organization using histone marks

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms

GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis

Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions

Analysis of chromatin-state plasticity identifies cell-type–specific regulators of H3K27me3 patterns

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments

Robust and Scalable Learning of Complex Intrinsic Dataset Geometry via ElPiGraph

Multi-scale chromatin state annotation using a hierarchical hidden Markov model

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