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Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry

Beilstein journal of organic chemistry, 2018-08, Vol.14 (1), p.2035-2064

2018

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Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6501-6517

2018

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Glycine Transporter Type I (GlyT1) Inhibitor, Bitopertin: A Journey from Lab to Patient

Chimia, 2018-08, Vol.72 (7), p.477

2018

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Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia

Neuropharmacology, 2012-02, Vol.62 (2), p.1152-1161

2012

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Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antagonists

Molecular pharmacology, 2009-09, Vol.76 (3), p.618-631

2009

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BACE1 inhibitors: A head group scan on a series of amides

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4239-4243

2013

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The Voltage-dependent Anion Channel Is the Target for a New Class of Inhibitors of the Mitochondrial Permeability Transition Pore

The Journal of biological chemistry, 2003-12, Vol.278 (50), p.49812-49818

2003

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Structural insights into the inhibition of glycine reuptake

Nature (London), 2021-03, Vol.591 (7851), p.677-681

2021

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A Real-World Perspective on Molecular Design

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6086-6100

2016

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β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3980-3995

2013

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Discovery of Orally Available and Brain Penetrant AEP Inhibitors

Journal of medicinal chemistry, 2023-12, Vol.66 (24), p.17026-17043

2023

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Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4444-4457

2017

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Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1511-1525

2020

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The Mitochondrial Effects of Small Organic Ligands of BCL-2

The Journal of biological chemistry, 2006-04, Vol.281 (15), p.10066-10072

2006

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Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential

Pharmacology, biochemistry and behavior, 2010-12, Vol.97 (2), p.185-191

2010

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[11C]-RO5013853: a New PET Radioligand for the Glycine Transporter TYPE 1

Neuropsychopharmacology (New York, N.Y.), 2014-08, Vol.39 (9), p.2272-2272

2014

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Erratum: [11C]-RO5013853: a New PET Radioligand for the Glycine Transporter TYPE 1

Neuropsychopharmacology (New York, N.Y.), 2014-07, Vol.39 (9), p.2272-2272

2014

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A Real-World Perspective on Molecular Design: Miniperspective

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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Mitochondrial Effects of Small Organic Ligands of BCL-2: SENSITIZATION OF BCL-2-OVEREXPRESSING CELLS TO APOPTOSIS BY A PYRIMIDINE-2,4,6-TRIONE DERIVATIVE

The Journal of biological chemistry, 2006-04, Vol.281 (15), p.10066-10072

2006

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Total Synthesis of the Lycopodium Alkaloids Magellanine and Magellaninone by Three-fold Annulation of 2-Cyclopentenone

Journal of the American Chemical Society, 1994-06, Vol.116 (11), p.4689-4696

1994

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Inhibiting glycine transporter-1 facilitates cocaine–cue extinction and attenuates reacquisition of cocaine-seeking behavior

Drug and alcohol dependence, 2012-04, Vol.122 (1), p.119-126

2012

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A short and efficient synthesis of the NMDA glycine site antagonist: (3 R,4 R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414)

Tetrahedron letters, 2008-10, Vol.49 (42), p.6079-6080

2008

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3‑Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors

ACS medicinal chemistry letters, 2014-04, Vol.5 (4), p.428-433

2014

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Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry

Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Glycine Transporter Type I (GlyT1) Inhibitor, Bitopertin: A Journey from Lab to Patient

Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia

Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antagonists

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

BACE1 inhibitors: A head group scan on a series of amides

The Voltage-dependent Anion Channel Is the Target for a New Class of Inhibitors of the Mitochondrial Permeability Transition Pore

Structural insights into the inhibition of glycine reuptake

A Real-World Perspective on Molecular Design

Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy

β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Discovery of Orally Available and Brain Penetrant AEP Inhibitors

Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy

Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder

The Mitochondrial Effects of Small Organic Ligands of BCL-2

Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential

[11C]-RO5013853: a New PET Radioligand for the Glycine Transporter TYPE 1

Erratum: [11C]-RO5013853: a New PET Radioligand for the Glycine Transporter TYPE 1

A Real-World Perspective on Molecular Design: Miniperspective

Mitochondrial Effects of Small Organic Ligands of BCL-2: SENSITIZATION OF BCL-2-OVEREXPRESSING CELLS TO APOPTOSIS BY A PYRIMIDINE-2,4,6-TRIONE DERIVATIVE

Total Synthesis of the Lycopodium Alkaloids Magellanine and Magellaninone by Three-fold Annulation of 2-Cyclopentenone

Inhibiting glycine transporter-1 facilitates cocaine–cue extinction and attenuates reacquisition of cocaine-seeking behavior

A short and efficient synthesis of the NMDA glycine site antagonist: (3 R,4 R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414)

3‑Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors

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