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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

Oncogene, 2001-03, Vol.20 (13), p.1532-1539

2001

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Role of Endocytosis in the Activation of the Extracellular Signal-Regulated Kinase Cascade by Sequestering and Nonsequestering G Protein-Coupled Receptors

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1489-1494

2000

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Seven-transmembrane receptors

Nature reviews. Molecular cell biology, 2002-09, Vol.3 (9), p.639-650

2002

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Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors

Nature reviews. Neuroscience, 2001-10, Vol.2 (10), p.727-733

2001

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Activation and Targeting of Extracellular Signal-Regulated Kinases by β-Arrestin Scaffolds

Proceedings of the National Academy of Sciences - PNAS, 2001-02, Vol.98 (5), p.2449-2454

2001

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β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

The Journal of biological chemistry, 2002-03, Vol.277 (11), p.9429-9436

2002

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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation

The Journal of biological chemistry, 2003-02, Vol.278 (8), p.6258-6267

2003

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Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity

Molecular pharmacology, 2002-11, Vol.62 (5), p.971-974

2002

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Transactivation of the EGF Receptor Mediates IGF-1-stimulated Shc Phosphorylation and ERK1/2 Activation in COS-7 Cells

The Journal of biological chemistry, 2000-07, Vol.275 (29), p.22583-22589

2000

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PKA-mediated phosphorylation of the β1-adrenergic receptor promotes Gs/Gi switching

Cellular signalling, 2004-12, Vol.16 (12), p.1397-1403

2004

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Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation

The Journal of biological chemistry, 2000-12, Vol.275 (49), p.38131-38134

2000

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Activation of FP Prostanoid Receptor Isoforms Leads to Rho-mediated Changes in Cell Morphology and in the Cell Cytoskeleton

The Journal of biological chemistry, 1999-12, Vol.274 (50), p.35944-35949

1999

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Prostanoid receptor heterogeneity through alternative mRNA splicing

Life sciences (1973), 1998, Vol.62 (17), p.1479-1483

1998

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Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor

The Journal of biological chemistry, 1997-01, Vol.272 (2), p.883-887

1997

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FPT155-001: A phase Ia/Ib study of FPT155 (CD80-FC) in patients with advanced solid tumors

Journal of clinical oncology, 2019-03, Vol.37 (8_suppl), p.TPS42-TPS42

2019

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FPA144-001: A first in human study of FPA 144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody in patients with advanced solid tumors

Journal of clinical oncology, 2016-02, Vol.34 (4_suppl), p.140-140

2016

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The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

The Journal of biological chemistry, 2000-03, Vol.275 (13), p.9572-9580

2000

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Differential regulation of Ca(2+)-dependent Cl- currents by FP prostanoid receptor isoforms in Xenopus oocytes

Biochemical pharmacology, 2002-05, Vol.63 (10), p.1797-1806

2002

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Antitumor activity and safety of FPA144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody, in patients with FGFR2b+ gastric cancer and advanced solid tumors

Journal of clinical oncology, 2016-05, Vol.34 (15_suppl), p.2502-2502

2016

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Abstract B005: FPT155, a novel therapeutic CD80-Fc fusion protein with potent antitumor activity in preclinical models

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.B005-B005

2018

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Abstract 2845: Expression of FGFR2b in gastric cancer as measured by immunohistochemistry with a highly specific monoclonal antibody

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2845-2845

2014

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Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

The Journal of biological chemistry, 2001-06, Vol.276 (25), p.23155-23160

2001

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Differential regulation of Ca2+-dependent Cl- currents by FP prostanoid receptor isoforms in Xenopus oocytes

Biochemical pharmacology, 2002-05, Vol.63 (10), p.1797-1806

2002

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Abstract 5446: FPA144: A therapeutic antibody for treating patients with gastric cancers bearing FGFR2 gene amplification

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5446-5446

2014

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Selective Inhibition of Heterotrimeric GsSignaling

The Journal of biological chemistry, 2002-08, Vol.277 (32), p.28631-28640

2002

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

Role of Endocytosis in the Activation of the Extracellular Signal-Regulated Kinase Cascade by Sequestering and Nonsequestering G Protein-Coupled Receptors

Seven-transmembrane receptors

Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors

Activation and Targeting of Extracellular Signal-Regulated Kinases by β-Arrestin Scaffolds

β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation

Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity

Transactivation of the EGF Receptor Mediates IGF-1-stimulated Shc Phosphorylation and ERK1/2 Activation in COS-7 Cells

PKA-mediated phosphorylation of the β1-adrenergic receptor promotes Gs/Gi switching

Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation

Activation of FP Prostanoid Receptor Isoforms Leads to Rho-mediated Changes in Cell Morphology and in the Cell Cytoskeleton

Prostanoid receptor heterogeneity through alternative mRNA splicing

Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor

FPT155-001: A phase Ia/Ib study of FPT155 (CD80-FC) in patients with advanced solid tumors

FPA144-001: A first in human study of FPA 144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody in patients with advanced solid tumors

The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

Differential regulation of Ca(2+)-dependent Cl- currents by FP prostanoid receptor isoforms in Xenopus oocytes

Antitumor activity and safety of FPA144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody, in patients with FGFR2b+ gastric cancer and advanced solid tumors

Abstract B005: FPT155, a novel therapeutic CD80-Fc fusion protein with potent antitumor activity in preclinical models

Abstract 2845: Expression of FGFR2b in gastric cancer as measured by immunohistochemistry with a highly specific monoclonal antibody

Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

Differential regulation of Ca2+-dependent Cl- currents by FP prostanoid receptor isoforms in Xenopus oocytes

Abstract 5446: FPA144: A therapeutic antibody for treating patients with gastric cancers bearing FGFR2 gene amplification

Selective Inhibition of Heterotrimeric GsSignaling

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