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The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus

Scientific reports, 2020-12, Vol.10 (1), p.21314, Article 21314

2020

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Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.369-380

2000

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Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy

Molecular cancer therapeutics, 2023-07, Vol.22 (7), p.807-817

2023

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Practical enantioselective Diels-Alder and aldol reactions using a new chiral controller system

Journal of the American Chemical Society, 1989-07, Vol.111 (14), p.5493-5495

1989

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Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors

Journal of medicinal chemistry, 1999-11, Vol.42 (22), p.4547-4562

1999

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Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3568-3571

1998

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A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe

Cancers, 2020-08, Vol.12 (8), p.2161

2020

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Tetrahedron report number 195 (R)- and (S)-2,3-0-isopropylideneglyceraldehyde in stereoselective organic synthesis

Tetrahedron, 1986, Vol.42 (2), p.447-488

1986

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Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Journal of medicinal chemistry, 1999-12, Vol.42 (26), p.5426-5436

1999

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Synthetic Process Development of BMS-599793 Including Azaindole Negishi Coupling on Kilogram Scale

Organic process research & development, 2013-06, Vol.17 (6), p.907-914

2013

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The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (15), p.1975-1979

2001

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Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes

Journal of molecular biology, 1999-10, Vol.293 (3), p.545-557

1999

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Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines

Journal of medicinal chemistry, 2000-12, Vol.43 (26), p.4948-4963

2000

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The high-pressure reaction of 2,5-dimethylfuran with 2,3- [formula omitted]-isopropylidene- [formula omitted]-glyceraldehyde

Tetrahedron, 1988, Vol.44 (14), p.4569-4573

1988

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Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases

Journal of medicinal chemistry, 2001-08, Vol.44 (16), p.2499-2502

2001

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Synthetic studies on tetrodotoxin (1) stereocontrolled synthesis of the cyclohexane moiety

Tetrahedron letters, 1987, Vol.28 (51), p.6485-6488

1987

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Novel oxidative opening of 2,5-disubstituted furan ring

Tetrahedron letters, 1985, Vol.26 (25), p.3039-3040

1985

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Design and Synthesis of Phosphinamide-Based Hydroxamic Acids as Inhibitors of Matrix Metalloproteinases

Journal of medicinal chemistry, 1999-01, Vol.42 (1), p.87-94

1999

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Heterocycle-based MMP Inhibitors with P2′ Substituents

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.1009-1013

2001

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Total synthesis of (+)-disparlure

Tetrahedron letters, 1987, Vol.28 (23), p.2627-2628

1987

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Stereochemical consequences of nucleophilic additions to 2,3-0-isopropylideneglyceraldehyde. High-pressure approach versus the use of organometallic reagent

Tetrahedron letters, 1985, Vol.26 (34), p.4145-4148

1985

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Application of LC-NMR and LC-MS to the identification of degradation products of a protease inhibitor in dosage formulations

Journal of pharmaceutical and biomedical analysis, 1999-06, Vol.20 (1), p.75-89

1999

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The Next Generation of MMP Inhibitors: Design and Synthesis

Annals of the New York Academy of Sciences, 1999-06, Vol.878 (1), p.40-60

1999

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Asymmetric induction in the high-pressure reaction between 2,3-0-isopropylidene-d-glyceraldehyde and 2,5-dimethylfuran

Tetrahedron letters, 1984, Vol.25 (29), p.3107-3110

1984

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Zirconium tetrachloride as a convenient catalyst for the glycosylation of sterols with 2,3,4,6,6′-penta- O-acetyl-5-hydroxymethylgalactosyl fluoride

Tetrahedron: asymmetry, 1997-04, Vol.8 (8), p.1165-1168

1997

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The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus

Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors

Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy

Practical enantioselective Diels-Alder and aldol reactions using a new chiral controller system

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors

Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors

A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe

Tetrahedron report number 195 (R)- and (S)-2,3-0-isopropylideneglyceraldehyde in stereoselective organic synthesis

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Synthetic Process Development of BMS-599793 Including Azaindole Negishi Coupling on Kilogram Scale

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes

Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines

The high-pressure reaction of 2,5-dimethylfuran with 2,3- [formula omitted]-isopropylidene- [formula omitted]-glyceraldehyde

Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases

Synthetic studies on tetrodotoxin (1) stereocontrolled synthesis of the cyclohexane moiety

Novel oxidative opening of 2,5-disubstituted furan ring

Design and Synthesis of Phosphinamide-Based Hydroxamic Acids as Inhibitors of Matrix Metalloproteinases

Heterocycle-based MMP Inhibitors with P2′ Substituents

Total synthesis of (+)-disparlure

Stereochemical consequences of nucleophilic additions to 2,3-0-isopropylideneglyceraldehyde. High-pressure approach versus the use of organometallic reagent

Application of LC-NMR and LC-MS to the identification of degradation products of a protease inhibitor in dosage formulations

The Next Generation of MMP Inhibitors: Design and Synthesis

Asymmetric induction in the high-pressure reaction between 2,3-0-isopropylidene-d-glyceraldehyde and 2,5-dimethylfuran

Zirconium tetrachloride as a convenient catalyst for the glycosylation of sterols with 2,3,4,6,6′-penta- O-acetyl-5-hydroxymethylgalactosyl fluoride

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