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HDAC8: a multifaceted target for therapeutic interventions

Trends in pharmacological sciences (Regular ed.), 2015-07, Vol.36 (7), p.481-492

2015

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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10000-10016

2018

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Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni

PLoS pathogens, 2013-09, Vol.9 (9), p.e1003645-e1003645

2013

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Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2423-2435

2016

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Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets

PLoS neglected tropical diseases, 2013-09, Vol.7 (9), p.e2428-e2428

2013

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Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis

Pharmaceuticals (Basel, Switzerland), 2022-01, Vol.15 (1), p.80

2022

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Targeting schistosome histone modifying enzymes for drug development

Current pharmaceutical design, 2012, Vol.18 (24), p.3567

2012

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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.566

2018

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Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

PLoS neglected tropical diseases, 2021-11, Vol.15 (11), p.e0009503

2021

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Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

Journal of chemical information and modeling, 2014-10, Vol.54 (10), p.3005-3019

2014

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Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth

International journal for parasitology -- drugs and drug resistance, 2017-04, Vol.7 (1), p.42-50

2017

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Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni

PLoS pathogens, 2010-09, Vol.6 (9), p.e1001115-e1001115

2010

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Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis

PLoS pathogens, 2014-05, Vol.10 (5), p.e1004116

2014

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Corrigendum: Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction

Frontiers in microbiology, 2023-03, Vol.14, p.1190341-1190341

2023

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Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction

Frontiers in microbiology, 2023-02, Vol.14, p.1079855-1079855

2023

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Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism

PLoS neglected tropical diseases, 2018-10, Vol.12 (10), p.e0006873-e0006873

2018

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Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis

ChemMedChem, 2018-08, Vol.13 (15), p.1517-1529

2018

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Analysis of the interactome of Schistosoma mansoni histone deacetylase 8

PLoS neglected tropical diseases, 2017-11, Vol.11 (11), p.e0006089-e0006089

2017

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Isophthalic Acid‐Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni

Archiv der Pharmazie (Weinheim), 2017-08, Vol.350 (8), p.n/a

2017

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Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

Molecular and biochemical parasitology, 2009-11, Vol.168 (1), p.7-15

2009

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Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1436, p.109

2016

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Schistosome genomes: a key step in the war on the worm

M.S. Médecine sciences, 2009-08, Vol.25 (8-9), p.761

2009

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Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata)

PLoS neglected tropical diseases, 2008, Vol.2 (11), p.e330-e330

2008

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Les génomes des schistosomes : une étape clé dans la lutte contre la bilharziose

M.S. Médecine sciences, 2009-08, Vol.25 (8-9), p.761-762

2009

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Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)

Journal of medicinal chemistry, 2019-10, Vol.62 (19), p.8733-8759

2019

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HDAC8: a multifaceted target for therapeutic interventions

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets

Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis

Targeting schistosome histone modifying enzymes for drug development

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth

Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni

Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis

Corrigendum: Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction

Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction

Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis

Analysis of the interactome of Schistosoma mansoni histone deacetylase 8

Isophthalic Acid‐Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni

Schistosome genomes: a key step in the war on the worm

Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata)

Les génomes des schistosomes : une étape clé dans la lutte contre la bilharziose

Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)

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